2000
Attenuated Nitric Oxide Synthase Activity and Protein Expression Accompany Intestinal Ischemia/Reperfusion Injury in Rats
Khanna A, Rossman J, Fung H, Caty M. Attenuated Nitric Oxide Synthase Activity and Protein Expression Accompany Intestinal Ischemia/Reperfusion Injury in Rats. Biochemical And Biophysical Research Communications 2000, 269: 160-164. PMID: 10694494, DOI: 10.1006/bbrc.2000.2266.Peer-Reviewed Original ResearchConceptsNitric oxide synthase activityOxide synthase activityNOS activityReactive oxygen speciesIntestinal ischemia/reperfusion injuryIntestinal ischemia/reperfusionIschemia/reperfusion injuryInhibits neutrophil activationNOS III expressionSuperior mesenteric ischemiaIschemia/reperfusionEndogenous NO formationIntestinal tissue homogenatesWestern blot analysisIntestinal ischemiaMesenteric ischemiaNeutrophil infiltrationR injuryReperfusion injuryDeleterious stimuliNeutrophil activationSynthase activityIntestinal integrityAnimal modelsL-arginine
1997
Mucosal Protection from Intestinal Ischemia–Reperfusion Reduces Oxidant Injury to the Lung
Rossman J, Caty M, Zheng S, Karamanoukian H, Thusu K, Azizkhan R, Dandona P. Mucosal Protection from Intestinal Ischemia–Reperfusion Reduces Oxidant Injury to the Lung. Journal Of Surgical Research 1997, 73: 41-46. PMID: 9441791, DOI: 10.1006/jsre.1997.5196.Peer-Reviewed Original ResearchConceptsIntestinal mucosal injuryLung injuryMucosal injuryOxygenated perfluorocarbonLipid peroxidationDistant organ injuryIntestinal ischemia reperfusionLung lipid peroxidationPortal venous circulationPortal venous effluentOrgan injuryIschemia reperfusionMucosal protectionPortal bloodVenous effluentVenous circulationLung tissueLuminal perfusionIntraluminal oxygenOxidant injurySmall intestineInjuryOxidant generationReactive oxygen speciesPrimary effector