2018
Albendazole Treatment Improves Work Capacity in Women Smallholder Farmers Infected with Hookworm: A Double-Blind Randomized Control Trial.
Salmon M, Salmon C, Masoda M, Salumu JM, Bozzi C, Nieburg P, Harrison LM, Humphries D, Abaca Uvon N, Wendel SK, Trout C, Cappello M. Albendazole Treatment Improves Work Capacity in Women Smallholder Farmers Infected with Hookworm: A Double-Blind Randomized Control Trial. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1419-1426. PMID: 29611504, PMCID: PMC5953358, DOI: 10.4269/ajtmh.17-0403.Peer-Reviewed Original ResearchConceptsWork capacityRandomized Effectiveness TrialSoil-transmitted helminthsHealth of womenStep testPlacebo groupAlbendazole treatmentPrimary outcomeHookworm infectionStep test resultsEffectiveness trialNonsignificant decreaseHeart rateControl trialTreatment groupsIntestinal parasitesPulse rateHookwormTrialsRisk benefitDrug distributionWomenTreatmentAlbendazoleMinutes
2014
Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana
Kotze AC, Dobson RJ, Humphries D, Wilson M, Cappello M. Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana. International Journal For Parasitology Drugs And Drug Resistance 2014, 4: 64-70. PMID: 24596670, PMCID: PMC3940077, DOI: 10.1016/j.ijpddr.2014.01.001.Peer-Reviewed Original ResearchDrug treatmentFaecal egg count reduction testDrug efficacyPre-treatment samplesDrug treatment studiesOverall drug efficacyStudy subjectsSignificant prevalenceEgg excretionPoisson distribution analysisTreatment studiesEfficacySignificant increaseEgg count reduction testSubjectsTreatmentControl measuresSuch subjectsReduction testStoolCasesPoisson distribution methodExcretionPrevalenceQuality control measures
2010
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast
Cho Y, Crichlow GV, Vermeire JJ, Leng L, Du X, Hodsdon ME, Bucala R, Cappello M, Gross M, Gaeta F, Johnson K, Lolis EJ. Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 11313-11318. PMID: 20534506, PMCID: PMC2895110, DOI: 10.1073/pnas.1002716107.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorPeripheral blood mononuclear cellsBlood mononuclear cellsNeuropathic painOpioid withdrawalMIF receptorBronchial asthmaOcular indicationsMononuclear cellsProinflammatory proteinsAntiinflammatory drugsGlial cellsPossible therapeuticsAntiinflammatory activityChemotactic functionNonselective inhibitorAV411Major receptorTautomerase activityReceptorsAllosteric binding siteAntibody experimentsTreatmentAV411 (Ibudilast) and AV1013 are non-competitive inhibitors of macrophage migration inhibitory factor: a novel induced-fit allosteric inhibition mechanism (133.11)
Cho Y, Crichlow G, Vermeire J, Leng L, Du X, Hodsdon M, Bucala R, Cappello M, Gross M, Gaeta F, Johnson K, Lolis E. AV411 (Ibudilast) and AV1013 are non-competitive inhibitors of macrophage migration inhibitory factor: a novel induced-fit allosteric inhibition mechanism (133.11). The Journal Of Immunology 2010, 184: 133.11-133.11. DOI: 10.4049/jimmunol.184.supp.133.11.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorPro-inflammatory proteinsAnti-inflammatory activityAnti-inflammatory drugsNon-selective inhibitorPDE inhibitor rolipramNeuropathic painOpioid withdrawalBronchial asthmaOcular indicationsGlial cellsNon-competitive inhibitorPossible therapeuticsInhibitor rolipramChemotactic functionAV411Tautomerase activityInhibitorsAllosteric binding siteIsobutylmethylxanthineTreatmentAsthmaPain