2021
Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis
Rocha M, Wang D, Avila-Quintero V, Bloch MH, Kaffman A. Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis. Translational Psychiatry 2021, 11: 231. PMID: 33879774, PMCID: PMC8058062, DOI: 10.1038/s41398-021-01352-4.Peer-Reviewed Original ResearchConceptsEarly life stressNovel object recognitionMorris water mazeDifferent rodent modelsContextual fear conditioningMaternal separationHippocampal-dependent memoryVentral hippocampusDorsal hippocampusRodent modelsLife stressAbnormal hippocampal developmentStandardized mean differenceSimilar cognitive deficitsWeb of ScienceModerate effect sizeCFC taskFunctional deficitsFear conditioningInclusion criteriaPreclinical studiesReduced freezingHippocampal developmentLimited beddingWater maze
2020
Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents
Wang D, Levine JLS, Avila-Quintero V, Bloch M, Kaffman A. Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents. Translational Psychiatry 2020, 10: 174. PMID: 32483128, PMCID: PMC7264128, DOI: 10.1038/s41398-020-0856-0.Peer-Reviewed Original ResearchConceptsOpen field testEarly life stressSystematic reviewEffects of MSEffects of ELSAnxiety-like behaviorDefensive behaviorAnxiogenic effectsMaternal separationRodent modelsRatsEarly adversityMiceAbility of MSLife stressLack of standardizationChildhood maltreatmentRodentsExploratory behaviorEffect sizeInconsistent resultsELS modelImportant differencesReviewMS protocol