2022
Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo
Greuter T, Yaqoob U, Gan C, Jalan-Sakrikar N, Kostallari E, Lu J, Gao J, Sun L, Liu M, Sehrawat TS, Ibrahim SH, Furuta K, Nozickova K, Huang BQ, Gao B, Simons M, Cao S, Shah VH. Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo. Journal Of Hepatology 2022, 77: 723-734. PMID: 35421427, PMCID: PMC9391258, DOI: 10.1016/j.jhep.2022.03.029.Peer-Reviewed Original ResearchConceptsFocal adhesionsGlycolytic enzymesIsolated focal adhesionsChromosome conformation captureHistone activation marksChromatin immunoprecipitation analysisConformation captureChIP sequencingActivation marksEpigenetic regulationActin dynamicsHistone acetylationRNA sequencingERT2 miceActin polymerizationEndothelial cellsCXCL1 promoterNovel roleIntegrin β1Druggable targetsInhibition of glycolysisNuclear chromatinGlycolysisAngiocrineEnzyme
2021
Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis
Liu M, Cao S, He L, Gao J, Arab J, Cui H, Xuan W, Gao Y, Sehrawat T, Hamdan F, Ventura-Cots M, Argemi J, Pomerantz W, Johnsen S, Lee J, Gao F, Ordog T, Mathurin P, Revzin A, Bataller R, Yan H, Shah V. Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis. Nature Communications 2021, 12: 4560. PMID: 34315876, PMCID: PMC8316465, DOI: 10.1038/s41467-021-24843-w.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChemokinesCytokinesDisease Models, AnimalEndothelial CellsEnhancer Elements, GeneticEpigenesis, GeneticGene Expression RegulationHepatitis, AlcoholicHistonesHumansLipopolysaccharidesLiverMice, Inbred C57BLNeutrophilsNF-kappa BPromoter Regions, GeneticRNA-SeqSignal TransductionTranscription FactorsTumor Necrosis Factor-alphaConceptsAlcoholic hepatitisLiver sinusoidal endothelial cellsChemokine expressionNeutrophil infiltrationLiver neutrophil infiltrationTNFα/NF-κB signalingNF-κB signalingHuman liver explantsElevated chemokine expressionSinusoidal endothelial cellsCXCL expressionChemokine productionCXCL chemokinesCytokine pathwaysCytokines TNFαInflammatory signalingMurine modelLiver explantsTherapeutic potentialPharmacologic inhibitionExtraterminal (BET) proteinsBET inhibitionHuman liverEndothelial cellsAH treatmentRegulation and functional roles of chemokines in liver diseases
Cao S, Liu M, Sehrawat T, Shah V. Regulation and functional roles of chemokines in liver diseases. Nature Reviews Gastroenterology & Hepatology 2021, 18: 630-647. PMID: 33976393, PMCID: PMC9036964, DOI: 10.1038/s41575-021-00444-2.Peer-Reviewed Original ResearchConceptsLiver diseaseImmune cellsAlcohol-associated liver diseaseOngoing clinical trialsRelevant preclinical studiesFunction of chemokinesLiver infiltrationChemokine transcriptionNonalcoholic steatohepatitisChemokine productionCell-type specific productionClinical trialsInflammatory responseFunctional rolePreclinical studiesChemokine functionAnimal modelsChemokinesChemokine biologyLiver homeostasisTherapeutic opportunitiesDiseaseLiver cellsCellsWeight proteinsCirculating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis
Sehrawat T, Arab J, Liu M, Amrollahi P, Wan M, Fan J, Nakao Y, Pose E, Navarro‐Corcuera A, Dasgupta D, Liao C, He L, Mauer A, Avitabile E, Ventura‐Cots M, Bataller R, Sanyal A, Chalasani N, Heimbach J, Watt K, Gores G, Gines P, Kamath P, Simonetto D, Hu T, Shah V, Malhi H. Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis. Hepatology 2021, 73: 571-585. PMID: 32246544, PMCID: PMC7541595, DOI: 10.1002/hep.31256.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseAlcohol-associated cirrhosisAlcoholic hepatitisAH subjectsHealthy controlsHeavy drinkersLiver diseaseEtiology of ESLDEV concentrationEnd-stage liver disease (MELD) scoreExtracellular vesiclesRisk profilingPathogenesis of AHLiver Disease scoreCholestatic liver diseaseNonalcoholic steatohepatitisRisk stratificationClinical criteriaPrognostic performanceDisease scoreDiagnostic biomarkersDisease controlEV countsDiseaseDrinkers
2020
Hyperammonemic Encephalopathy Exacerbated by Parenteral Nutrition in Fibrolamellar Hepatocellular Carcinoma
Shah P, Cho J, Albitar H, Pajot G, Liu M, Ravi K. Hyperammonemic Encephalopathy Exacerbated by Parenteral Nutrition in Fibrolamellar Hepatocellular Carcinoma. The American Journal Of Medicine 2020, 133: e745-e746. PMID: 32739410, DOI: 10.1016/j.amjmed.2020.06.022.Peer-Reviewed Original ResearchThe knowns and unknowns of treatment for alcoholic hepatitis
Sehrawat T, Liu M, Shah V. The knowns and unknowns of treatment for alcoholic hepatitis. The Lancet Gastroenterology & Hepatology 2020, 5: 494-506. PMID: 32277902, PMCID: PMC7238289, DOI: 10.1016/s2468-1253(19)30326-7.Peer-Reviewed Original ResearchConceptsAlcoholic hepatitisLiver diseaseSevere alcoholic hepatitisInflammatory liver diseaseChronic liver diseaseOngoing clinical trialsEffective medical treatmentMedical therapyHigh morbidityClinical trialsHepatitisPreclinical studiesNew therapiesRapid onsetMedical treatmentMyriad complicationsEffective therapeuticsModest effectivenessAlcohol dependencySeries paperPatientsTherapyDiseaseTreatmentLong term
2019
In Reply: Beta-Blocker Use in Refractory Ascites
Liu M, Simonetto D. In Reply: Beta-Blocker Use in Refractory Ascites. Mayo Clinic Proceedings 2019, 94: 2364-2365. PMID: 31685161, DOI: 10.1016/j.mayocp.2019.09.009.Peer-Reviewed Original ResearchSustained perfusion of revascularized bioengineered livers heterotopically transplanted into immunosuppressed pigs
Shaheen M, Joo D, Ross J, Anderson B, Chen H, Huebert R, Li Y, Amiot B, Young A, Zlochiver V, Nelson E, Mounajjed T, Dietz A, Michalak G, Steiner B, Davidow D, Paradise C, van Wijnen A, Shah V, Liu M, Nyberg S. Sustained perfusion of revascularized bioengineered livers heterotopically transplanted into immunosuppressed pigs. Nature Biomedical Engineering 2019, 4: 437-445. PMID: 31611679, PMCID: PMC7153989, DOI: 10.1038/s41551-019-0460-x.Peer-Reviewed Original ResearchConceptsHuman endothelial cellsEndothelial cellsSustained perfusionImmune responseContinuous perfusionNormal liver tissueHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsImmunosuppression protocolsAnticoagulation therapyVein endothelial cellsImmunosuppressed pigsEndothelial markersLiver sinusoidsPerfusionLiver tissueHuman liverLiverBlood perfusionHeterotopic implantationMain predictorsLiver scaffoldsPigsPorcine liverDaysPortal Hypertension and Related Complications: Diagnosis and Management
Simonetto D, Liu M, Kamath P. Portal Hypertension and Related Complications: Diagnosis and Management. Mayo Clinic Proceedings 2019, 94: 714-726. PMID: 30947834, DOI: 10.1016/j.mayocp.2018.12.020.Peer-Reviewed Original Research
2016
Chronic hepatitis B: immune pathogenesis and emerging immunotherapeutics
Chang K, Liu M. Chronic hepatitis B: immune pathogenesis and emerging immunotherapeutics. Current Opinion In Pharmacology 2016, 30: 93-105. PMID: 27570126, DOI: 10.1016/j.coph.2016.07.013.Peer-Reviewed Original ResearchConceptsImmune modulatory approachesChronic hepatitis B.Chronic viral infectionsHost immune componentsImmune pathogenesisHBV infectionFunctional cureHepatitis BHepatitis B.Tumor immunotherapyModulatory approachesImmune componentsImmune interactionsClinical developmentViral infectionDisease pathogenesisNatural historyPathogenic responsesAspects of hostImmunotherapeuticsPathogenesisTumor therapyInfectionImmunotherapyTherapy
2014
Polyreactivity and Autoreactivity among HIV-1 Antibodies
Liu M, Yang G, Wiehe K, Nicely N, Vandergrift N, Rountree W, Bonsignori M, Alam S, Gao J, Haynes B, Kelsoe G. Polyreactivity and Autoreactivity among HIV-1 Antibodies. Journal Of Virology 2014, 89: 784-798. PMID: 25355869, PMCID: PMC4301171, DOI: 10.1128/jvi.02378-14.Peer-Reviewed Original ResearchConceptsNeutralization breadthMembrane-proximal external regionMultiple HIV-1 cladesCD4 T-cell depletionChronic antigen exposureHIV-1 AbT-cell depletionHIV-1 infectionHIV-1 vaccineHIV-1 antibodiesHIV-1 cladesHIV-1 CD4HIV-1 envelopeHIV-1 neutralizationAntigen exposureChronic inflammationHumoral responseInfected patientsProtective vaccineImmune regulationHIV-1AutoreactivityAutoreactive propertiesAg exposureHost AgAn autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1
Bonsignori M, Wiehe K, Grimm S, Lynch R, Yang G, Kozink D, Perrin F, Cooper A, Hwang K, Chen X, Liu M, McKee K, Parks R, Eudailey J, Wang M, Clowse M, Criscione-Schreiber L, Moody M, Ackerman M, Boyd S, Gao F, Kelsoe G, Verkoczy L, Tomaras G, Liao H, Kepler T, Montefiori D, Mascola J, Haynes B. An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. Journal Of Clinical Investigation 2014, 124: 1835-1843. PMID: 24614107, PMCID: PMC3973118, DOI: 10.1172/jci73441.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SequenceAntibodies, AntinuclearAntibodies, NeutralizingAutoantibodiesB-LymphocytesBase SequenceDNAFemaleHIV AntibodiesHIV Envelope Protein gp120HIV InfectionsHIV-1HumansImmunologic MemoryLupus Erythematosus, SystemicModels, MolecularMolecular Sequence DataMultiprotein ComplexesMutationProtein ConformationSequence Homology, Amino AcidSequence Homology, Nucleic AcidViral LoadConceptsHIV-1-infected individualsAnti-dsDNA reactivityHeavy chain complementarity-determining region 3Autoimmune diseasesB cellsHIV-1 envelope glycoprotein 120HIV-1-neutralizing antibodiesImmune tolerance mechanismsMemory B cellsEnvelope glycoprotein 120CD4 binding siteComplementarity-determining region 3Somatic mutationsCD4bs bnAbsHLA phenotypesViral loadAutoreactive antibodiesBnAb developmentChain complementarity-determining region 3Neutralization breadthGlycoprotein 120HIV-1Patient plasmaHuman antigensBnAbs
2013
Radiology Education in China
Wang Y, Liu M, Jin L, Lungren M, Grimm L, Zhang Z, Maxfield C. Radiology Education in China. Journal Of The American College Of Radiology 2013, 10: 213-219. PMID: 23571062, DOI: 10.1016/j.jacr.2012.11.006.Peer-Reviewed Original Research