Polyreactivity and Autoreactivity among HIV-1 Antibodies
Liu M, Yang G, Wiehe K, Nicely N, Vandergrift N, Rountree W, Bonsignori M, Alam S, Gao J, Haynes B, Kelsoe G. Polyreactivity and Autoreactivity among HIV-1 Antibodies. Journal Of Virology 2014, 89: 784-798. PMID: 25355869, PMCID: PMC4301171, DOI: 10.1128/jvi.02378-14.Peer-Reviewed Original ResearchMeSH KeywordsAutoantibodiesHIV AntibodiesHIV-1HumansMicroarray AnalysisProtein Array AnalysisProtein BindingConceptsNeutralization breadthMembrane-proximal external regionMultiple HIV-1 cladesCD4 T-cell depletionChronic antigen exposureHIV-1 AbT-cell depletionHIV-1 infectionHIV-1 vaccineHIV-1 antibodiesHIV-1 cladesHIV-1 CD4HIV-1 envelopeHIV-1 neutralizationAntigen exposureChronic inflammationHumoral responseInfected patientsProtective vaccineImmune regulationHIV-1AutoreactivityAutoreactive propertiesAg exposureHost Ag