2021
Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis
Sehrawat T, Arab J, Liu M, Amrollahi P, Wan M, Fan J, Nakao Y, Pose E, Navarro‐Corcuera A, Dasgupta D, Liao C, He L, Mauer A, Avitabile E, Ventura‐Cots M, Bataller R, Sanyal A, Chalasani N, Heimbach J, Watt K, Gores G, Gines P, Kamath P, Simonetto D, Hu T, Shah V, Malhi H. Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis. Hepatology 2021, 73: 571-585. PMID: 32246544, PMCID: PMC7541595, DOI: 10.1002/hep.31256.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseAlcohol-associated cirrhosisAlcoholic hepatitisAH subjectsHealthy controlsHeavy drinkersLiver diseaseEtiology of ESLDEV concentrationEnd-stage liver disease (MELD) scoreExtracellular vesiclesRisk profilingPathogenesis of AHLiver Disease scoreCholestatic liver diseaseNonalcoholic steatohepatitisRisk stratificationClinical criteriaPrognostic performanceDisease scoreDiagnostic biomarkersDisease controlEV countsDiseaseDrinkers
2020
Esophageal Varices: Primary Prophylaxis and Prevention and Management of Rebleeding
Liu M, Hilscher M, Kamath P. Esophageal Varices: Primary Prophylaxis and Prevention and Management of Rebleeding. Current Hepatology Reports 2020, 19: 213-225. DOI: 10.1007/s11901-020-00525-x.Peer-Reviewed Original ResearchPortal hypertensionGastroesophageal variceal hemorrhageChronic liver diseaseManagement of patientsPrimary prophylaxisVariceal hemorrhageGastric varicesSecondary preventionAcute managementLiver diseaseRisk stratificationHigh morbidityPrimary preventionPatient outcomesClinical studiesDifferential diagnosisHypertensionDiagnostic criteriaNatural historySummaryThis reviewPreventionVaricesImportant manifestationFurther researchRebleeding