Protein Requirements for Critically Ill Patients With Renal and Liver Failure
Patel J, McClain C, Sarav M, Hamilton‐Reeves J, Hurt R. Protein Requirements for Critically Ill Patients With Renal and Liver Failure. Nutrition In Clinical Practice 2017, 32: 101s-111s. PMID: 28208022, DOI: 10.1177/0884533616687501.Peer-Reviewed Original ResearchConceptsDecompensated liver cirrhosisAcute kidney injuryAcute liver failureNegative nitrogen balanceMuscle wastingRenal replacement therapyCritically ill patientsRespiratory failureLiver dysfunctionReplacement therapyKidney injuryLiver failureLiver cirrhosisAmino acid lossesICU admissionIncreased riskOptimal protein supplementationSevere formIll patientsCritical illnessNitrogen balanceProtein abnormalitiesAssociated with proteolysisProtein requirementsAcid lossAcquired Amino Acid Deficiencies: A Focus on Arginine and Glutamine
Morris C, Hamilton‐Reeves J, Martindale R, Sarav M, Gautier J. Acquired Amino Acid Deficiencies: A Focus on Arginine and Glutamine. Nutrition In Clinical Practice 2017, 32: 30s-47s. PMID: 28388380, DOI: 10.1177/0884533617691250.Peer-Reviewed Original ResearchConceptsLow arginine bioavailabilityT cell dysfunctionAmino acidsSickle cell diseaseArginine bioavailabilityPulmonary hypertensionT cellsTherapeutic optionsConditionally essential amino acidsDeficiency syndromeCystic fibrosisEndothelial dysfunctionAcute asthmaAt-risk populationsCatabolic stateCell diseaseClinical scenariosAmino acid synthesisCritical illnessConditions of stressGastrointestinal disordersAcid deficiencyCardiovascular diseaseCatabolism of arginineSynthesized de novo