2024
The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review
Jegede O, De Aquino J, Hsaio C, Caldwell E, Funaro M, Petrakis I, Muvvala S. The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review. Journal Of Addiction Medicine 2024, 18: 499-510. PMID: 39356620, PMCID: PMC11449257, DOI: 10.1097/adm.0000000000001356.Peer-Reviewed Original ResearchNonmedical opioid useOpioid use disorderOpioid useWithdrawal symptomsTreatment outcomesSymptoms prior to treatmentUse disorderRisk of precipitated withdrawalLow-dose buprenorphineSynthetic opioidsPotency synthetic opioidsConclusions Current evidencePrecipitated withdrawalRisk of overdoseDosing strategiesPharmacological interactionsClinical significanceDecreased riskWeb of ScienceOpioidInclusion criteriaCurrent evidenceClinical implicationsMOUDPainThe Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews
Kitaneh R, Jalilian-Khave L, Ysrayl B, Borelli A, Funaro M, Potenza M, Angarita G. The Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews. Current Behavioral Neuroscience Reports 2024, 11: 164-181. DOI: 10.1007/s40473-024-00278-7.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorder symptomsTreatment of attention-deficit hyperactivity disorderSeverity of ADHD symptomsAttention-deficit hyperactivity disorderManagement of attention-deficit/hyperactivity disorderOutcomes of attention-deficit/hyperactivity disorderOverview of systematic reviewsADHD symptomsSerum vitamin D levelsHyperactivity disorderInclusion criteriaMeta-analysesVitamin D levelsBrain regionsMaternal serum vitamin D levelsPrenatal vitamin D levelsAssociated with improvementsNeurotransmitter regulationRisk of offspringVitamin D supplementationD levelsWell-powered randomized clinical trialsSystematic literature searchSummaryThe literature
2022
Multidimensional assessment of access to medications for opioid use disorder across urban and rural communities: A scoping review
Bommersbach T, Justen M, Bunting A, Funaro M, Winstanley E, Joudrey P. Multidimensional assessment of access to medications for opioid use disorder across urban and rural communities: A scoping review. International Journal Of Drug Policy 2022, 112: 103931. PMID: 36563489, DOI: 10.1016/j.drugpo.2022.103931.Peer-Reviewed Original ResearchConceptsOpioid use disorderMOUD accessUse disordersPatient's perspectiveMajority of patientsTailoring of interventionsPatient-centered accessMOUD deliveryTreatment outcomesInclusion criteriaPatient's abilityMOUD servicesDimensions of accessElectronic databasesStudy characteristicsQualitative synthesisUnique articlesRural communitiesStudy sampleHealthcare systemCommunity-engaged researchAccess dimensionsMedicationsDisordersCOVID-19Racial and ethnic differences in alcohol, cannabis, and illicit substance use treatment: a systematic review and narrative synthesis of studies done in the USA
Jordan A, Quainoo S, Nich C, Babuscio TA, Funaro MC, Carroll KM. Racial and ethnic differences in alcohol, cannabis, and illicit substance use treatment: a systematic review and narrative synthesis of studies done in the USA. The Lancet Psychiatry 2022, 9: 660-675. PMID: 35752192, DOI: 10.1016/s2215-0366(22)00160-2.Peer-Reviewed Original ResearchConceptsSubstance use outcomesTreatment initiationJoanna Briggs Institute appraisal toolsSystematic reviewSubstance use disordersSignificant differencesSubstance use treatmentDissemination of treatmentUncontrolled trialsClinical trialsBaseline differencesStudy qualityInclusion criteriaUse disordersRCTsNarrative synthesisSocial determinantsUse treatmentAppraisal toolLatinx adultsEthnic differencesEthnic populationsOutcomesTrialsLatinx populationsEvidence-based service delivery interventions for testing, linking, treating, and retaining children and adolescents living with HIV in primary health care settings: Protocol for a systematic review
Putta N, Hansen CE, Funaro MC, Campbell M, Essajee S, Mbori-Ngacha D, Frimpong S, Wang SY, Paintsil E. Evidence-based service delivery interventions for testing, linking, treating, and retaining children and adolescents living with HIV in primary health care settings: Protocol for a systematic review. PLOS ONE 2022, 17: e0269063. PMID: 35709211, PMCID: PMC9202933, DOI: 10.1371/journal.pone.0269063.Peer-Reviewed Original ResearchConceptsSystematic reviewPrimary health care settingsService delivery interventionsMeta-analysis protocolPairs of reviewersHealth care providersEvidence-based service deliveryPreferred Reporting ItemsHealth care settingsRandom-effects modelComprehensive search strategyImmunologic outcomesPregnant womenCochrane LibraryTreatment optionsDelivery interventionsRetention of childrenInclusion criteriaCare settingsCare providersHIVRegistration numberReporting ItemsCare deliveryNarrative synthesis
2021
Which Maturation Indicator is Most Accurate in Predicting Cessation of Facial Growth? A Systematic Review of the Literature
Reategui A, Phillips S, Khetpal S, Parsaei Y, Funaro M, Mukherjee T, Lopez J, Steinbacher DM. Which Maturation Indicator is Most Accurate in Predicting Cessation of Facial Growth? A Systematic Review of the Literature. Journal Of Craniofacial Surgery 2021, 33: 764-768. PMID: 34611106, DOI: 10.1097/scs.0000000000008253.Peer-Reviewed Original ResearchConceptsSystematic reviewJoanna Briggs Institute Critical Appraisal ChecklistQuality of evidenceMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsCritical Appraisal ChecklistGrowth maturationSkeletal maturity indicatorsCohort studyPediatric patientsSurgical timingProspective studySurgical interventionInclusion criteriaMenses onsetPaucity of articlesReporting ItemsAppraisal ChecklistSkeletal maturityPredictive indicatorSystematic searchGoogle ScholarLack of consensusFacial growthThe role of social network support in treatment outcomes for medication for opioid use disorder: A systematic review
Kumar N, Oles W, Howell BA, Janmohamed K, Lee ST, Funaro MC, O'Connor PG, Alexander M. The role of social network support in treatment outcomes for medication for opioid use disorder: A systematic review. Journal Of Substance Use And Addiction Treatment 2021, 127: 108367. PMID: 34134871, PMCID: PMC9022048, DOI: 10.1016/j.jsat.2021.108367.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersTreatment outcomesMedication treatmentMOUD treatmentSystematic reviewOpioid use disorder treatmentSocial network supportPositive social support networksUse disorder treatmentPatients' oddsOpioid deathsPatient populationSuccessful treatmentOpioid epidemicInclusion criteriaResearch DatabaseElectronic research databasesHealthy behaviorsDisorder treatmentTools physiciansTargeted interventionsDisordersMedicationsTreatmentAbsence seizures and their relationship to depression and anxiety: Evidence for bidirectionality
Gruenbaum BF, Sandhu MRS, Bertasi RAO, Bertasi TGO, Schonwald A, Kurup A, Gruenbaum SE, Freedman IG, Funaro MC, Blumenfeld H, Sanacora G. Absence seizures and their relationship to depression and anxiety: Evidence for bidirectionality. Epilepsia 2021, 62: 1041-1056. PMID: 33751566, PMCID: PMC8443164, DOI: 10.1111/epi.16862.Peer-Reviewed Original ResearchConceptsAbsence seizuresMood disordersChildhood epilepsyCommon manifestationInclusion criteriaEffective treatmentGenetic predispositionGreater oddsAnimal modelsAnatomical pathwaysSystematic reviewDepressionShort lossDisordersPatientsBidirectional relationshipSeizuresCurrent literatureAnxietySocial impairmentFurther researchReviewEpilepsyStrong correlationImpairmentAn Evaluation of Opioid Use in Black Communities: A Rapid Review of the Literature.
Jordan A, Mathis M, Haeny A, Funaro M, Paltin D, Ransome Y. An Evaluation of Opioid Use in Black Communities: A Rapid Review of the Literature. Harvard Review Of Psychiatry 2021, 29: 108-130. PMID: 33666395, PMCID: PMC8335706, DOI: 10.1097/hrp.0000000000000285.Peer-Reviewed Original ResearchConceptsOpioid useRapid reviewSocial determinantsUse of opioidsTreatment-seeking patternsClear inclusion criteriaOpioid overdose deathsFull-text reviewComprehensive search strategyHealth care systemGrey literature sourcesClinician prescribingTreatment initiationInclusion criteriaOverdose deathsEpidemiologic SurveyClinical practiceHealth outcomesOpioid crisisOpioidsNarrative summaryTraditional health care systemCare systemSystematic review methodsBlack individuals
2020
A systematic review of ketamine for the treatment of depression among older adults
Gupta A, Dhar R, Patadia P, Funaro M, Bhattacharya G, Farheen SA, Tampi RR. A systematic review of ketamine for the treatment of depression among older adults. International Psychogeriatrics 2020, 33: 179-191. PMID: 32600480, DOI: 10.1017/s1041610220000903.Peer-Reviewed Educational MaterialsConceptsUse of ketaminePrimary outcome measureTreatment of depressionOlder adultsAdverse effectsOutcome measuresMontgomery-Asberg Depression Rating Scale scoreDepression Rating Scale scoresBenefits of ketamineCognitive adverse effectsRating Scale scoresEsketamine groupPlacebo groupRemission rateIntranasal ketamineKetamine administrationMADRS scoresInclusion criteriaDepressive symptomsCurrent evidenceScale scoreDepression symptomsKetamineSystematic reviewNegative trialsSystematic review of benzodiazepines for anxiety disorders in late life.
Gupta A, Bhattacharya G, Farheen SA, Funaro M, Balasubramaniam M, Young J, Tampi DJ, Tampi RR. Systematic review of benzodiazepines for anxiety disorders in late life. Annals Of Clinical Psychiatry 2020, 32: 114-127. PMID: 32343283.Peer-Reviewed Educational MaterialsConceptsAnxiety disordersSystematic reviewOlder adultsTolerability of benzodiazepinesCochrane Central RegisterMild adverse effectsLater lifeEnglish-language articlesTreatment of anxietyLong-term useWeb of ScienceTolerability dataCentral RegisterControlled TrialsCochrane DatabaseOvid EmbaseLong-term benefitsOvid MEDLINEInclusion criteriaEligible articlesBenzodiazepinesDecreased anxietyStudy periodAdverse effectsTrialsRelevance of Microvascular Flow Assessments in Critically Ill Neonates and Children: A Systematic Review.
Maitoza LA, Neeman E, Funaro M, Pierce RW. Relevance of Microvascular Flow Assessments in Critically Ill Neonates and Children: A Systematic Review. Pediatric Critical Care Medicine 2020, 21: 373-384. PMID: 31834246, PMCID: PMC10061570, DOI: 10.1097/pcc.0000000000002201.Peer-Reviewed Original ResearchConceptsIll childrenMicrovascular flowSystematic reviewMicrocirculatory dysfunctionIll neonatesMicrocirculatory changesBlood flowImpact of patientMicrovascular blood flowMicrocirculatory blood flowFull-text reviewWeb of ScienceMacrovascular functionPatients 0Critical illnessEffect of ageSuch patientsMedical managementPoor outcomeBirth weightMicrocirculatory variablesClinical endpointsInclusion criteriaNeonatesMacrocirculatory variables
2018
Tight junction structure, function, and assessment in the critically ill: a systematic review
Vermette D, Hu P, Canarie MF, Funaro M, Glover J, Pierce RW. Tight junction structure, function, and assessment in the critically ill: a systematic review. Intensive Care Medicine Experimental 2018, 6: 37. PMID: 30259344, PMCID: PMC6158145, DOI: 10.1186/s40635-018-0203-4.Peer-Reviewed Original ResearchCritical illnessSystematic reviewTight junctionsGut bacterial translocationMultiple organ failureFull-text reviewEndothelial tight junctionsEndothelial barrier integrityCritical disease statesTJ structureBacterial translocationCardiac failureClinical outcomesOrgan failurePulmonary edemaBarrier disruptionPROSPERO databaseResultsA totalBarrier dysfunctionPulmonary pathologyTherapeutic advancesCapillary leakInclusion criteriaGastrointestinal epitheliumTJ breakdown