Tight junction structure, function, and assessment in the critically ill: a systematic review
Vermette D, Hu P, Canarie MF, Funaro M, Glover J, Pierce RW. Tight junction structure, function, and assessment in the critically ill: a systematic review. Intensive Care Medicine Experimental 2018, 6: 37. PMID: 30259344, PMCID: PMC6158145, DOI: 10.1186/s40635-018-0203-4.Peer-Reviewed Original ResearchCritical illnessSystematic reviewTight junctionsGut bacterial translocationMultiple organ failureFull-text reviewEndothelial tight junctionsEndothelial barrier integrityCritical disease statesTJ structureBacterial translocationCardiac failureClinical outcomesOrgan failurePulmonary edemaBarrier disruptionPROSPERO databaseResultsA totalBarrier dysfunctionPulmonary pathologyTherapeutic advancesCapillary leakInclusion criteriaGastrointestinal epitheliumTJ breakdown