2020
Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota
Brugger SD, Eslami SM, Pettigrew MM, Escapa IF, Henke MT, Kong Y, Lemon KP. Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota. MSphere 2020, 5: 10.1128/msphere.00852-20. PMID: 32907957, PMCID: PMC7485692, DOI: 10.1128/msphere.00852-20.Peer-Reviewed Original ResearchConceptsMicrobe-microbe interactionsHuman nasal microbiotaGenomic analysisPhenotypic interactionsBiosynthetic gene clusterSmall genomesNasal microbiotaGene clusterAccessory genomeKey nutrientsNew insightsGenomic capacityBacterial residentsPathogenic speciesNasal microbiota compositionBeneficial bacteriumFunctional assaysDiverse repertoireHuman hostGenomeSpeciesAcid productionMicrobiotaNasal bacteriaBacteria
2016
Association of sputum microbiota profiles with severity of community-acquired pneumonia in children
Pettigrew MM, Gent JF, Kong Y, Wade M, Gansebom S, Bramley AM, Jain S, Arnold SL, McCullers JA. Association of sputum microbiota profiles with severity of community-acquired pneumonia in children. BMC Infectious Diseases 2016, 16: 317. PMID: 27391033, PMCID: PMC4939047, DOI: 10.1186/s12879-016-1670-4.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaCAP severityMicrobiota profilesClinical courseRespiratory microbiotaPediatric community-acquired pneumoniaIntensive care unit admissionNasopharyngeal/oropharyngeal samplesCare unit admissionOdds of lengthInduced sputum samplesRespiratory tract microbiotaOP samplesRibosomal RNA sequencingUnit admissionDecreased oddsSputum samplesChildren 6Oropharyngeal samplesMicrobiota influenceChildren 5Logistic regressionSputumSeverityPneumonia
2012
Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media
Ruohola A, Pettigrew MM, Lindholm L, Jalava J, Räisänen KS, Vainionpää R, Waris M, Tähtinen PA, Laine MK, Lahti E, Ruuskanen O, Huovinen P. Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media. Journal Of Infection 2012, 66: 247-254. PMID: 23266462, PMCID: PMC3571106, DOI: 10.1016/j.jinf.2012.12.002.Peer-Reviewed Original ResearchConceptsRisk of AOMAcute otitis mediaMiddle ear effusionAOM groupRespiratory virusesAOM pathogensAcute symptomsOtitis mediaEar effusionM. catarrhalisAcute inflammatory signsNasopharyngeal bacterial colonizationRespiratory tract infectionsOtoscopic signsTract infectionsInflammatory signsNasopharyngeal samplesSymptomatic childrenNasopharyngeal bacteriaH. influenzaePneumatic otoscopyS. pneumoniaeViral interactionsBacterial colonizationEffusionUpper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children
Pettigrew MM, Laufer AS, Gent JF, Kong Y, Fennie KP, Metlay JP. Upper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children. Applied And Environmental Microbiology 2012, 78: 6262-6270. PMID: 22752171, PMCID: PMC3416608, DOI: 10.1128/aem.01051-12.Peer-Reviewed Original ResearchConceptsAcute otitis mediaAntibiotic useS. pneumoniaeHealthy childrenM. catarrhalisH. influenzaeAcute otitis media pathogensConcurrent acute otitis mediaUpper respiratory tract infectionRespiratory tract infectionsOtitis media pathogensUpper respiratory tractCross-sectional studyYears of ageAOM pathogensTract infectionsOtitis mediaMoraxella catarrhalisRespiratory tractReal-time PCRNasal swabsSick childrenPrevention strategiesHaemophilus influenzaeStreptococcus pneumoniae
2011
Microbial Communities of the Upper Respiratory Tract and Otitis Media in Children
Laufer AS, Metlay JP, Gent JF, Fennie KP, Kong Y, Pettigrew MM. Microbial Communities of the Upper Respiratory Tract and Otitis Media in Children. MBio 2011, 2: 10.1128/mbio.00245-10. PMID: 21285435, PMCID: PMC3031303, DOI: 10.1128/mbio.00245-10.Peer-Reviewed Original ResearchConceptsOtitis mediaUpper respiratory tractS. pneumoniaeRespiratory tractOtitis media treatmentRespiratory virus seasonS. pneumoniae colonizationOtitis media pathogensCross-sectional studyOtitis media susceptibilityPneumoniae colonizationDecreased riskPneumococcal colonizationNasal swabsFrequent causePrevention strategiesStreptococcus pneumoniaeDemographic dataProtective floraPneumoniaeSwabsChildrenCausal pathwaysTractRisk
2004
An array of diverse microbial genomes
Pettigrew MM. An array of diverse microbial genomes. Trends In Biotechnology 2004, 22: 491-493. PMID: 15450738, DOI: 10.1016/j.tibtech.2004.08.008.Peer-Reviewed Original Research