2023
A review of the impact of energy balance on triple-negative breast cancer
Akingbesote N, Owusu D, Liu R, Cartmel B, Ferrucci L, Zupa M, Lustberg M, Sanft T, Blenman K, Irwin M, Perry R. A review of the impact of energy balance on triple-negative breast cancer. JNCI Monographs 2023, 2023: 104-124. PMID: 37139977, DOI: 10.1093/jncimonographs/lgad011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTriple-negative breast cancerInterventional studyBreast cancerCancer treatmentClinical interventional studyClinical observationalImmune activationCancer outcomesCancer careClinical studiesOverall healthEnergy intakeNarrative reviewCancer cellsEnergy expenditureCancerTreatmentEnergy balanceOutcomesExerciseReviewDetrimental effectsImmunotherapyStudyIntakeTranslating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer
Garcia M, Schadler K, Chandra J, Clinton S, Courneya K, Cruz‐Monserrate Z, Daniel C, Dannenberg A, Demark‐Wahnefried W, Dewhirst M, Fabian C, Hursting S, Irwin M, Iyengar N, McQuade J, Schmitz K, Basen‐Engquist K. Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer. CA A Cancer Journal For Clinicians 2023, 73: 425-442. PMID: 36825928, PMCID: PMC11225601, DOI: 10.3322/caac.21773.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsParallel studyHealthy survivorshipCancer outcomesDietary intakePhysical activityAnimal modelsClinical observationsAnimal studiesBody compositionCancer developmentPractice changeCancerPopulation studiesCancer researchEnergy balance researchEnergy balancePatientsSubstantial benefitsClinicStudyIntakeA qualitative study identifying challenges resulting from complex evidence on lifestyle factors and cancer: perspectives from Black and Latina cancer survivors and healthcare providers
Pichardo M, Irwin M, Sanft T, Ferrucci L, Ginader A, Nguyen T, Esserman D, Cartmel B, Molina Y. A qualitative study identifying challenges resulting from complex evidence on lifestyle factors and cancer: perspectives from Black and Latina cancer survivors and healthcare providers. Supportive Care In Cancer 2023, 31: 111. PMID: 36633678, PMCID: PMC9912693, DOI: 10.1007/s00520-022-07539-9.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsOncology healthcare providersCancer survivorsLifestyle behaviorsHealthcare providersGeneric messagingEvidence-based knowledgeFemale breast cancer survivorsHealthcare provider counselingHealthy lifestyle guidelinesPatient-level barriersHealthy lifestyle behaviorsLifestyle guidelinesProvider counselingLifestyle factorsOncology careCancer outcomesBreast cancerConsistency of evidenceCurrent evidenceAvailable evidenceSurvivorsCancer diagnosisLevel barriersCancer
2022
Marital Status, Living Arrangement, and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings from CALGB 89803 (Alliance)
Lee S, Ma C, Zhang S, Ou FS, Bainter TM, Niedzwiecki D, Saltz LB, Mayer RJ, Whittom R, Hantel A, Benson A, Atienza D, Kindler H, Gross CP, Irwin ML, Meyerhardt JA, Fuchs CS. Marital Status, Living Arrangement, and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings from CALGB 89803 (Alliance). The Oncologist 2022, 27: e494-e505. PMID: 35641198, PMCID: PMC9177101, DOI: 10.1093/oncolo/oyab070.Peer-Reviewed Original ResearchConceptsStage III colon cancerRecurrence-free survivalOverall survivalColon cancerCALGB 89803Marital statusAdjuvant chemotherapy trialsColorectal cancer outcomesColon cancer mortalityTime of enrollmentLiving arrangementsChemotherapy trialsSocial support servicesSurvival outcomesCancer mortalityPatient populationCancer outcomesClinical trialsSpouse/partnerWorse outcomesCancer recurrenceNursing homesPatientsSecondary analysisCancer
2021
The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention
Delahanty LM, Wadden TA, Goodwin PJ, Alfano CM, Thomson CA, Irwin ML, Neuhouser ML, Crane TE, Frank E, Spears PA, Gillis BP, Hershman DL, Paskett ED, Hopkins J, Bernstein V, Stearns V, White J, Hudis C, Winer EP, Carey L, Partridge AH, Ligibel JA. The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention. Obesity 2021, 30: 28-38. PMID: 34932888, PMCID: PMC9186690, DOI: 10.1002/oby.23287.Peer-Reviewed Original ResearchConceptsWeight loss interventionWeight loss trialLifestyle interventionHealth education materialsWeight lossLoss trialPhysical activityInvasive disease-free survivalDisease-free survivalBreast cancer patientsBreast cancer diagnosisCare of thousandsEducation materialsBaseline weightCancer outcomesCancer patientsHealth coachesCancer recurrenceBreast cancerCaloric restrictionStage IITrialsCancer diagnosisInterventionWomenAssociation of Epigenetic Age Acceleration With Risk Factors, Survival, and Quality of Life in Patients With Head and Neck Cancer
Xiao C, Miller AH, Peng G, Levine ME, Conneely KN, Zhao H, Eldridge RC, Wommack EC, Jeon S, Higgins KA, Shin DM, Saba NF, Smith AK, Burtness B, Park HS, Irwin ML, Ferrucci LM, Ulrich B, Qian DC, Beitler JJ, Bruner DW. Association of Epigenetic Age Acceleration With Risk Factors, Survival, and Quality of Life in Patients With Head and Neck Cancer. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: 157-167. PMID: 33882281, PMCID: PMC8802868, DOI: 10.1016/j.ijrobp.2021.04.002.Peer-Reviewed Original ResearchConceptsProgression-free survivalBody mass indexQuality of lifeHigher epigenetic age accelerationTreatment-related symptomsOverall survivalEpigenetic age accelerationRadiation therapyRisk factorsClinical characteristicsNeck cancerAge accelerationWorse overall survivalHuman papilloma virusFaster biological agingAdverse eventsDistant metastasisLifestyle factorsMass indexCancer outcomesBlood biomarkersPapilloma virusFunctional assessmentHigher HRPatientsRace, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance)
Lee S, Zhang S, Ma C, Ou FS, Wolfe EG, Ogino S, Niedzwiecki D, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson A, Atienza D, Messino M, Kindler H, Venook A, Gross CP, Irwin ML, Meyerhardt JA, Fuchs CS. Race, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance). JNCI Cancer Spectrum 2021, 5: pkab034-. PMID: 34104867, PMCID: PMC8178799, DOI: 10.1093/jncics/pkab034.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlack PeopleChemotherapy, AdjuvantColonic NeoplasmsConfidence IntervalsDietDisease-Free SurvivalFemaleHealth Services AccessibilityHumansIncomeLife StyleMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalNeoplasm StagingProportional Hazards ModelsProspective StudiesWhite PeopleConceptsAdjusted hazard ratioDisease-free survivalRecurrence-free survivalColon cancer patientsHome zip codeMedian household incomeCALGB 89803Hazard ratioOverall survivalCancer patientsStage III colon cancer patientsStage III colon cancerPatient's home zip codeAdjuvant chemotherapy trialsStudy of patientsColon cancer outcomesHealth care accessChemotherapy trialsStudy enrollmentBlack patientsCancer outcomesLifestyle factorsLowest quartileObservational studyPatients
2020
Energetics
Ferrucci L, Irwin M. Energetics. 2020, 303-320. DOI: 10.1007/978-3-030-42011-6_15.Peer-Reviewed Original ResearchWeight loss interventionCancer riskLoss interventionCancer outcomesRisk factorsReduced cancer riskIndependent risk factorEnergy balance interventionsDifferent cancer sitesDiet interventionPhysical inactivityDifferent cancer typesSurrogate markerCancer sitesBalance interventionsPhysical activityNew therapiesPoor dietObesityVaried age groupsAge groupsCancer typesCancer developmentMortalityWeight loss
2012
Benefits of Aerobic and Resistance Exercise for Cancer Survivors
Irwin M. Benefits of Aerobic and Resistance Exercise for Cancer Survivors. Energy Balance And Cancer 2012, 199-214. DOI: 10.1007/978-1-4614-4493-0_12.Peer-Reviewed Original ResearchCancer outcomesPhysical activityCancer survivorsResistance exerciseSpecific cancer outcomesCancer diagnosisBenefits of exerciseQuality of lifeDiagnosis of cancerFuture exercise interventionsExercise interventionPhysical functioningLower riskSide effectsMore effective strategiesDiagnosisOutcomesExerciseCancerSurvivorsOverall qualitySurgeryRecurrenceEffective strategyActivity
2008
Impact of Nutrition and Exercise on Cancer Survival
Irwin ML, Mayne ST. Impact of Nutrition and Exercise on Cancer Survival. The Cancer Journal 2008, 14: 435-441. PMID: 19060611, DOI: 10.1097/ppo.0b013e31818daeee.Peer-Reviewed Original ResearchConceptsCancer survivorsSupplement useCancer survivalAdverse prognostic factorPhysical activity recommendationsNutrient supplement useAmerican Cancer SocietyLifestyle-based approachLong-term survivalImpact of nutritionLifestyle interventionPrognostic factorsRandomized trialsCancer outcomesPhysical inactivityActivity recommendationsCurrent guidelinesNumber of menCancer SocietyPhysical activityWeight gainAvailable evidenceSurvivorsSurvivalObesity