2007
Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea
Kryger M, Wang-Weigand S, Roth T. Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea. Sleep And Breathing 2007, 11: 159-164. PMID: 17294232, DOI: 10.1007/s11325-006-0096-4.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaNext-day residual effectsApnea-hypopnea indexSleep apneaPost-sleep questionnaireAdverse eventsSelective MT1/MT2 receptor agonistMT1/MT2 receptor agonistMT2 receptor agonistSafety of ramelteonUrinary tract infectionArterial oxygen saturationControl of breathingRespiratory inductance plethysmographyRamelteon groupPlacebo groupTract infectionsCrossover studyWashout periodDepressant effectSleep QuestionnaireHypopneic eventsRespiratory effortInsomnia treatmentOxygen saturation
2006
Adaptive servo-ventilation in patients with idiopathic Cheyne-Stokes breathing.
Banno K, Okamura K, Kryger MH. Adaptive servo-ventilation in patients with idiopathic Cheyne-Stokes breathing. Journal Of Clinical Sleep Medicine 2006, 2: 181-6. PMID: 17557493, DOI: 10.5664/jcsm.26514.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureCheyne-Stokes breathingHours of sleepHeart failureBreathing patternCentral sleep apneaPositive airway pressurePeriodic breathing patternAbnormal breathing patternsSerious medical problemSubjective daytime alertnessAbnormal breathing eventsAirway pressureRenal failureMedical illnessSleep apneaStokes breathingDaytime alertnessEffective treatmentPatientsSleep respirationBreathing eventsMedical problemsDaytime performanceBreathing
1999
Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position
Bahammam A, Tate R, Manfreda J, Kryger M. Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position. Sleep 1999, 22: 592-598. PMID: 10450594, DOI: 10.1093/sleep/22.5.592.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeStage 1 sleepSleep positionNasal dilationDesaturation timeSleep architectureExternal nasal dilationArousal indexCardiorespiratory parametersSleep stagesNREM sleepNasal cross-sectional areaExternal nasal dilatorSlow-wave sleepObstructive sleepAirway collapsibilityConsecutive patientsNasal dilatorNasal obstructionResistance syndromeSupine positionIntrapharyngeal pressureIndirect markerWave sleepCrossover design
1995
Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders?
Yamashiro Y, Kryger M. Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders? Sleep 1995, 18: 167-171. PMID: 7610312, DOI: 10.1093/sleep/18.3.167.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeExcessive daytime sleepinessHome oximetrySleep disordersSevere OSA patientsTertiary referral hospitalPeriodic limb movementsSleep disorders centerNumber of desaturationsSleep-breathing disordersDisorders of sleepOxygen saturation dataMild OSAOSA patientsPolysomnographic diagnosisReferral hospitalSleep apneaResistance syndromeDaytime sleepinessDisorders CenterBlinded comparisonClinical diagnosisOximetryPolysomnographyPatients
1992
The Effect of Short-term Nasal CPAP on Cheyne-Stokes Respiration in Congestive Heart Failure
Buckle P, Millar T, Kryger M. The Effect of Short-term Nasal CPAP on Cheyne-Stokes Respiration in Congestive Heart Failure. CHEST Journal 1992, 102: 31-35. PMID: 1623779, DOI: 10.1378/chest.102.1.31.Peer-Reviewed Original ResearchConceptsCongestive heart failureCheyne-Stokes respirationMultiple sleep latency testNasal CPAPSleep qualityNocturnal oxygenationHeart failureTreatment nightsDaytime arterial blood gas valuesArterial blood gas valuesNasal CPAP therapyNYHA class 3Sleep latency testBlood gas valuesShort-term treatmentSignificant differencesAge 54.1CPAP therapyMale patientsFull polysomnographyDaytime sleepinessLatency testCPAPPatientsGas valuesPolysomnography in Acutely III Intensive Care Unit Patients
Buckle P, Pouliot Z, Millar T, Kerr P, Kryger M. Polysomnography in Acutely III Intensive Care Unit Patients. CHEST Journal 1992, 102: 288-291. PMID: 1623769, DOI: 10.1378/chest.102.1.288.Peer-Reviewed Original ResearchConceptsCase reportDescriptive studyDouble-blind clinical trialIntensive care unit patientsStudy designCare unit patientsSeries of patientsCase report studySeries of casesUnit patientsCause of diseaseInvestigational protocolsClinical trialsClinical relevanceClinical researchReport studyChestGold standardPatientsReportPolysomnographyTherapyStudyThe importance of nasal resistance in obstructive sleep apnea syndrome.
Kerr P, Millar T, Buckle P, Kryger M. The importance of nasal resistance in obstructive sleep apnea syndrome. Journal Of Otolaryngology 1992, 21: 189-95. PMID: 1404570.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeUpper airway collapseSleep apnea syndromeNasal resistanceOSAS patientsApnea syndromeAirway collapseAmount of apneaArousals/hourChronic nasal obstructionNasal airflow resistanceBaseline data collectionNocturnal oxygenationOSAS populationTopical vasoconstrictorOSAS severityNasal obstructionClinical evidenceNocturnal polysomnographyPSG studiesSubjective improvementPosterior rhinomanometryElevated nasal resistanceConditions of baselineSleep architecture
1991
Effect of Theophylline on Lung Function Tests, Sleep Quality, and Nighttime SaO2 in Children with Cystic Fibrosis
Avital A, Sanchez I, Holbrow J, Kryger M, Chernick V. Effect of Theophylline on Lung Function Tests, Sleep Quality, and Nighttime SaO2 in Children with Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 1991, 144: 1245-1249. PMID: 1741534, DOI: 10.1164/ajrccm/144.6.1245.Peer-Reviewed Original ResearchConceptsEffect of theophyllineCystic fibrosisMicrograms/Heart rateGroup 2Better baseline lung functionT blood levelsBaseline lung functionIncidence of apneaLung function testsSerum T levelsLower heart rateTotal wake timePulmonary functionLung functionSerum levelsFunction testsMean SaO2Blood levelsSleep qualitySleep efficiencyGroup 1Sleep laboratoryT levelsWake timeCentral sleep apnoea in congenital muscular dystrophy.
Kryger M, Steljes D, Yee W, Mate E, Smith S, Mahowald M. Central sleep apnoea in congenital muscular dystrophy. Journal Of Neurology Neurosurgery & Psychiatry 1991, 54: 710. PMID: 1940943, PMCID: PMC1014476, DOI: 10.1136/jnnp.54.8.710.Peer-Reviewed Original ResearchConceptsCentral sleep apnoeaSleep-disordered breathingCongenital muscular dystrophyMorning headachesSleep apnoeaNocturnal seizuresCongestive heart failureMuscular dystrophyPulmonary hypertensionClinical weaknessHeart failureExcessive daytimeNeuromuscular syndromeRespiratory dysfunctionNeuromuscular disordersApnoeaHeadacheSeizuresSymptomsBreathingDystrophyHypertensionDysfunctionSyndrome
1990
Cheyne-Stokes respiration in cardiac failure.
Kryger M, Hanly P. Cheyne-Stokes respiration in cardiac failure. Progress In Clinical And Biological Research 1990, 345: 215-24; discussion 224-6. PMID: 2377634.Peer-Reviewed Original Research
1989
Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea
Hanly P, George C, Millar T, Kryger M. Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea. CHEST Journal 1989, 95: 735-739. PMID: 2924602, DOI: 10.1378/chest.95.4.735.Peer-Reviewed Original ResearchConceptsVoluntary respiratory maneuversObstructive sleep apneaHR responseSleep apneaRespiratory maneuversMueller maneuverOxygen saturationVagal toneAbsence of hypoxemiaArterial oxygen saturationHeart rate responseObstructive apneaMouth pressureApneaHR changesMale subjectsRate responseBreath holdSimilar durationValsalvaSignificant differencesSignificant correlationOSASMajor determinantWakefulness
1988
Identification and Quantification of Apneas by Computer-based Analysis of Oxygen Saturation
George C, Millar T, Kryger M. Identification and Quantification of Apneas by Computer-based Analysis of Oxygen Saturation. American Journal Of Respiratory And Critical Care Medicine 1988, 137: 1238-1240. PMID: 3195821, DOI: 10.1164/ajrccm/137.5.1238.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexApnea-hypopnea eventsNight polysomnogramsObstructive sleep apneaSleep apneaOvernight studyOxygen saturationSaO2 changesPredictive valueFalse negative rateApneaApnea eventsPolysomnogramSaO2 dataMethod of detectionOverall numberDurationNegative rateTotal numberManual scoringSaO2Patients
1987
The Effect of Excessive Ethanol Ingestion on Sleep in Severe Chronic Obstructive Pulmonary Disease
Easton P, West P, Meatherall R, Brewster J, Lertzman M, Kryger M. The Effect of Excessive Ethanol Ingestion on Sleep in Severe Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 224-233. PMID: 3629084, DOI: 10.1093/sleep/10.3.224.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseSevere chronic obstructive pulmonary diseaseObstructive pulmonary diseaseSleep timePulmonary diseaseHeart rateEmphysematous chronic obstructive pulmonary diseaseExcessive ethanol ingestionSignificant O2 desaturationArterial oxygen saturationIngestion of alcoholDose of ethanolSleep stagesExcessive alcohol ingestionTotal sleep timeMean heart ratePremature ventricular contractionsCOPD altersAlcohol ingestionO2 desaturationEthanol ingestionOxygen saturationVentricular contractionsREM timeSerum ethanolSnoring in Normal Young Adults: Prevalence in Sleep Stages and Associated Changes in Oxygen Saturation, Heart Rate, and Breathing Pattern
Perez-Padilla J, West P, Kryger M. Snoring in Normal Young Adults: Prevalence in Sleep Stages and Associated Changes in Oxygen Saturation, Heart Rate, and Breathing Pattern. Sleep 1987, 10: 249-253. PMID: 3629087, DOI: 10.1093/sleep/10.3.249.Peer-Reviewed Original ResearchConceptsHeart rateContinuous snoringSleep stagesOxygen saturationPrevalence of snoringSignificant O2 desaturationMean heart rateNormal young adultsMean SaO2O2 desaturationDifferent pathogenesisDifferent sleep stagesNormal subjectsBreathing patternLight snorersBreathing frequencySnoringArrhythmiasYoung adultsPrevalenceStage 3Same sleep stageStage 2Associated ChangesSubjectsDynamic in Vivo Response Characteristics of Three Oximeters: Hewlett-Packard 47201A, Biox III, and Nellcor N-100
West P, George C, Kryger M. Dynamic in Vivo Response Characteristics of Three Oximeters: Hewlett-Packard 47201A, Biox III, and Nellcor N-100. Sleep 1987, 10: 263-271. PMID: 3629089, DOI: 10.1093/sleep/10.3.263.Peer-Reviewed Original ResearchConceptsOxygen saturation measurementsHeart rateSaO2 measurementsOxygen saturationSleep apnea syndrome patientsArterial oxygen saturationPulse oximeterHewlett-Packard 47201ASyndrome patientsLinear regression analysisSaturation measurementsNellcor NOximeter sensorBiox IIIOximeterPatientsRegression analysisResponse relationshipSleepPulse oximeter sensorSaO2Oxygenation and Breathing Pattern During Phasic and Tonic REM in Patients with Chronic Obstructive Pulmonary Disease
George C, West P, Kryger M. Oxygenation and Breathing Pattern During Phasic and Tonic REM in Patients with Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 234-243. PMID: 3629085, DOI: 10.1093/sleep/10.3.234.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseTonic REMPhasic REMBreathing patternOxygen desaturationPulmonary diseaseSevere chronic obstructive pulmonary diseaseBreathing pattern changesAwake SaO2Nadir SaO2Total REMRespiratory neuronsMore desaturationMotor neuronsOxygen saturationREM sleepSaO2SaO2 differenceTransient decreaseRespiratory amplitudeNight studiesSleepDesaturationPatientsHypercapnia and Sleep O2 Desaturation in Chronic Obstructive Pulmonary Disease
Kryger M, Rogelio P, Conway W, Roth T, Anthonisen N, George C. Hypercapnia and Sleep O2 Desaturation in Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 216-223. PMID: 3629083, DOI: 10.1093/sleep/10.3.216.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseBlue bloatersPink puffersSleep hypoxemiaPulmonary diseaseO2 desaturationHypoxemic chronic obstructive pulmonary diseaseNocturnal Oxygen Therapy TrialBetter lung functionArterial blood gasesWide clinical spectrumHypercapnic patientsSame PaO2Sleep oxygenationSleep SaO2Airflow obstructionHypoxemic patientsPulmonary hypertensionCOPD populationHypercapnic groupMost patientsNormocapnic patientsLung functionBlood gasesPerfluorochemical Artificial Blood as a Volume Expander in Hypoxemic Respiratory Failure in Dogs
Light R, Perez-Padilla R, Kryger M. Perfluorochemical Artificial Blood as a Volume Expander in Hypoxemic Respiratory Failure in Dogs. CHEST Journal 1987, 91: 444-449. PMID: 3816321, DOI: 10.1378/chest.91.3.444.Peer-Reviewed Original ResearchConceptsAdult respiratory distress syndromeArteriovenous O2 content differenceHypoxemic respiratory failureArterial O2 contentO2 content differenceVolume expandersRespiratory failureIntrapulmonary shuntPFC groupFluosol-DARespiratory distress syndromeSystemic vascular pressuresArterial O2 tensionEffective volume expanderTissue O2 deliveryOriginal disorderDistress syndromeCentral hemodynamicsPulmonary edemaCardiac outputContent differenceBlood productsVascular pressuresO2 deliveryPerfluorochemical artificial blood
1986
Breathing during Sleep in Normal Pregnant Women1–3
Brownell L, West P, Kryger M. Breathing during Sleep in Normal Pregnant Women1–3. American Journal Of Respiratory And Critical Care Medicine 1986, 133: 38-41. PMID: 3942378, DOI: 10.1164/arrd.1986.133.1.38.Peer-Reviewed Original ResearchConceptsLate pregnancyMinimal arterial oxygen saturationMaternal oxygen desaturationFrequency of apneaRespiratory sleep studiesAlveolar-arterial differenceArterial oxygen saturationFunctional residual capacityLevels of progesteroneSleep-related apneaTotal apneaOxygen desaturationMaternal oxygenationComplete polysomnographyWk gestationPregnant womenCardiac outputLast trimesterPhysiologic changesResidual volumeSupine positionSleep studiesOxygen saturationPregnancyApnea
1985
Sleep in Restrictive Lung Disorders
Kryger M. Sleep in Restrictive Lung Disorders. Clinics In Chest Medicine 1985, 6: 675-677. PMID: 3853479, DOI: 10.1016/s0272-5231(21)00404-4.Peer-Reviewed Original Research