2020
Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome
Sakellariou D, Nesbitt AD, Higgins S, Beniczky S, Rosenzweig J, Drakatos P, Gildeh N, Murphy PB, Kent B, Williams AJ, Kryger M, Goadsby PJ, Leschziner GD, Rosenzweig I. Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome. Cephalalgia 2020, 40: 949-958. PMID: 32276548, PMCID: PMC7412948, DOI: 10.1177/0333102420902705.Peer-Reviewed Original ResearchConceptsHead syndromeRetrospective case-control studyPotential underlying pathophysiologyWhole-night EEGsSleep/wake periodsSleep disorders clinicCase-control studyWake-sleep statesExternal sensory stimuliElectroencephalographic biomarkerPatients' qualityUnderlying pathophysiologyDisorders ClinicSleep-wake transitionsPolysomnographic recordingsSyndromeAlpha-band oscillationsPatientsOscillatory activityWake periodAlpha rhythmSensory stimuliBand oscillationsLoud noisePreliminary findings
2019
Centers for Medicare and Medicaid Services Positive Airway Pressure Adherence Criteria May Limit Treatment to Many Medicare Beneficiaries.
Naik S, Al-Halawani M, Kreinin I, Kryger M. Centers for Medicare and Medicaid Services Positive Airway Pressure Adherence Criteria May Limit Treatment to Many Medicare Beneficiaries. Journal Of Clinical Sleep Medicine 2019, 15: 245-251. PMID: 30736874, PMCID: PMC6374085, DOI: 10.5664/jcsm.7626.Peer-Reviewed Original ResearchConceptsEvents/hAdherence criteriaPAP treatmentObstructive sleep apnea treatmentPositive airway pressure devicesWithholding of therapyApnea-hypopnea indexObstructive sleep apneaSleep apnea treatmentMedicaid Services reimbursementAdherence reportsBaseline characteristicsPAP devicesPAP adherenceAdherent participantsApnea treatmentSleep apneaNonadherent participantsAdherence dataMedicare beneficiariesAdherence patternsCMS criteriaAdherence expectationsPatientsMonths
2018
Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography
Johnson KG, Johnson DC, Thomas RJ, Feldmann E, Lindenauer PK, Visintainer P, Kryger MH. Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography. Sleep Medicine 2018, 67: 249-255. PMID: 30583916, PMCID: PMC6548700, DOI: 10.1016/j.sleep.2018.11.014.Peer-Reviewed Original ResearchConceptsApnea/hypopnea indexObstructive sleep apneaMild obstructive sleep apneaSleep apneaAirflow disruptionIntraclass correlationAHI categoriesBaseline PSGHypopnea indexOSA patientsHighest tertileOSA categoriesArousal criteriaPatientsFlow limitationApneaDesaturationFlow scoreArousal eventsOverall kappaObstructionTraining periodHigher proportionElectroencephalographyScoringWomen's Sleep Across the Reproductive Life Span.
Tobias L, Kryger M. Women's Sleep Across the Reproductive Life Span. Journal Of Clinical Sleep Medicine 2018, 14: 1095-1096. PMID: 29991440, PMCID: PMC6040808, DOI: 10.5664/jcsm.7200.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2016
Sleep: a refuge from danger
Siegel I, Kryger MH. Sleep: a refuge from danger. Sleep Health 2016, 2: 263. PMID: 29073386, DOI: 10.1016/j.sleh.2016.08.005.Commentaries, Editorials and LettersThe Enigma of the Sleeping Girl
Siegel I, Kryger MH. The Enigma of the Sleeping Girl. Sleep Health 2016, 2: 85. PMID: 28923263, DOI: 10.1016/j.sleh.2016.02.002.Commentaries, Editorials and LettersEffects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea.
Sun H, Palcza J, Card D, Gipson A, Rosenberg R, Kryger M, Lines C, Wagner JA, Troyer MD. Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea. Journal Of Clinical Sleep Medicine 2016, 12: 9-17. PMID: 26194728, PMCID: PMC4702197, DOI: 10.5664/jcsm.5382.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaOrexin receptor antagonistMean AHIRespiratory effectsSleep apneaMultiple dosesReceptor antagonistIntra-individual variabilityModerate obstructive sleep apneaEffects of suvorexantLowest effective doseSleep laboratory studiesTotal sleep timeMean SpO2Single doseRespiratory functionOxygen saturationPulse oximetryPlaceboPatientsSleep timeAHIDay 4Mean increaseSuvorexant
2015
The Use of a Fully Automated Automatic Adaptive Servoventilation Algorithm in the Acute and Long-term Treatment of Central Sleep Apnea
Javaheri S, Winslow D, McCullough P, Wylie P, Kryger MH. The Use of a Fully Automated Automatic Adaptive Servoventilation Algorithm in the Acute and Long-term Treatment of Central Sleep Apnea. CHEST Journal 2015, 148: 1454-1461. PMID: 25950507, DOI: 10.1378/chest.14-2966.Peer-Reviewed Original ResearchConceptsCentral apnea indexApnea-hypopnea indexCentral sleep apneaSleep apneaSleep qualityComplex sleep-disordered breathingASV deviceASV titrationAdaptive servoventilation devicesCongestive heart failureMonths of treatmentSleep-disordered breathingEpworth Sleepiness ScaleLong-term treatmentImproved sleep qualityMixed sleep apneaBetter sleep qualityApnea indexHeart failureObservational trialObstructive apneaBreathing disordersInspiratory pressureArousal indexDaytime sleepinessIn Reply
Mutter TC, Chateau D, Moffatt M, Ramsey C, Roos LL, Kryger M. In Reply. Anesthesiology 2015, 123: 230-231. PMID: 26510197, DOI: 10.1097/aln.0000000000000684.Commentaries, Editorials and LettersEffects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease
Sun H, Palcza J, Rosenberg R, Kryger M, Siringhaus T, Rowe J, Lines C, Wagner JA, Troyer MD. Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease. Respiratory Medicine 2015, 109: 416-426. PMID: 25661282, DOI: 10.1016/j.rmed.2014.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAzepinesCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle AgedOrexin Receptor AntagonistsPulmonary Disease, Chronic ObstructiveRespirationSeverity of Illness IndexSleepSleep Aids, PharmaceuticalSpirometryTreatment OutcomeTriazolesUnited StatesConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseSleep breathing disordersOrexin receptor antagonistPulmonary diseaseBreathing disordersReceptor antagonistModerate chronic obstructive pulmonary diseaseDay 4Effects of suvorexantModerate airflow limitationRespiratory depressant effectsApnea-hypopnea indexMaximum daily doseClinical research unitTotal sleep timeTreatment of insomniaMean AHICOPD patientsAirflow limitationHypopnea indexDaily doseMean SpO2Spirometry criteriaHypnotic medications
2014
A Matched Cohort Study of Postoperative Outcomes in Obstructive Sleep Apnea
Mutter TC, Chateau D, Moffatt M, Ramsey C, Roos LL, Kryger M. A Matched Cohort Study of Postoperative Outcomes in Obstructive Sleep Apnea. Anesthesiology 2014, 121: 707-718. PMID: 25247853, DOI: 10.1097/aln.0000000000000407.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressure therapyPositive airway pressure therapyObstructive sleep apneaAirway pressure therapySleep apneaPressure therapyOSA patientsCardiovascular complicationsPostoperative outcomesDiagnosis of OSAUndiagnosed obstructive sleep apneaAdult OSA patientsImportant risk modifiersPostoperative cardiovascular complicationsMatched Cohort StudyHealth administrative dataType of surgeryLarger efficacy trialPostoperative complicationsRespiratory complicationsCohort studyOSA severityPostoperative dayPreoperative diagnosisCardiac arrestEvaluation of a new pediatric positive airway pressure mask.
Kushida CA, Halbower AC, Kryger MH, Pelayo R, Assalone V, Cardell CY, Huston S, Willes L, Wimms AJ, Mendoza J. Evaluation of a new pediatric positive airway pressure mask. Journal Of Clinical Sleep Medicine 2014, 10: 979-84. PMID: 25142768, PMCID: PMC4153116, DOI: 10.5664/jcsm.4030.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePAP therapyPositive airway pressure maskPositive airway pressureParents/guardiansAirway pressureBaseline polysomnographyCPAP maskChildren's earsPressure maskPatientsAge groupsChildren's sleepUpper lipPolysomnographyChildrenTherapySleepEarYearsAHIClinicClinicians
2013
The use of combined thermal/pressure polyvinylidene fluoride film airflow sensor in polysomnography
Kryger M, Eiken T, Qin L. The use of combined thermal/pressure polyvinylidene fluoride film airflow sensor in polysomnography. Sleep And Breathing 2013, 17: 1267-1273. PMID: 23716021, DOI: 10.1007/s11325-013-0832-5.Peer-Reviewed Original Research
2012
Charles Dickens: impact on medicine and society.
Kryger M. Charles Dickens: impact on medicine and society. Journal Of Clinical Sleep Medicine 2012, 8: 333-8. PMID: 22701393, PMCID: PMC3365094, DOI: 10.5664/jcsm.1930.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRespiratory Event Detection by a Positive Airway Pressure Device
Berry RB, Kushida CA, Kryger MH, Soto-Calderon H, Staley B, Kuna ST. Respiratory Event Detection by a Positive Airway Pressure Device. Sleep 2012, 35: 361-367. PMID: 22379242, PMCID: PMC3274337, DOI: 10.5665/sleep.1696.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaEvents/hrPositive airway pressure devicesApnea indexHypopnea indexPAP devicesRespiratory eventsSleep disorders centerPressure deviceBetter treatment efficacyRespiratory event detectionOxygen desaturationSleep apneaPAP treatmentBland-Altman analysisDisorders CenterPolysomnographyTreatment efficacyAHIInadequate treatmentManual scoringHypopnea detectionTrue negative eventsHrTreatment
2011
Is Laryngeal Descent Associated With Increased Risk for Obstructive Sleep Apnea?
Yamashiro Y, Kryger M. Is Laryngeal Descent Associated With Increased Risk for Obstructive Sleep Apnea? CHEST Journal 2011, 141: 1407-1413. PMID: 22016482, DOI: 10.1378/chest.10-3238.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaAirway lengthSleep apneaJapanese patientsVocal cordsUpper airway lengthLogistic regression analysisMultislice CT scanOSA severityConsecutive patientsUpper airwayRisk factorsCT scanBMIPatientsALVCAHILow laryngeal positionLaryngeal positionCollapsible segmentApneaRegression analysisCordLarynxWomenLong-term use of a nasal expiratory positive airway pressure (EPAP) device as a treatment for obstructive sleep apnea (OSA).
Kryger MH, Berry RB, Massie CA. Long-term use of a nasal expiratory positive airway pressure (EPAP) device as a treatment for obstructive sleep apnea (OSA). Journal Of Clinical Sleep Medicine 2011, 7: 449-53b. PMID: 22003339, PMCID: PMC3190843, DOI: 10.5664/jcsm.1304.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaPositive airway pressure devicesMonths of treatmentSleep apneaObstructive sleep apnea hypopneaOpen-label extensionPositive clinical responseEvents/hLong-term adherenceSleep disorders centerEpworth Sleepiness ScaleSleep apnea hypopneaPressure deviceLong-term useAHI reductionClinical responseMonth 3Randomized studyApnea hypopneaMedian AHITrial nameClinical trialsMonths 1Disorders CenterSham trialsPositive Airway Pressure Initiation: A Randomized Controlled Trial to Assess the Impact of Therapy Mode and Titration Process on Efficacy, Adherence, and Outcomes
Kushida CA, Berry RB, Blau A, Crabtree T, Fietze I, Kryger MH, Kuna ST, Pegram GV, Penzel T. Positive Airway Pressure Initiation: A Randomized Controlled Trial to Assess the Impact of Therapy Mode and Titration Process on Efficacy, Adherence, and Outcomes. Sleep 2011, 34: 1083-1092. PMID: 21804670, PMCID: PMC3138163, DOI: 10.5665/sleep.1166.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureMinimum oxygen saturationAirway pressureFunctional outcomeOxygen saturationVeterans Affairs Medical CenterPositive pressure treatmentApnea-hypopnea indexObstructive sleep apneaSevere OSAMulticenter trialTreatment satisfactionControlled TrialsSleep apneaMajor efficacyStudy treatmentOutcome measuresMedical CenterSleep qualityTherapy modesMask comfortAdherenceEfficacyMonthsA Novel Nasal Expiratory Positive Airway Pressure (EPAP) Device for the Treatment of Obstructive Sleep Apnea: A Randomized Controlled Trial
Berry RB, Kryger MH, Massie CA. A Novel Nasal Expiratory Positive Airway Pressure (EPAP) Device for the Treatment of Obstructive Sleep Apnea: A Randomized Controlled Trial. Sleep 2011, 34: 479-485. PMID: 21461326, PMCID: PMC3065258, DOI: 10.1093/sleep/34.4.479.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaPositive airway pressure devicesSleep apneaSham deviceWeek 1Double-blind clinical trialSevere obstructive sleep apneaMonths of treatmentSleep disorders centerEpworth Sleepiness ScalePressure deviceSubjective daytime sleepinessNon-consecutive nightsControlled TrialsMonth 3Sham treatmentClinical trialsDaytime sleepinessITT groupDisorders CenterSleepiness ScaleAHI valuesApneaMedian percentageAHI
2010
Prediction of obstructive sleep apnea syndrome in a large Greek population
Bouloukaki I, Kapsimalis F, Mermigkis C, Kryger M, Tzanakis N, Panagou P, Moniaki V, Vlachaki EM, Varouchakis G, Siafakas NM, Schiza SE. Prediction of obstructive sleep apnea syndrome in a large Greek population. Sleep And Breathing 2010, 15: 657-664. PMID: 20872180, DOI: 10.1007/s11325-010-0416-6.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeApnea-hypopnea indexBody mass indexSleep apnea syndromeApnea syndromeSignificant clinical predictorsInitiation of treatmentLogistic regression analysisSelf-reported symptomsEDS severityNinety patientsSleepiness severityClinical predictorsIndependent predictorsPSG evaluationMass indexDiagnostic polysomnographyHip circumferenceClinical indicesScore 10High riskAnthropometric measurementsScore 4Predictive valuePatients