1999
Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position
Bahammam A, Tate R, Manfreda J, Kryger M. Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position. Sleep 1999, 22: 592-598. PMID: 10450594, DOI: 10.1093/sleep/22.5.592.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeStage 1 sleepSleep positionNasal dilationDesaturation timeSleep architectureExternal nasal dilationArousal indexCardiorespiratory parametersSleep stagesNREM sleepNasal cross-sectional areaExternal nasal dilatorSlow-wave sleepObstructive sleepAirway collapsibilityConsecutive patientsNasal dilatorNasal obstructionResistance syndromeSupine positionIntrapharyngeal pressureIndirect markerWave sleepCrossover design
1998
Effect of Pergolide on Restless Legs and Leg Movements in Sleep in Uremic Patients
Pieta J, Miliar T, Zacharias J, Fine A, Kryger M. Effect of Pergolide on Restless Legs and Leg Movements in Sleep in Uremic Patients. Sleep 1998, 21: 617-622. PMID: 9779521, DOI: 10.1093/sleep/21.6.617.Peer-Reviewed Original ResearchConceptsRestless legs syndromeLeg movementsRestless legsUremic patientsSubjective improvementTreatment of RLSDouble-blind placebo-controlled crossover studyPlacebo-controlled crossover studyRestless legs symptomsEffects of pergolideContinuous peritoneal dialysisPeriodic limb movementsSmall patient groupsHours of sleepQuality of sleepFirst hourChronic hemodialysisLeg symptomsCrossover studyLegs syndromePeritoneal dialysisIncremental dosesPatient groupSleep architectureSleep disruption
1993
Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration
Biberdorf D, Steens R, Millar T, Kryger M. Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration. Sleep 1993, 16: 529-538. PMID: 8235237, DOI: 10.1093/sleep/16.6.529.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureTotal sleep timePercentage of TSTApnea/hypopnea indexOxygen saturationTotal wake timeEffects of temazepamHeart failureSleep architectureDouble-blind crossover trialSevere congestive heart failureOvernight oxygen saturationStage 1 sleepHours of sleepSleep stage proportionsCHF patientsHypopnea indexMale patientsDaytime somnolenceCrossover trialSignificant changesFrequent arousalsDaytime alertnessSleep timeSleep in nondepressed patients with panic disorder: II. Polysomnographic assessment of sleep architecture and sleep continuity
Stein M, Enns M, Kryger M. Sleep in nondepressed patients with panic disorder: II. Polysomnographic assessment of sleep architecture and sleep continuity. Journal Of Affective Disorders 1993, 28: 1-6. PMID: 8326076, DOI: 10.1016/0165-0327(93)90071-q.Peer-Reviewed Original ResearchConceptsPanic disorderAge-comparable healthy controlsNon-depressed patientsTotal sleep timeNondepressed patientsPolysomnographic assessmentDepressed patientsHealthy controlsMajor depressionSleep architectureSleep continuitySleep maintenanceDelta sleepEEG sleepPatientsNormal sleepSleep timeSleepDisordersModest reductionImpairment
1992
The importance of nasal resistance in obstructive sleep apnea syndrome.
Kerr P, Millar T, Buckle P, Kryger M. The importance of nasal resistance in obstructive sleep apnea syndrome. Journal Of Otolaryngology 1992, 21: 189-95. PMID: 1404570.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeUpper airway collapseSleep apnea syndromeNasal resistanceOSAS patientsApnea syndromeAirway collapseAmount of apneaArousals/hourChronic nasal obstructionNasal airflow resistanceBaseline data collectionNocturnal oxygenationOSAS populationTopical vasoconstrictorOSAS severityNasal obstructionClinical evidenceNocturnal polysomnographyPSG studiesSubjective improvementPosterior rhinomanometryElevated nasal resistanceConditions of baselineSleep architecture
1986
Sleep in Restrictive Lung Disease
George C, Kryger M. Sleep in Restrictive Lung Disease. Sleep 1986, 10: 409-418. PMID: 3317724, DOI: 10.1093/sleep/10.5.409.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseLung diseaseNocturnal oxygenNocturnal desaturationMuscle weaknessLung disease patientsRestrictive lung diseaseFibrotic lung diseaseUse of drugsFurther hypoxemiaNocturnal hypoxemiaNasal CPAPNocturnal hypoventilationAcute alveolitisLong-term evaluationRestrictive diseaseOxygenation abnormalitiesDisease patientsKyphoscoliosis patientsDeformity changesSleep changesSleep architectureSleep structureNeuromuscular diseasePatients