2016
Positive Airway Pressure Therapy for Obstructive Sleep Apnea
Weiss P, Kryger M. Positive Airway Pressure Therapy for Obstructive Sleep Apnea. Otolaryngologic Clinics Of North America 2016, 49: 1331-1341. PMID: 27720457, DOI: 10.1016/j.otc.2016.07.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPositive airway pressureObstructive sleep apneaAirway pressureSleep apneaMild obstructive sleep apneaPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaObstructive sleep apnea syndromeSleep-related breathing disordersConcomitant cardiovascular disordersAirway pressure therapyFirst-line therapySleep apnea syndromeAdaptive support ventilationEvaluation of adherenceEffectiveness of treatmentApnea syndromeSupport ventilationBreathing disordersPressure therapyCardiovascular disordersApneaTherapyPressure support
2015
Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome
Knauert M, Naik S, Gillespie MB, Kryger M. Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome. World Journal Of Otorhinolaryngology - Head And Neck Surgery 2015, 1: 17-27. PMID: 29204536, PMCID: PMC5698527, DOI: 10.1016/j.wjorl.2015.08.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsObstructive sleep apnea syndromeSleep apnea syndromeUntreated obstructive sleep apnea syndromeApnea syndromeEffective therapyPoor patient acceptanceStart date restrictionLack of diagnosisSignificant economic burdenEnglish-language studiesExcessive daytimeSleep apneaPatient acceptanceCardiovascular diseaseClinical consequencesDate restrictionsEconomic burdenMetabolic diseasesPubMed databaseAbnormal physiologySyndromeTherapyLack of accessDiseaseTreatment
2010
Prediction of obstructive sleep apnea syndrome in a large Greek population
Bouloukaki I, Kapsimalis F, Mermigkis C, Kryger M, Tzanakis N, Panagou P, Moniaki V, Vlachaki EM, Varouchakis G, Siafakas NM, Schiza SE. Prediction of obstructive sleep apnea syndrome in a large Greek population. Sleep And Breathing 2010, 15: 657-664. PMID: 20872180, DOI: 10.1007/s11325-010-0416-6.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeApnea-hypopnea indexBody mass indexSleep apnea syndromeApnea syndromeSignificant clinical predictorsInitiation of treatmentLogistic regression analysisSelf-reported symptomsEDS severityNinety patientsSleepiness severityClinical predictorsIndependent predictorsPSG evaluationMass indexDiagnostic polysomnographyHip circumferenceClinical indicesScore 10High riskAnthropometric measurementsScore 4Predictive valuePatients
2009
Sleep Breathing Disorders in the U.S. Female Population
Kapsimalis F, Kryger M. Sleep Breathing Disorders in the U.S. Female Population. Journal Of Women's Health 2009, 18: 1211-1219. PMID: 19627224, PMCID: PMC2825714, DOI: 10.1089/jwh.2008.1054.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeU.S. female populationHigh riskBerlin questionnaireFemale populationCommon symptomsDaytime sleepinessMedical disordersPrimary care medical communityRestless legs syndrome symptomsChronic medical disordersSleep apnea syndromeSleep breathing disordersMenstrual cycle statusSleep onset insomniaSuch common symptomsNational Sleep FoundationAnnual telephone surveyHabitual snoringApnea syndromeBreathing disordersPostpartum womenCommon disorderSyndrome symptomsOnset insomnia
2008
Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea
Kapsimalis F, Varouchakis G, Manousaki A, Daskas S, Nikita D, Kryger M, Gourgoulianis K. Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea. Lung 2008, 186: 209-217. PMID: 18365276, DOI: 10.1007/s00408-008-9082-x.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea severityObstructive sleep apneaNon-OSA groupBody mass indexModerate OSAS groupCRP levelsInsulin resistanceApnea severityOSAS groupMale patientsLeptin levelsSleep apneaSevere obstructive sleep apnea syndromeHomeostasis model assessment methodSevere sleep apneaSevere OSAS groupSleep apnea syndromeC-reactive proteinTotal sleep timeNocturnal hypoxemiaApnea syndromeModel assessment methodHip ratioMass index
2007
Obstructive Sleep Apnea in Pregnancy
Kapsimalis F, Kryger M. Obstructive Sleep Apnea in Pregnancy. Sleep Medicine Clinics 2007, 2: 603-613. DOI: 10.1016/j.jsmc.2007.07.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsObstructive sleep apnea syndromeSleep-disordered breathingPregnant womenTreatment of OSASDiagnosis of OSASTreatment of SDBObese pregnant womenComplications of pregnancyOutcome of pregnancyObstructive sleep apneaSleep apnea syndromeManagement of pregnancyApnea syndromeSleep apneaHormonal alterationsFetal healthEarly recognitionHigh indexPregnancyNormal sleepRespiratory systemWomenTreatmentHypertensionApneaSleep apnea: Clinical investigations in humans
Banno K, Kryger MH. Sleep apnea: Clinical investigations in humans. Sleep Medicine 2007, 8: 400-426. PMID: 17478121, DOI: 10.1016/j.sleep.2007.03.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apnea syndromeCentral sleep apnea syndromeContinuous positive airway pressureSleep apnea syndromeApnea syndromeApneic episodesTreatment of OSASDiagnosis of SASUpper airway obstructionPositive airway pressureMuscles of respirationCessation of breathingCentral nervous systemAirway obstructionAirway pressureHeart failureOral appliancesRespiratory driveImpaired qualityAbnormal breathingSubjective symptomsDaytime sleepinessCommon disorderMetabolic dysfunctionSleep disruption
2006
Healthcare Utilization in Women with Obstructive Sleep Apnea Syndrome 2 Years After Diagnosis and Treatment
Banno K, Manfreda J, Walld R, Delaive K, Kryger MH. Healthcare Utilization in Women with Obstructive Sleep Apnea Syndrome 2 Years After Diagnosis and Treatment. Sleep 2006, 29: 1307-1311. PMID: 17068984, DOI: 10.1093/sleep/29.10.1307.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeContinuous positive airway pressureClinic visitsHealthcare utilizationWeight lossTertiary university-based medical centerRetrospective observational cohort studyEntire groupUniversity-based medical centerTreatment-compliant patientsObservational cohort studyPositive airway pressureSleep apnea syndromeAirway pressureCohort studyCompliant patientsApnea syndromePhysician claimsMedical CenterWL groupGeneral populationPatientsDiagnosisVisitsWomenGender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome
Vagiakis E, Kapsimalis F, Lagogianni I, Perraki H, Minaritzoglou A, Alexandropoulou K, Roussos C, Kryger M. Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome. Sleep Medicine 2006, 7: 424-430. PMID: 16740405, DOI: 10.1016/j.sleep.2005.12.014.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeApnea-hypopnea indexBody mass indexSleep apnea syndromeMale patientsApnea syndromeFemale patientsOnset latencyMean apnea-hypopnea indexSleep apnea hypopnea indexHigher apnea-hypopnea indexNon-rapid eye movement sleepSleep disorders centerREM onset latencyEye movement sleepAthens Medical SchoolPercent of menSleep efficiency indexTotal sleep timeGreek subjectsAspects of sleepSleep onset latencyNorth American clinicsEvangelismos HospitalNREM-AHI
2005
Sleep disorders in older people
Banno K, Kryger M. Sleep disorders in older people. Aging Health 2005, 1: 449-457. DOI: 10.2217/1745509x.1.3.449.Peer-Reviewed Original ResearchSleep disordersObstructive sleep apnea syndromeOlder peopleAge-related medical conditionsSleep apnea syndromeRestless legs syndromeFrequent nocturnal awakeningsCommon sleep disorderQuality of lifeSleep onset insomniaObstructive sleepApnea syndromeNeuropsychiatric functionRestless legsLegs syndromeImpaired qualityNocturnal awakeningsUpper airwayAnatomic changesCognitive dysfunctionMedical conditionsSleep pathologyPsychiatric conditionsNeuropsychiatric disordersPatient healthUtilization of Healthcare Resources in Obstructive Sleep Apnea Syndrome: a 5Year Follow-Up Study in Men Using CPAP
Albarrak M, Banno K, Al. Sabbagh AA, Delaive K, Walld R, Manfreda J, Kryger MH. Utilization of Healthcare Resources in Obstructive Sleep Apnea Syndrome: a 5Year Follow-Up Study in Men Using CPAP. Sleep 2005, 28: 1306-1311. PMID: 16295216, DOI: 10.1093/sleep/28.10.1306.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeIschemic heart diseaseHealthcare utilizationApnea syndromeHeart diseaseTreatment of OSASContinuous positive airway pressure useUntreated obstructive sleep apnea syndromeRetrospective observational cohort studyPositive airway pressure useEpworth Sleepiness Scale scoreLong-term health benefitsHigher healthcare utilizationObservational cohort studyApnea-hypopnea indexBody mass indexCPAP treatmentCohort studyPhysician visitsMass indexEligible menOSAS diagnosisFifth yearOSA diagnosisExperience in using split-day studies for suspected obstructive sleep apnea syndrome
Banno K, Al Sabbagh A, Delaive K, Higami S, Kryger MH. Experience in using split-day studies for suspected obstructive sleep apnea syndrome. Respiratory Medicine 2005, 99: 1334-1339. PMID: 16140233, DOI: 10.1016/j.rmed.2005.02.030.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeSleep breathing disordersApnea syndromeInconclusive studiesSevere obstructive sleep apnea syndromeSevere daytime sleepinessEligible casesBreathing disordersDefinitive diagnosisFinal diagnosisDaytime sleepinessMovement disordersSleep disordersSleep studiesPatientsSleep deprivationDiagnosisSubjective sleepinessAdditional assessmentDisordersInsufficient dataSyndromeSleepinessConclusive studiesDifferences between Men and Women in the Clinical Presentation of Patients Diagnosed with Obstructive Sleep Apnea Syndrome
Shepertycky M, Banno K, Kryger MH. Differences between Men and Women in the Clinical Presentation of Patients Diagnosed with Obstructive Sleep Apnea Syndrome. Sleep 2005, 28: 309-314. PMID: 16173651, DOI: 10.1093/sleep/28.3.309.Peer-Reviewed Original ResearchConceptsEpworth Sleepiness Scale scoreApnea-hypopnea indexBody mass indexClinical presentationMass indexObstructive sleep apnea syndrome (OSA) resultsTertiary university-based medical centerScale scoreRetrospective chart review analysisObstructive sleep apnea syndromeUniversity-based medical centerLaboratory polysomnographic studiesMain presenting symptomChart review analysisUpper airway anatomySleep apnea syndromeHistory of depressionGender-related differencesLess alcohol consumptionPolysomnographic findingsPresenting symptomApnea syndromeHypothyroid diseasePolysomnographic studyPrimary complaint
2004
Review article: sleep and its relationship to gastro‐oesophageal reflux
Orr W, Heading R, Johnson L, Kryger M. Review article: sleep and its relationship to gastro‐oesophageal reflux. Alimentary Pharmacology & Therapeutics 2004, 20: 39-46. PMID: 15527463, DOI: 10.1111/j.1365-2036.2004.02239.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastro-oesophageal reflux diseaseReflux eventsObstructive sleep apnea syndromeMost symptomatic patientsGastro-oesophageal refluxSleep apnea syndromeSlow gastric emptyingCommon gastrointestinal conditionsFrequency of swallowingReflux diseaseRespiratory complicationsSymptomatic patientsApnea syndromeGastric emptyingDecreased qualitySaliva productionPatientsSleepGastrointestinal conditionsPhysiological changesClearance behaviorConscious perceptionHeartburnComplicationsObesityReducing Motor-Vehicle Collisions, Costs, and Fatalities by Treating Obstructive Sleep Apnea Syndrome
Sassani A, Findley LJ, Kryger M, Goldlust E, George C, Davidson TM. Reducing Motor-Vehicle Collisions, Costs, and Fatalities by Treating Obstructive Sleep Apnea Syndrome. Sleep 2004, 27: 453-458. PMID: 15164898, DOI: 10.1093/sleep/27.3.453.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeContinuous positive airway pressureMotor vehicle collisionsSleep apnea syndrome
2003
Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity
SHEPERTYCKY M, AL‐BARRAK M, KRYGER M. Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity. Sleep And Biological Rhythms 2003, 1: 15-28. DOI: 10.1046/j.1446-9235.2003.00003.x.Peer-Reviewed Original ResearchObstructive sleep apnea syndromeSevere cardiovascular outcomesCongestive heart failureIschemic heart diseaseCardiovascular morbidityHeart failureCardiovascular outcomesPulmonary hypertensionSystemic hypertensionHeart diseaseCardiac arrhythmiasContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentOngoing population-based studyLarge ongoing trialsUntreated OSAS patientsIndependent risk factorDevelopment of hypertensionEpisodes of apneaSleep apnea syndromePopulation-based studyEffect of treatmentNocturnal hypoxemiaOSA patientsOSAS patients
2002
Gender and Obstructive Sleep Apnea Syndrome, Part 2: Mechanisms
Kapsimalis F, Kryger MH. Gender and Obstructive Sleep Apnea Syndrome, Part 2: Mechanisms. Sleep 2002, 25: 497-504. PMID: 12150315, DOI: 10.1093/sleep/25.5.497.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apnea syndromeSleep apnea syndromeApnea syndromeUpper airway muscle functionHormone replacement therapyUpper airway anatomySleep breathing disordersControl of ventilationOSAS prevalenceBreathing disordersReplacement therapySex hormonesCommon disorderFemale genderMuscle functionEpidemiologic studiesAdipose tissueSyndromeDisordersAdult malesGenderRiskFemalesPercentObesityGender and Obstructive Sleep Apnea Syndrome, Part 1: Clinical Features
Kapsimalis F, Kryger MH. Gender and Obstructive Sleep Apnea Syndrome, Part 1: Clinical Features. Sleep 2002, 25: 409-416. PMID: 12071542, DOI: 10.1093/sleep/25.4.409.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apnea syndromeSleep apnea syndromeApnea syndromeGeneral populationPrevalence of OSASOSAS casesPolysomnography findingsMale predominanceClinical featuresClinical presentationFemale patientsClinic populationEpidemiologic studiesPathophysiologic studiesSyndromeFemalesMalesPopulationLatest studiesPatientsPrevalenceDiseaseStudyOnly malesWomenWhat Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis?
Smith R, Ronald J, Delaive K, Walld R, Manfreda J, Kryger MH. What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis? CHEST Journal 2002, 121: 164-172. PMID: 11796446, DOI: 10.1378/chest.121.1.164.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeBody mass indexChronic obstructive airways diseaseObstructive airways diseaseHealth care utilizationSleep apnea patientsControl subjectsApnea patientsAirway diseaseOSAS patientsCardiovascular diseaseObstructive sleep apnea patientsHealth care utilization measuresApnea-hypopnea indexCongestive heart failureEffect of obesityIschemic heart diseaseSleep apnea syndromeDegree of hypoxemiaSignificant independent predictorsLogistic regression analysisCertain cardiovascular disordersHealth care resourcesRegression analysisApnea syndrome
2000
Diagnosis and management of sleep apnea syndrome
Kryger M. Diagnosis and management of sleep apnea syndrome. Clinical Cornerstone 2000, 2: 39-44. PMID: 10875045, DOI: 10.1016/s1098-3597(00)90039-5.Peer-Reviewed Original ResearchConceptsSleep apnea syndromeApnea syndromeContinuous positive airway pressureMain presenting symptomPositive airway pressureSleep breathing disordersConstellation of signsPresenting symptomAirway pressureMost patientsExcessive daytimeSleep apneaBreathing disordersAbnormal breathingComplete resolutionSleep disruptionBusy cliniciansSymptomsSyndromeSleepDiagnosisDisordersEpisodesHypoxemiaApnea