Effect of Pergolide on Restless Legs and Leg Movements in Sleep in Uremic Patients
Pieta J, Miliar T, Zacharias J, Fine A, Kryger M. Effect of Pergolide on Restless Legs and Leg Movements in Sleep in Uremic Patients. Sleep 1998, 21: 617-622. PMID: 9779521, DOI: 10.1093/sleep/21.6.617.Peer-Reviewed Original ResearchConceptsRestless legs syndromeLeg movementsRestless legsUremic patientsSubjective improvementTreatment of RLSDouble-blind placebo-controlled crossover studyPlacebo-controlled crossover studyRestless legs symptomsEffects of pergolideContinuous peritoneal dialysisPeriodic limb movementsSmall patient groupsHours of sleepQuality of sleepFirst hourChronic hemodialysisLeg symptomsCrossover studyLegs syndromePeritoneal dialysisIncremental dosesPatient groupSleep architectureSleep disruptionSusceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea
Wali S, Bahammam A, Massaeli H, Pierce G, Iliskovic N, Singal P, Kryger M. Susceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea. Sleep 1998, 21: 290-296. PMID: 9595608, DOI: 10.1093/sleep/21.3.290.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinObstructive sleep apneaOSA patientsNormal controlsOxidative stressSleep apneaPatient groupSevere hypoxiaSusceptibility of LDLFree radical challengeSame age groupCPAP therapySevere hypoxemiaRed blood cellsCardiovascular diseaseAntioxidant reserveGeneral populationPatientsIndividual low-density lipoproteinHours of exposureControl groupAge groupsGlutathione peroxidaseBlood cellsConjugated dienes