2008
Assessment and Management of Patients with Obesity Hypoventilation Syndrome
Mokhlesi B, Kryger MH, Grunstein RR. Assessment and Management of Patients with Obesity Hypoventilation Syndrome. Annals Of The American Thoracic Society 2008, 5: 218-225. PMID: 18250215, PMCID: PMC2645254, DOI: 10.1513/pats.200708-122mg.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObesity hypoventilation syndromeSleep-disordered breathingHypoventilation syndromeManagement of patientsAvailable treatment modalitiesRelated health care expendituresSerious cardiovascular diseaseHealth care expensesHealth care expendituresDaytime hypercapniaEucapnic patientsSignificant lungClinical characteristicsObese patientsSignificant morbidityEarly mortalityTreatment modalitiesEarly recognitionExtreme obesityCardiovascular diseaseHigh burdenEffective treatmentHigh riskHigh indexClinical practice
1996
Utilization of Health Care Services in Patients With Severe Obstructive Sleep Apnea
Kryger M, Roos L, Delaive K, Walld R, Horrocks J. Utilization of Health Care Services in Patients With Severe Obstructive Sleep Apnea. Sleep 1996, 19: s111-s116. PMID: 9122567, DOI: 10.1093/sleep/19.suppl_9.s111.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHealth care servicesSleep apneaControl groupCare servicesSevere obstructive sleep apneaHealth care utilizationSleep apnea patientsObese patientsOSA patientsCare utilizationInitial diagnosisOSA groupControl subjectsApnea patientsHospital costsPhysician claimsPatientsApneaControl counterpartsHeavy consumersSpecific evaluationGroupTotal expenditureHospital
1992
MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA
Kryger M. MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA. Clinics In Chest Medicine 1992, 13: 481-492. PMID: 1521414, DOI: 10.1016/s0272-5231(21)00875-3.Peer-Reviewed Original ResearchConceptsPositive airway pressureObstructive sleep apneaAirway pressureSleep apneaNasal continuous positive airway pressureBilevel positive airway pressureContinuous positive airway pressureGeneral therapeutic measuresUpper airway abnormalitiesMinority of patientsLong-term efficacyHours of sleepHypopnea frequencyAirway abnormalitiesObese patientsSurgical managementDrug therapyTherapeutic measuresEffective treatmentPatientsSpecific abnormalitiesApneaWeight lossTreatmentAbnormalities
1988
Sleep Apnea and Body Position during Sleep
George C, Millar T, Kryger M. Sleep Apnea and Body Position during Sleep. Sleep 1988, 11: 90-99. PMID: 3363274, DOI: 10.1093/sleep/11.1.90.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexRapid eye movementLateral decubitus positionApnea durationObese patientsSleep apneaDecubitus positionBody positionSleep stagesSevere sleep apneaObstructive sleep apneaNon-REM sleepMajor treatment interventionApnea frequencyOvernight studyPatientsTreatment interventionsApneaNREMEye movementsSleepPrevious studiesPolysomnogramSupinePosition changes
1983
The role of protriptyline in obstructive sleep apnea.
Brownell L, Perez-Padilla R, West P, Kryger M. The role of protriptyline in obstructive sleep apnea. Bulletin Européen De Physiopathologie Respiratoire 1983, 19: 621-4. PMID: 6360257.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTreatment of mildLong-term treatmentTricyclic agentsObese patientsObstructive apneaClinical statusCrossover trialImproved oxygenationInvasive treatmentTerm treatmentPatientsApneaArousal frequencySomnolenceProtriptylineTreatmentTrialsOxygenationREMTherapyMildMonths
1974
The sleep deprivation syndrome of the obese patient A problem of periodic nocturnal upper airway obstruction
Kryger M, Quesney L, Holder D, Gloor P, MacLeod P. The sleep deprivation syndrome of the obese patient A problem of periodic nocturnal upper airway obstruction. The American Journal Of Medicine 1974, 56: 531-539. PMID: 4818419, DOI: 10.1016/0002-9343(74)90485-9.Peer-Reviewed Original ResearchConceptsUpper airway obstructionSleep deprivation syndromeAirway obstructionUrinary incontinenceDeprivation syndromeNocturnal upper airway obstructionObese menObese patientsPickwickian syndromeUpper airwayVentilatory responseSyndromeObstructionFat depositionArousal patternsIncontinenceSomnolenceBradycardiaSuch findingsTracheostomyAirwayPatientsPathophysiologySleep