1987
Snoring in Normal Young Adults: Prevalence in Sleep Stages and Associated Changes in Oxygen Saturation, Heart Rate, and Breathing Pattern
Perez-Padilla J, West P, Kryger M. Snoring in Normal Young Adults: Prevalence in Sleep Stages and Associated Changes in Oxygen Saturation, Heart Rate, and Breathing Pattern. Sleep 1987, 10: 249-253. PMID: 3629087, DOI: 10.1093/sleep/10.3.249.Peer-Reviewed Original ResearchConceptsHeart rateContinuous snoringSleep stagesOxygen saturationPrevalence of snoringSignificant O2 desaturationMean heart rateNormal young adultsMean SaO2O2 desaturationDifferent pathogenesisDifferent sleep stagesNormal subjectsBreathing patternLight snorersBreathing frequencySnoringArrhythmiasYoung adultsPrevalenceStage 3Same sleep stageStage 2Associated ChangesSubjects
1984
Breathing Patterns in Patients with Chronic Obstructive Pulmonary Disease1,2
Loveridge B, West P, Anthonisen N, Kryger M. Breathing Patterns in Patients with Chronic Obstructive Pulmonary Disease1,2. American Journal Of Respiratory And Critical Care Medicine 1984, 130: 730-3. PMID: 6497155, DOI: 10.1164/arrd.1984.130.5.730.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCOPD groupRespiratory inductance plethysmographRib cageStable chronic obstructive pulmonary diseaseSex-matched control subjectsChronic obstructive pulmonaryObstructive pulmonary diseaseTi/TtotCOPD patientsMean PaO2Pulmonary diseaseControl subjectsMinute ventilationExpiratory timeInspiratory flowSitting positionTidal volumeNormal subjectsBreathing patternInductance plethysmographPatientsRespiratory cycleMean numberNeural control
1982
Sleep, Arousals, and Oxygen Desaturation in Chronic Obstructive Pulmonary Disease
Fleetham J, West P, Mezon B, Conway W, Roth T, Kryger M. Sleep, Arousals, and Oxygen Desaturation in Chronic Obstructive Pulmonary Disease. American Journal Of Respiratory And Critical Care Medicine 1982, 126: 429-33. PMID: 7125332, DOI: 10.1164/arrd.1982.126.3.429.Peer-Reviewed Original ResearchConceptsOxygen desaturationArousal frequencySleep qualityChronic obstructive pulmonary diseaseAge-matched normal subjectsLower mean SaO2Role of hypoxemiaArterial oxygen desaturationObstructive pulmonary diseaseRoom air breathingArterial O2 saturationPoor sleep qualityReduced sleep timeSleep stage changesApneic episodesPulmonary functionOxygen therapyPulmonary diseaseSupplemental oxygenMean SaO2Sleep disruptionREM sleepNormal subjectsO2 saturationPatients
1978
Excessive Polycythemia of High Altitude: Role of Ventilatory Drive and Lung Disease1–3
Kryger M, McCullough R, Doekel R, Collins D, Weil J, Grover R. Excessive Polycythemia of High Altitude: Role of Ventilatory Drive and Lung Disease1–3. American Journal Of Respiratory And Critical Care Medicine 1978, 118: 659-666. PMID: 707889, DOI: 10.1164/arrd.1978.118.4.659.Peer-Reviewed Original ResearchConceptsCause of hypoxemiaExcessive polycythemiaPolycythemic patientsTidal volumeNormal subjectsExcessive hypoxemiaChemical driveAbnormal breathing patternsAlveolar-arterial differenceSmall tidal volumesHigh-altitude residentsRespiratory QuestionnaireSpirometric featuresHypoxic depressionVentilatory driveLung diseaseControl subjectsVentilatory responseMinute ventilationNormal lungBreathing patternHypoxemiaPatientsPolycythemiaDead space
1976
Clinical Semi-Starvation — Depression of Hypoxic Ventilatory Response
Doekel R, Zwillich C, Scoggin C, Kryger M, Weil J. Clinical Semi-Starvation — Depression of Hypoxic Ventilatory Response. New England Journal Of Medicine 1976, 295: 358-361. PMID: 819829, DOI: 10.1056/nejm197608122950703.Peer-Reviewed Original ResearchConceptsHypoxic ventilatory responseVentilatory responseHypercapnic ventilatory responseMetabolic rateRespiratory failureIntravenous fluidsDecreased metabolic rateCarbohydrate dietNormal subjectsCaloric restrictionDay 10HypercapniaSupplemental electrolytesResponse responseSubjectsResponseHypoxemiaDecreaseHypoxiaAlimentationEffect of Meperidine on Occlusion Pressure Responses to Hypercapnia and Hypoxia with and without External Inspiratory Resistance1–3
Kryger M, Yacoub O, Dosman J, Macklem P, Anthonisen N. Effect of Meperidine on Occlusion Pressure Responses to Hypercapnia and Hypoxia with and without External Inspiratory Resistance1–3. American Journal Of Respiratory And Critical Care Medicine 1976, 114: 333-40. PMID: 973724, DOI: 10.1164/arrd.1976.114.2.333.Peer-Reviewed Original ResearchConceptsInspiratory resistanceNormal subjectsOcclusion pressure responsesInspiratory motor outputEffect of meperidineOral meperidineVentilatory responseAcute increaseInspiratory effortClosed airwayMeperidineHypercapniaProgressive hypoxiaMotor outputMore depressionHypoxiaHypoxic responsePressure responseP0.1Combination of resistanceSubjectsResponseAirway
1975
Effect of inspiratory resistance on occlusion pressure in hypoxia and hypercapnia
Kryger M, Yacoub O, Anthonisen N. Effect of inspiratory resistance on occlusion pressure in hypoxia and hypercapnia. Respiratory Physiology & Neurobiology 1975, 24: 241-248. PMID: 1188196, DOI: 10.1016/0034-5687(75)90016-x.Peer-Reviewed Original Research