Excessive Polycythemia of High Altitude: Role of Ventilatory Drive and Lung Disease1–3
Kryger M, McCullough R, Doekel R, Collins D, Weil J, Grover R. Excessive Polycythemia of High Altitude: Role of Ventilatory Drive and Lung Disease1–3. American Journal Of Respiratory And Critical Care Medicine 1978, 118: 659-666. PMID: 707889, DOI: 10.1164/arrd.1978.118.4.659.Peer-Reviewed Original ResearchConceptsCause of hypoxemiaExcessive polycythemiaPolycythemic patientsTidal volumeNormal subjectsExcessive hypoxemiaChemical driveAbnormal breathing patternsAlveolar-arterial differenceSmall tidal volumesHigh-altitude residentsRespiratory QuestionnaireSpirometric featuresHypoxic depressionVentilatory driveLung diseaseControl subjectsVentilatory responseMinute ventilationNormal lungBreathing patternHypoxemiaPatientsPolycythemiaDead spaceTreatment of Excessive Polycythemia of High Altitude with Respiratory Stimulant Drugs1–3
Kryger M, McCullough R, Collins D, Scoggin C, Weil J, Grover R. Treatment of Excessive Polycythemia of High Altitude with Respiratory Stimulant Drugs1–3. American Journal Of Respiratory And Critical Care Medicine 1978, 117: 455-64. PMID: 629480, DOI: 10.1164/arrd.1978.117.3.455.Peer-Reviewed Original ResearchConceptsMedroxyprogesterone acetateExcessive polycythemiaTidal volumeVentilatory responseArterial PCO2O2 saturationWeeks of therapyMonths of treatmentEffect of medroxyprogesteroneHypoxic ventilatory responseArterial O2 saturationNormal arterial PCO2Progestational agentsArterial PO2Normal lungStimulant effectsExcessive hypoxemiaPatientsMedroxyprogesteroneNormal valuesPolycythemiaDead spaceVentilationTherapyHematocrit