1987
Hypercapnia and Sleep O2 Desaturation in Chronic Obstructive Pulmonary Disease
Kryger M, Rogelio P, Conway W, Roth T, Anthonisen N, George C. Hypercapnia and Sleep O2 Desaturation in Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 216-223. PMID: 3629083, DOI: 10.1093/sleep/10.3.216.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseBlue bloatersPink puffersSleep hypoxemiaPulmonary diseaseO2 desaturationHypoxemic chronic obstructive pulmonary diseaseNocturnal Oxygen Therapy TrialBetter lung functionArterial blood gasesWide clinical spectrumHypercapnic patientsSame PaO2Sleep oxygenationSleep SaO2Airflow obstructionHypoxemic patientsPulmonary hypertensionCOPD populationHypercapnic groupMost patientsNormocapnic patientsLung functionBlood gases
1981
Sleep Disorders in Chronic Airflow Obstruction
Fleetham J, Kryger M. Sleep Disorders in Chronic Airflow Obstruction. Medical Clinics Of North America 1981, 65: 549-561. PMID: 7017303, DOI: 10.1016/s0025-7125(16)31513-9.Peer-Reviewed Original ResearchConceptsChronic airflow obstructionAirflow obstructionPulmonary hypertensionCardiac arrhythmiasLess rapid eye movement sleepRapid eye movement (REM) sleepSecondary pulmonary hypertensionNocturnal oxygen therapyGas exchange abnormalitiesSleep apnea syndromeEye movement sleepSleep stage changesApnea syndromeOxygen therapyPhysiologic disturbancesMovement sleepSleep disordersSleep profilesPatientsObstructionSleepHypertensionArrhythmiasStage changesSyndrome