2023
Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms
Bellamkonda K, Zogg C, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Ochoa Chaar C. Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms. Journal Of Vascular Surgery 2023, 77: 1649-1657. PMID: 36796595, DOI: 10.1016/j.jvs.2023.02.003.Peer-Reviewed Original ResearchConceptsEndovascular aneurysm repairAbdominal aortic aneurysmRAAA casesRAAA groupElective repairAneurysm repairAortic aneurysmMyocardial infarctionVascular Quality Initiative databaseLower body mass indexSmall abdominal aortic aneurysmsMean aneurysm diameterVascular Surgery guidelinesLong-term mortalityOutcomes of patientsPerioperative myocardial infarctionOpen AAA repairBody mass indexLong-term outcomesOperative thresholdAfrican AmericansInfrarenal aneurysmsTotal morbidityAAA repairPatient characteristics
2022
Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging. Journal Of Nuclear Medicine 2022, 63: 986-994. PMID: 35772956, PMCID: PMC9258561, DOI: 10.2967/jnumed.121.263507.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular imagingDevice-related thrombusDetection of thrombusUnmet diagnostic needsFibroblast activation proteinCardiovascular fibrosisCardiovascular inflammationRisk stratificationDiagnostic needsCardiovascular calcificationMyocardial infarctionInflammatory responseUnmet ClinicalNew radiotracersCardiovascular medicinePersonalized therapyFibrosisActivation proteinSPECT imagingAmyloidosisCalcificationThrombosisInflammationRadiotracer developmentThrombus
2010
Imaging Atherosclerosis and Vulnerable Plaque
Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL. Imaging Atherosclerosis and Vulnerable Plaque. Journal Of Nuclear Medicine 2010, 51: 51s-65s. PMID: 20395341, PMCID: PMC2911776, DOI: 10.2967/jnumed.109.068163.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisClinical Trials as TopicContrast MediaExtracellular MatrixFerric CompoundsFluorodeoxyglucose F18HumansInflammationMagnetic Resonance ImagingNanoparticlesNeovascularization, PathologicRiskThrombosisTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsTotal atherosclerotic burdenAcute cardiovascular eventsAtherosclerotic burdenCardiovascular eventsVascular thrombosisPlaque inflammationMyocardial infarctionPlaque stabilityFibrin depositsVulnerable plaquesHigh riskVasa vasorumPlaque evolutionSame imaging sessionVascular imagingVessel wallImaging sessionClinical translationBiologic processesModalitiesAnatomyExtracellular matrix
2009
Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury.
Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. Journal Of Physiology And Pharmacology 2009, 60 Suppl 4: 117-23. PMID: 20083860.Peer-Reviewed Original ResearchConceptsMyocardial hypertrophyHypoxic myocardiumMyocardial infarctionRat modelPressure overload-induced myocardial hypertrophyNon-invasive imaging strategyDeficient blood flowDegree of hypoperfusionAbdominal aortic bandingAnterior lateral wallLeft ventricular remodelingIschemic rat modelMarkers of angiogenesisHypoxia-induced angiogenesisPotential clinical useIschemic injuryAortic bandingVentricular remodelingAlphavbeta3 integrin receptorMyocardial hypoxiaImmunohistochemical stainingMyocardial uptakeRodent modelsBlood flowMyocardial segments
2008
Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction
Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ. Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. Journal Of Applied Physiology 2008, 104: 1504-1512. PMID: 18356482, DOI: 10.1152/japplphysiol.00861.2007.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBiomarkersBiotransformationDogsHeterocyclic Compounds, 1-RingHypoxiaImidazolesImmunohistochemistryIntegrin alphaVbeta3IntegrinsMaleMyocardial InfarctionMyocardial IschemiaMyocardiumNeovascularization, PhysiologicOrganometallic CompoundsOrganotechnetium CompoundsRadiopharmaceuticalsRatsRats, Sprague-DawleyTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsMyocardial infarctionInfarct regionCanine studyIschemic heart diseaseCoronary artery occlusionAcute myocardial infarctionMarkers of angiogenesisEx vivo analysisExpression/activationPotential novel targetHypoxia-induced angiogenesisVivo SPECT imagingAlphavbeta3 integrinBRU59-21Artery occlusionNovel noninvasive approachHeart diseaseHistological evidenceMyocardial hypoxiaMyocardial uptakeRP748Rodent studiesAngiogenic therapyInfarctionMyocardial angiogenesis
2004
Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction
Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. Journal Of Clinical Investigation 2004, 113: 1684-1691. PMID: 15199403, PMCID: PMC420502, DOI: 10.1172/jci20352.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCoronary VesselsDiagnostic ImagingDogsEndothelial CellsEndothelium, VascularHemodynamicsIndium RadioisotopesIntegrin alphaVbeta3MaleMolecular StructureMyocardial InfarctionMyocardiumNeovascularization, PhysiologicQuinolonesRadiopharmaceuticalsRatsRats, Sprague-DawleyTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsMyocardial angiogenesisMyocardial infarctionRadiotracer uptakeInjury-induced angiogenesisChronic rat modelNoninvasive imaging strategiesTherapeutic myocardial angiogenesisExperimental myocardial infarctionFocal radiotracer uptakePotential novel targetSignificant clinical utilityAlphavbeta3 integrinRisk stratificationHistological evidenceHypoperfused regionsRat modelMyocardial radiotracer uptakeClinical utilityNoninvasive evaluationAngiogenic therapyCanine modelInfarct regionInfarctionNovel targetNoninvasive imaging