2024
Clinical outcomes of SARS‐CoV‐2 infection in kidney transplant recipients on belatacept: a single‐center experience
Feller F, Azar M, Marvin J, Cohen E, Virmani S, Malinis M. Clinical outcomes of SARS‐CoV‐2 infection in kidney transplant recipients on belatacept: a single‐center experience. Transplant Infectious Disease 2024, 26: e14253. PMID: 38351494, DOI: 10.1111/tid.14253.Peer-Reviewed Original Research
2022
Evaluating clinical effectiveness of SARS‐CoV‐2 vaccine in solid organ transplant recipients: A propensity score matched analysis
Tucker M, Azar MM, Cohen E, Gan G, Deng Y, Palacios C, Malinis M. Evaluating clinical effectiveness of SARS‐CoV‐2 vaccine in solid organ transplant recipients: A propensity score matched analysis. Transplant Infectious Disease 2022, 24: e13876. PMID: 35684932, PMCID: PMC9348300, DOI: 10.1111/tid.13876.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsSARS-CoV-2 infectionOrgan transplant recipientsCritical COVID-19Clinical effectivenessTransplant recipientsVaccine eraVaccinated solid organ transplant recipientsCOVID-19Propensity score-matched cohortSARS-CoV-2 vaccinationSevere coronavirus disease 2019Cause-specific Cox regression modelsCOVID-19-related mortalitySARS-CoV-2 vaccinesSARS-CoV-2 infection ratesCurrent vaccine recommendationsKey preventative strategiesPrimary vaccine seriesRetrospective cohort studyDoses of mRNACox regression modelCoronavirus disease 2019Poisson regression modelsVaccine seriesLaboratory Diagnosis for SARS-CoV-2 Infection
Christensen BB, Azar MM, Turbett SE. Laboratory Diagnosis for SARS-CoV-2 Infection. Infectious Disease Clinics Of North America 2022, 36: 327-347. PMID: 35636903, PMCID: PMC9141924, DOI: 10.1016/j.idc.2022.02.002.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionClinical syndromeMolecular testingPatient's clinical syndromeReverse transcriptase-polymerase chain reactionOptimal diagnostic testCOVID-19 infectionSymptom onsetAcute infectionAntigen testingSerologic testingAcute diagnosisPolymerase chain reactionLaboratory diagnosisDiagnostic testsInfectionChain reactionDiagnosisSyndromeTesting
2021
Longitudinal Immune Profiling of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection in a Solid Organ Transplant Recipient
Klein J, Brito AF, Trubin P, Lu P, Wong P, Alpert T, Peña-Hernández MA, Haynes W, Kamath K, Liu F, Vogels CBF, Fauver JR, Lucas C, Oh J, Mao T, Silva J, Wyllie AL, Muenker MC, Casanovas-Massana A, Moore AJ, Petrone ME, Kalinich CC, Dela Cruz C, Farhadian S, Ring A, Shon J, Ko AI, Grubaugh ND, Israelow B, Iwasaki A, Azar MM, Team F. Longitudinal Immune Profiling of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection in a Solid Organ Transplant Recipient. The Journal Of Infectious Diseases 2021, 225: 374-384. PMID: 34718647, PMCID: PMC8807168, DOI: 10.1093/infdis/jiab553.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfectionLongitudinal immune profilingTransplant recipientsImmune profilingPrimary SARS-CoV-2 infectionCD4 T cell poolMale renal transplant recipientSolid organ transplant recipientsSARS-CoV-2 reinfectionSARS-CoV-2 antibodiesSARS-CoV-2 infectionWhole viral genome sequencingRenal transplant recipientsImmune escape mutationsOrgan transplant recipientsT cell poolTime of reinfectionCoronavirus disease 2019Lower neutralization titersHumoral memory responsesViral genome sequencingInitial diagnosisImmunologic deficiencyHumoral responseImmunologic investigations
2020
Diagnostic Testing of COVID-19 in Solid Organ Transplantation: Current Clinical Application and Future Strategies
Trubin PA, Azar MM, Malinis M. Diagnostic Testing of COVID-19 in Solid Organ Transplantation: Current Clinical Application and Future Strategies. Current Transplantation Reports 2020, 7: 390-398. PMID: 33134033, PMCID: PMC7585558, DOI: 10.1007/s40472-020-00307-w.Peer-Reviewed Original ResearchSARS-CoV-2 infectionSolid organ transplantationInfection prevention practicesOrgan transplantationTransplant recipientsPolymerase chain reactionAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSolid organ transplant recipientsSyndrome coronavirus 2 infectionPrevention practicesCOVID-19 pandemicRecipient suitabilityCoronavirus 2 infectionOrgan transplant recipientsChain reactionCoronavirus disease 2019SARS-CoV-2Current clinical applicationsDiagnostic testing strategiesCOVID-19 diagnosticsMitigation of infectionPurpose of ReviewWhileOptimal donorViral kineticsDiagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome
Azar MM, Shin JJ, Kang I, Landry M. Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome. Expert Review Of Molecular Diagnostics 2020, 20: 1087-1097. PMID: 32990479, DOI: 10.1080/14737159.2020.1830760.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Immune profileCOVID-19SARS-CoV-2 infectionCytokine release syndromeAdaptive immune cellsMultiple inflammatory cytokinesSARS-CoV-2 RNAFalse-negative resultsRelease syndromeInfectious complicationsIL-10Laboratory markersD-dimerInflammatory moleculesIP-10IL-6Inflammatory cytokinesMCP-1Acute diagnosisIL-2Immune cellsClinical severityTherapeutic benefitPathogenic contribution