2001
Cilia propel the embryo in the right direction
Brueckner M. Cilia propel the embryo in the right direction. American Journal Of Medical Genetics 2001, 101: 339-344. PMID: 11471157, DOI: 10.1002/1096-8628(20010715)101:4<339::aid-ajmg1442>3.0.co;2-p.Peer-Reviewed Original Research
2000
Molecular motors: the driving force behind mammalian left–right development
Supp D, Potter S, Brueckner M, Supp D, Potter S, Brueckner M. Molecular motors: the driving force behind mammalian left–right development. Trends In Cell Biology 2000, 10: 41-45. PMID: 10652513, DOI: 10.1016/s0962-8924(99)01701-8.Peer-Reviewed Original ResearchConceptsEarly vertebrate developmentMitotic spindle movementsLarge protein complexesLeft-right developmentLeft-right axisEmbryonic patterningVertebrate developmentProtein complexesCellular processesMicrotubule cytoskeletonVesicular transportSpindle movementsATP hydrolysisMolecular motorsDirectional movementCiliary beatingUnique roleCytoskeletonKinesinPatterningComplexesHydrolysis
1999
Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries
Supp D, Brueckner M, Kuehn M, Witte D, Lowe L, McGrath J, Corrales J, Potter S. Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries. Development 1999, 126: 5495-5504. PMID: 10556073, PMCID: PMC1797880, DOI: 10.1242/dev.126.23.5495.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAmino Acid SequenceAnimalsAxonemal DyneinsBinding SitesBody PatterningCatalytic DomainCiliaCloning, MolecularDyneinsFunctional LateralityGene Expression Regulation, DevelopmentalHeadMaleMiceMice, Inbred StrainsMolecular Sequence DataMutationNervous SystemSequence AnalysisSequence DeletionConceptsLeft-right dyneinLeft-right developmentLeft-right asymmetryEmbryonic day 8.0Microtubule-based motor proteinsAsymmetric expression patternLevel of sequenceComplete coding sequenceEmbryonic day 7.5Single amino acid differenceLeft-right specificationAmino acid differencesLeft-right axisLgl mutantsATP bindingConserved positionDay 8.0Inversus viscerum (iv) mouseCoding sequenceMotor proteinsDorsoventral axesExpression patternsGerm layersAcid differencesGenes
1997
Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice
Supp D, Witte D, Potter S, Brueckner M. Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice. Nature 1997, 389: 963-966. PMID: 9353118, PMCID: PMC1800588, DOI: 10.1038/40140.Peer-Reviewed Original ResearchConceptsAxonemal dynein heavy chain geneDynein heavy chain geneAsymmetric expression patternMicrotubule-based motorsEmbryonic day 7.5Vertebrate patterningLeft-right axisGenetic hierarchyLeft-right asymmetryEarly molecular mechanismsPositional cloningHeavy chain geneInversus viscerum (iv) mouseGene productsVisceral asymmetryAxonemal dyneinsSymmetrical embryosExpression patternsMolecular mechanismsLR determinationMolecular levelDay 7.5EmbryosLateralization defectsDynein
1996
Laterality disturbances
Bowers P, Brueckner M, Yost H. Laterality disturbances. Progress In Pediatric Cardiology 1996, 6: 53-62. DOI: 10.1016/1058-9813(96)00171-3.Peer-Reviewed Original ResearchLeft-right body axisBody axisEmbryonic left-right axisPrimitive heart tubeLeft-right axisLeft-right asymmetryCardiac morphogenesisHeart developmentDevelopmental processesDorsoventral axesGenetic stepsHeart tubeMolecular levelLoop formationLaterality disturbancesComplex groupMorphogenesisFormation resultsVisible asymmetry
1991
Establishment of Left‐Right Asymmetry in Vertebrates: Genetically Distinct Steps are Involved
Brueckner M, McGrath J, D'Eustachio P, Horwich A. Establishment of Left‐Right Asymmetry in Vertebrates: Genetically Distinct Steps are Involved. Novartis Foundation Symposia 1991, 162: 202-218. PMID: 1802643, DOI: 10.1002/9780470514160.ch12.Peer-Reviewed Original ResearchConceptsRestriction fragment length polymorphism (RFLP) markersFragment length polymorphism (AFLP) markersMouse chromosome 12Length polymorphism markersTiming of expressionLeft-right determinationLeft-right axisLeft-right asymmetryPositional cloningPolymorphism markersRecessive allelesGene productsPattern of inheritanceChromosome 12Developmental pathwaysLinkage analysisCardiac tubeFunction mutationsGenesMolecular analysisDevelopmental stepsFirst organAffected embryosVertebratesDistinct phenotypes