2021
STING enhances cell death through regulation of reactive oxygen species and DNA damage
Hayman TJ, Baro M, MacNeil T, Phoomak C, Aung TN, Cui W, Leach K, Iyer R, Challa S, Sandoval-Schaefer T, Burtness BA, Rimm DL, Contessa JN. STING enhances cell death through regulation of reactive oxygen species and DNA damage. Nature Communications 2021, 12: 2327. PMID: 33875663, PMCID: PMC8055995, DOI: 10.1038/s41467-021-22572-8.Peer-Reviewed Original Research
2019
Neuregulin Signaling Is a Mechanism of Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma
Baro M, Lopez Sambrooks C, Burtness BA, Lemmon MA, Contessa JN. Neuregulin Signaling Is a Mechanism of Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma. Molecular Cancer Therapeutics 2019, 18: 2124-2134. PMID: 31387891, PMCID: PMC6825559, DOI: 10.1158/1535-7163.mct-19-0163.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCell Line, TumorCell ProliferationCell SurvivalCetuximabDrug Resistance, NeoplasmFemaleHead and Neck NeoplasmsHumansMiceNeuregulinsProto-Oncogene Proteins c-aktReceptor, ErbB-3Signal TransductionSquamous Cell Carcinoma of Head and NeckUp-RegulationXenograft Model Antitumor AssaysConceptsNeck squamous cell carcinomaSquamous cell carcinomaTherapeutic resistanceCell carcinomaResistant cellsConcentrations of cetuximabEFM-19 cellsCetuximab-resistant cellsActionable therapeutic targetsHNSCC cell linesTumor growth experimentsInhibition of EGFRErbB3 antibodyNeuregulin expressionOverall survivalTreatment regimensCetuximab resistanceTherapeutic targetAutocrine loopLocal controlTumor growthRadiotherapyEGFR inhibitionCetuximabNeuregulin Signaling
2014
Dasatinib worsens the effect of cetuximab in combination with fractionated radiotherapy in FaDu- and A431-derived xenografted tumours
Baro M, de Llobet L, Figueras A, Skvortsova I, Mesia R, Balart J. Dasatinib worsens the effect of cetuximab in combination with fractionated radiotherapy in FaDu- and A431-derived xenografted tumours. British Journal Of Cancer 2014, 111: 1310-1318. PMID: 25077442, PMCID: PMC4183853, DOI: 10.1038/bjc.2014.432.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsCell Line, TumorCell ProliferationCetuximabDasatinibDNA ReplicationDose Fractionation, RadiationFemaleHumansMiceMice, NudeNeovascularization, PathologicPyrimidinesRas ProteinsSrc-Family KinasesThiazolesTumor BurdenVascular Endothelial Growth Factor AXenograft Model Antitumor Assays
2012
Development and refinement of a technique using a medical radiation therapy facility to irradiate immunodeficient mice bearing xenografted human tumours
Baro M, de Llobet L, Modolell I, Guedea F, Visa J, Balart J. Development and refinement of a technique using a medical radiation therapy facility to irradiate immunodeficient mice bearing xenografted human tumours. Laboratory Animals 2012, 46: 345-348. PMID: 22723647, DOI: 10.1258/la.2012.011147.Peer-Reviewed Original ResearchDevelopment and characterization of an isogenic cell line with a radioresistant phenotype
de Llobet L, Baro M, Figueras A, Modolell I, Da Silva M, Muñoz P, Navarro A, Mesia R, Balart J. Development and characterization of an isogenic cell line with a radioresistant phenotype. Clinical And Translational Oncology 2012, 15: 189-197. PMID: 22855182, DOI: 10.1007/s12094-012-0898-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternCarcinoma, Squamous CellCell CycleCell MovementCell ProliferationDose-Response Relationship, RadiationFemaleFlow CytometryGamma RaysHumansHyaluronan ReceptorsMiceMice, NudePhenotypeRadiation ToleranceTumor Cells, CulturedVascular Endothelial Growth Factor AWound HealingXenograft Model Antitumor AssaysConceptsCell linesIsogenic cancer cell linesIsogenic cell linesRadiation-induced DNA fragmentationCancer cellsSpecific cell functionsDNA repair abilityBiological traitsAppropriate study modelsCell cycle distributionVascular endothelial growth factor (VEGF) secretionMolecular characterizationCell survivalDNA fragmentationRadioresistant phenotypeCell growthCancer cell linesSecretion of VEGFGrowth factor secretionSingle cellsCycle distributionCell functionRepair abilityRadiation resistanceWestern blot