2022
Vancomycin Should Be Considered a Nephrotoxic Antimicrobial Agent: COMMENTARY
Perazella MA. Vancomycin Should Be Considered a Nephrotoxic Antimicrobial Agent: COMMENTARY. Kidney360 2022, 3: 1491-1493. PMID: 36250736, PMCID: PMC9528384, DOI: 10.34067/kid.0008112021.Peer-Reviewed Original ResearchSevere AKI in a Patient on Multiple Antimicrobial Agents for Leg Infection
Rehan A, Moeckel GW, Perazella MA. Severe AKI in a Patient on Multiple Antimicrobial Agents for Leg Infection. Kidney360 2022, 3: 405-406. PMID: 35373119, PMCID: PMC8967631, DOI: 10.34067/kid.0006102021.Peer-Reviewed Original Research
1999
Trimethoprim-Sulfamethoxazole Therapy in Outpatients: Is Hyperkalemia a Significant Problem?
Alappan R, Buller G, Perazella M. Trimethoprim-Sulfamethoxazole Therapy in Outpatients: Is Hyperkalemia a Significant Problem? American Journal Of Nephrology 1999, 19: 389-394. PMID: 10393376, DOI: 10.1159/000013483.Peer-Reviewed Original ResearchConceptsSerum potassium concentrationSerum creatinine levelsTrimethoprim-sulfamethoxazole therapyBaseline serum potassium concentrationVariety of infectionsCreatinine levelsDay 5Treatment groupsPotassium concentrationControl groupMean serum potassium concentrationBlood urea nitrogen levelsDevelopment of hyperkalemiaLife-threatening hyperkalemiaMild renal insufficiencyDays of therapyHigher serum potassium concentrationsImmunodeficiency syndrome (AIDS) patientsUrea nitrogen levelsSerum glucose concentrationRelevant hyperkalemiaOral antibioticsRenal insufficiencyMost patientsSevere hyperkalemia
1996
Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose.
Perazella M, Mahnensmith R. Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose. Clinical Nephrology 1996, 46: 187-92. PMID: 8879854.Peer-Reviewed Original ResearchConceptsTrimethoprim-sulfamethoxazole therapyStandard doseDevelopment of hyperkalemiaTrimethoprim-sulfamethoxazole useMild renal insufficiencyProspective surveillance studyPotassium-sparing diuretic amilorideRenal potassium excretionPneumocystis carinii pneumoniaLethal adverse reactionHandful of casesRenal insufficiencyElderly patientsPotassium excretionSevere hyperkalemiaImportant complicationAIDS patientsCarinii pneumoniaTrimethoprim-sulfamethoxazoleAdverse reactionsInduced hyperkalemiaPotassium disordersHyperkalemiaSurveillance studyPatients