2000
Acute Renal Failure in HIV-Infected Patients: A Brief Review of Common Causes
Perazella M. Acute Renal Failure in HIV-Infected Patients: A Brief Review of Common Causes. The American Journal Of The Medical Sciences 2000, 319: 385-391. DOI: 10.1016/s0002-9629(15)40779-7.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAcute renal failureRenal failureCommon causeAcute renal insufficiencyTumor lysis syndromeRenal tubular functionNephrotoxic medicationsPostrenal azotemiaLysis syndromePrerenal azotemiaRenal insufficiencyCrystal nephropathyNephrotoxic insultsTubular functionImmunodeficiency virusIschemic processIntravascular volumeGlomerular diseaseAllergic reactionsRenal syndromeUrinary systemPatientsRenal tubulesGlomerular capillariesAre selective COX-2 inhibitors nephrotoxic?
Perazella M, Eras J. Are selective COX-2 inhibitors nephrotoxic? American Journal Of Kidney Diseases 2000, 35: 937-940. PMID: 10793030, DOI: 10.1016/s0272-6386(00)70266-6.Peer-Reviewed Original ResearchConceptsHigh-risk patientsRenal insufficiencySelective cyclooxygenase-2 enzyme inhibitorsSuch high-risk patientsNonsteroidal anti-inflammatory drugsSelective COX-2 inhibitorsChronic renal impairmentChronic renal insufficiencyAcute renal failureAcute renal insufficiencyAdverse gastrointestinal effectsCyclooxygenase-2 enzyme inhibitorsAnti-inflammatory drugsCourse of therapyCOX-2 inhibitorsPain syndromeRenal impairmentRenal failureGastrointestinal effectsNephrotoxic potentialInflammatory diseasesEnzyme inhibitorsPatientsInsufficiencyInhibitors
1999
Trimethoprim-Sulfamethoxazole Therapy in Outpatients: Is Hyperkalemia a Significant Problem?
Alappan R, Buller G, Perazella M. Trimethoprim-Sulfamethoxazole Therapy in Outpatients: Is Hyperkalemia a Significant Problem? American Journal Of Nephrology 1999, 19: 389-394. PMID: 10393376, DOI: 10.1159/000013483.Peer-Reviewed Original ResearchConceptsSerum potassium concentrationSerum creatinine levelsTrimethoprim-sulfamethoxazole therapyBaseline serum potassium concentrationVariety of infectionsCreatinine levelsDay 5Treatment groupsPotassium concentrationControl groupMean serum potassium concentrationBlood urea nitrogen levelsDevelopment of hyperkalemiaLife-threatening hyperkalemiaMild renal insufficiencyDays of therapyHigher serum potassium concentrationsImmunodeficiency syndrome (AIDS) patientsUrea nitrogen levelsSerum glucose concentrationRelevant hyperkalemiaOral antibioticsRenal insufficiencyMost patientsSevere hyperkalemiaCrystal-induced acute renal failure
Perazella M. Crystal-induced acute renal failure. The American Journal Of Medicine 1999, 106: 459-465. PMID: 10225250, DOI: 10.1016/s0002-9343(99)00041-8.Peer-Reviewed Original ResearchConceptsAcute renal failureRenal insufficiencyRenal failureVolume repletionAppropriate drug dosingIntrarenal crystal depositionAcute renal insufficiencyIntravascular volume depletionAdditional risk factorsHigh urinary flowDialytic supportUrinary flowRisk factorsVolume depletionDrug dosingDrug dosesCrystal depositionIntratubular precipitationInsufficiencyUrineMedicationsRepletionFurther exposureFailureHuman urine
1998
Acute Renal Failure and Intravenous Immune Globulin
Perazella M, Cayco A. Acute Renal Failure and Intravenous Immune Globulin. American Journal Of Therapeutics 1998, 5: 399-404. PMID: 10099084, DOI: 10.1097/00045391-199811000-00008.Peer-Reviewed Original ResearchConceptsAcute renal failureRenal failureRenal insufficiencyIntravenous immune globulin therapyImmune globulin therapyChronic renal insufficiencyIntravenous immune globulinAcute renal insufficiencyRenal replacement therapyVariety of complicationsGlobulin therapyIVIG infusionIVIG therapyMaintenance dialysisRenal impairmentImmune globulinIVIG preparationsReplacement therapyDrug trialsNumber of casesClinical disordersOlder agePrecise causeTherapyAdverse effectsIndinavir nephropathy in an AIDS patient with renal insufficiency and pyuria.
Perazella M, Kashgarian M, Cooney E. Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria. Clinical Nephrology 1998, 50: 194-6. PMID: 9776425.Peer-Reviewed Original ResearchConceptsRenal biopsy findingsRenal insufficiencyBiopsy findingsMild renal insufficiencyAcute renal failureIndinavir crystalsIndinavir therapyRenal failureAntiretroviral agentsUrinary obstructionAIDS patientsCellular castsPatientsPyuriaInsufficiencyRecent reportsSmall percentDiscontinuationNephropathyMedicationsSecond caseDiuresisNephrolithiasisIndinavirObstruction
1997
Renal insufficiency after intravenous immune globulin therapy: a report of two cases and an analysis of the literature.
Cayco A, Perazella M, Hayslett J. Renal insufficiency after intravenous immune globulin therapy: a report of two cases and an analysis of the literature. Journal Of The American Society Of Nephrology 1997, 8: 1788-94. PMID: 9355083, DOI: 10.1681/asn.v8111788.Peer-Reviewed Original ResearchConceptsIntravenous immune globulin therapyAcute renal failureImmune globulin therapyGlobulin therapyRenal replacement therapyNumber of complicationsIVIG treatmentRenal insufficiencyRenal failureRenal injuryIVIG preparationsSuch patientsReplacement therapyClinical disordersTherapyCases recoveryComplicationsPatientsRecurrenceWidespread useInjuryInsufficiencyAgentsCases
1996
Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose.
Perazella M, Mahnensmith R. Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose. Clinical Nephrology 1996, 46: 187-92. PMID: 8879854.Peer-Reviewed Original ResearchConceptsTrimethoprim-sulfamethoxazole therapyStandard doseDevelopment of hyperkalemiaTrimethoprim-sulfamethoxazole useMild renal insufficiencyProspective surveillance studyPotassium-sparing diuretic amilorideRenal potassium excretionPneumocystis carinii pneumoniaLethal adverse reactionHandful of casesRenal insufficiencyElderly patientsPotassium excretionSevere hyperkalemiaImportant complicationAIDS patientsCarinii pneumoniaTrimethoprim-sulfamethoxazoleAdverse reactionsInduced hyperkalemiaPotassium disordersHyperkalemiaSurveillance studyPatientsHyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole.
Alappan R, Perazella M, Buller G. Hyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole. Annals Of Internal Medicine 1996, 124: 316-20. PMID: 8554227, DOI: 10.7326/0003-4819-124-3-199602010-00006.Peer-Reviewed Original ResearchConceptsSerum potassium concentrationSerum creatinine levelsMumol/LBlood urea nitrogen levelsPeak potassium concentrationTrimethoprim-sulfamethoxazole therapyCreatinine levelsUrea nitrogen levelsTrimethoprim-sulfamethoxazoleTreatment groupsPotassium concentrationControl groupCommunity-based teaching hospitalDevelopment of hyperkalemiaDays of therapyProspective chart reviewConcurrent renal insufficiencyRenal insufficiencyChart reviewSevere hyperkalemiaHospitalized patientsSerum sodiumTeaching hospitalAnion gapPatients
1993
NSAID Nephrotoxicity Revisited: Acute Renal Failure Due to Parenteral Ketorolac
PERAZELLA M, BULLER G. NSAID Nephrotoxicity Revisited: Acute Renal Failure Due to Parenteral Ketorolac. Southern Medical Journal 1993, 86: 1421-1424. PMID: 8272928, DOI: 10.1097/00007611-199312000-00025.Peer-Reviewed Original ResearchConceptsNSAID nephrotoxicityAcute renal failureSevere postoperative painMajor surgical proceduresKetorolac therapyParenteral ketorolacRenal hypoperfusionNonsurgical patientsPostoperative painRenal insufficiencyElderly patientsNonnarcotic analgesicsOral NSAIDsRenal failureRenal functionSuch patientsUrine outputSurgical proceduresKetorolacPatientsMedical literatureNephrotoxicitySuch proceduresSame degreeHypoperfusionRenal Failure and Severe Hypokalemia Associated With Acute Myelomonocytic Leukemia
Perazella M, Eisen R, Frederick W, Brown E. Renal Failure and Severe Hypokalemia Associated With Acute Myelomonocytic Leukemia. American Journal Of Kidney Diseases 1993, 22: 462-467. PMID: 8372846, DOI: 10.1016/s0272-6386(12)70154-3.Peer-Reviewed Original ResearchConceptsAcute myelomonocytic leukemiaRenal failureMyelomonocytic leukemiaRenal parenchymal infiltrationRenal tubular injuryHypokalemia AssociatedInappropriate kaliuresisMicrovascular insufficiencyRenal insufficiencySevere hypokalemiaTubular injuryParenchymal infiltrationSetting of leukemiaBlast cellsLeukemiaMetabolic perturbationsHypokalemiaVariety of mechanismsInsufficiencyFailureLeukostasisKaliuresisEtiologyInjury
1991
Can Ibuprofen Cause Acute Renal Failure in a Normal Individual? A Case of Acute Overdose
Perazella M, Buller G. Can Ibuprofen Cause Acute Renal Failure in a Normal Individual? A Case of Acute Overdose. American Journal Of Kidney Diseases 1991, 18: 600-602. PMID: 1951342, DOI: 10.1016/s0272-6386(12)80657-3.Peer-Reviewed Original ResearchConceptsNonsteroidal antiinflammatory drugsAcute renal failureRenal blood flowRenal failureAcute renal insufficiencyCase of AcuteRenal insufficiencyTubular necrosisAntiinflammatory drugsBlood flowRenal syndromeClinical situationsNormal individualsIbuprofenFailureAcutePatientsSyndromeInsufficiencyNecrosis