2014
Isoaspartyl modification of ZAP70 signaling molecule alters T cell responses (555.9)
Yang M, Clarke S, Mamula M. Isoaspartyl modification of ZAP70 signaling molecule alters T cell responses (555.9). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.555.9.Peer-Reviewed Original ResearchSystemic lupus erythematosusT cell responsesCell responsesT cell immune responsesCell immune responsesAutoreactive immune cellsT cell defectsMajor target organT-cell immunodeficiencyT cell hyperproliferationPIMT-deficient miceProtein L-isoaspartyl methyltransferaseLupus pathologyAutoimmune miceLupus erythematosusImmune toleranceImmune cellsDeficient miceCell immunodeficiencyImmune responseTarget organsT cell signalingImmune systemAutoimmune BCell hyperproliferation
2013
Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152)
Yang M, Connolly S, Wen L, Herold K, Mamula M. Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152). The Journal Of Immunology 2013, 190: 172.3-172.3. DOI: 10.4049/jimmunol.190.supp.172.3.Peer-Reviewed Original ResearchNOD miceType 1 diabetesDiabetes-prone NOD miceEarly-onset diabetic patientsPre-diabetic NOD miceDiabetic NOD miceT cell autoimmunityPathogenesis of T1DPancreatic islet proteinsCell autoimmunityDiabetic patientsImmune toleranceRheumatoid arthritisMultiple sclerosisAutoimmune diseasesMurine modelTarget organsTherapeutic targetSelf proteinsPancreatic isletsIslet proteinsMiceOxidative stressPeripheral erythrocytesDiabetes