1990
Effect of age on single- and multiple-dose pharmacokinetics of erythromycin
Miglioli P, Pivetta P, Strazzabosco M, Orlando R, Okolicsanyi L, Palatini P. Effect of age on single- and multiple-dose pharmacokinetics of erythromycin. European Journal Of Clinical Pharmacology 1990, 39: 161-164. PMID: 2253666, DOI: 10.1007/bf00280051.Peer-Reviewed Original ResearchConceptsElderly subjectsEffect of ageSerum concentrationsSerum concentration-time curveMultiple-dose pharmacokineticsApparent oral clearanceMultiple-dose regimenPeak serum concentrationHealthy elderly subjectsConcentration-time curvePharmacokinetics of erythromycinNormal elderly subjectsYoung healthy adultsMean eliminationTwo-fold accumulationFirst doseOral clearanceOral dosesMultiple dosesMultiple dosingPresystemic clearanceTime-dependent reductionErythromycin stearateAge-related differencesElderly group
1984
The pharmacokinetics of H2 receptor blocking agents in compensated liver cirrhosis.
Okolicsányi L, Venuti M, Strazzabosco M, Iemmolo R, Nassuato G, Orlando R, Lirussi F. The pharmacokinetics of H2 receptor blocking agents in compensated liver cirrhosis. Physiology International 1984, 64: 393-400. PMID: 6099684.Peer-Reviewed Original ResearchConceptsCompensated liver cirrhosisLiver cirrhosisPlasma concentrationsUrinary recoveryOral administrationDoses of cimetidinePharmacokinetics of cimetidineHigher plasma concentrationsSame plasma concentrationIntravenous cimetidineCirrhotic patientsSingle dosesH2 receptorsOral routeNormal subjectsPharmacokinetic parametersAdministration routeCimetidineRanitidineCirrhosisPharmacokineticsDosesPatientsAdministration