1993
Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL
Bruck R, Benedetti A, Strazzabosco M, Boyer J. Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL. American Journal Of Physiology 1993, 265: g347-g353. PMID: 8368316, DOI: 10.1152/ajpgi.1993.265.2.g347.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAlkaliesAnimalsAnionsBariumBicarbonatesBileBiological TransportColchicineExocytosisHorseradish PeroxidaseHydrogen-Ion ConcentrationIn Vitro TechniquesIntracellular MembranesLiverMalePotassium ChannelsRatsRats, Sprague-DawleyConceptsBiliary HCO3- excretionBile flowHCO3- excretionIntracellular alkalinizationHCO3- exchangerAcute alkaline loadVesicle-mediated exocytosisBiliary excretionTransient increasePH recoveryAlkaline loadMembrane depolarizationRat liverChannel blocker BaCl2Intact liverLiverAlkalinizationMM NH4ClHCO3- concentrationDisulfonic acidDIDSRat hepatocytesColchicinePretreatmentExocytosis
1986
The Effect of Drugs on Bile Flow and Composition
Okolicsanyi L, Lirussi F, Strazzabosco M, Jemmolo R, Orlando R, Nassuato G, Muraca M, Crepaldi G. The Effect of Drugs on Bile Flow and Composition. Drugs 1986, 31: 430-448. PMID: 2872047, DOI: 10.2165/00003495-198631050-00003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBileBile Acids and SaltsCatsChlorpromazineCholagogues and CholereticsCholesterolClofibrateColchicineCricetinaeDehydrocholic AcidDiureticsDogsEnterohepatic CirculationEstrogensGlucagonGuinea PigsHumansInsulinLiverMacaca mulattaPhospholipidsRabbitsRatsRifampinRifamycinsSomatostatinTheophyllineUrsodeoxycholic AcidConceptsBile flowBile acidsBile acid sequestrant cholestyramineBiliary bile acid secretionBiliary cholesterol concentrationBiliary cholesterol saturationBiliary cholesterol secretionBile acid concentrationsBile acid secretionBiliary phospholipid concentrationDrug-induced changesComposition of bileUnconjugated bile acidsEffects of drugsVariety of drugsCholesterol secretionHepatic secretionDrug therapyCholesterol saturationUrsodeoxycholic acidBiliary lipidsAcid secretionCholesterol concentrationsD-thyroxineHepatobiliary route