Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway
Cilibrasi C, Riva G, Romano G, Cadamuro M, Bazzoni R, Butta V, Paoletta L, Dalprà L, Strazzabosco M, Lavitrano M, Giovannoni R, Bentivegna A. Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway. PLOS ONE 2017, 12: e0169854. PMID: 28081224, PMCID: PMC5231344, DOI: 10.1371/journal.pone.0169854.Peer-Reviewed Original ResearchConceptsGlioma stem cellsGlioblastoma multiformeResveratrol exposureSolid tumorsPleiotropic health benefitsProtein levelsHigh recurrence rateMalignant brain tumorsBetter therapeutic strategiesCell proliferationEpithelial-mesenchymal transition (EMT) programGrade IV astrocytomaGSC linesInteresting therapeutic approachWnt Signaling PathwayMedian survivalRecurrence rateGlioma stem cell proliferationCurrent therapiesPathway-related genesPolyphenolic phytoalexinGBM patientsTherapeutic approachesTherapeutic strategiesBrain tumors