1999
The monoethylglycinexylidide test for grading of liver cirrhosis
FABRIS, JEMMOLO, TOFFOLO, PALEARI, VIAGGI, RIGON, CASAGRANDE, LIRUSSI, STRAZZABOSCO, COBELLI, OKOLICSANYI. The monoethylglycinexylidide test for grading of liver cirrhosis. Alimentary Pharmacology & Therapeutics 1999, 13: 67-75. PMID: 9892881, DOI: 10.1046/j.1365-2036.1999.00431.x.Peer-Reviewed Original ResearchConceptsLiver function testsCirrhotic patientsLignocaine injectionLiver cirrhosisFunction testsMEGX testMEGX concentrationsDynamic liver function testsQuantitative liver function testsCompensated liver cirrhosisGood diagnostic accuracyMonoethylglycinexylidide formationMonoethylglycinexylidide testMEGX formationSerum concentrationsPatientsDisease severityMin-1Diagnostic accuracyCirrhosisOptimal sampling timesGood discriminationInjectionNormals
1990
Effect of age on single- and multiple-dose pharmacokinetics of erythromycin
Miglioli P, Pivetta P, Strazzabosco M, Orlando R, Okolicsanyi L, Palatini P. Effect of age on single- and multiple-dose pharmacokinetics of erythromycin. European Journal Of Clinical Pharmacology 1990, 39: 161-164. PMID: 2253666, DOI: 10.1007/bf00280051.Peer-Reviewed Original ResearchConceptsElderly subjectsEffect of ageSerum concentrationsSerum concentration-time curveMultiple-dose pharmacokineticsApparent oral clearanceMultiple-dose regimenPeak serum concentrationHealthy elderly subjectsConcentration-time curvePharmacokinetics of erythromycinNormal elderly subjectsYoung healthy adultsMean eliminationTwo-fold accumulationFirst doseOral clearanceOral dosesMultiple dosesMultiple dosingPresystemic clearanceTime-dependent reductionErythromycin stearateAge-related differencesElderly group