2019
The tumour microenvironment and immune milieu of cholangiocarcinoma
Fabris L, Perugorria M, Mertens J, Björkström NK, Cramer T, Lleo A, Solinas A, Sänger H, Lukacs‐Kornek V, Moncsek A, Siebenhüner A, Strazzabosco M. The tumour microenvironment and immune milieu of cholangiocarcinoma. Liver International 2019, 39: 63-78. PMID: 30907492, PMCID: PMC10878127, DOI: 10.1111/liv.14098.Peer-Reviewed Original ResearchConceptsTumor microenvironmentAbundant desmoplastic reactionCancer-associated fibroblastsHigh mortality rateTumor-promoting functionsEpithelial cancer cellsImmune milieuImmune cellsPancreatic cancerEffective therapyDesmoplastic reactionMortality rateCholangiocarcinomaInvasive abilityTherapeutic gainStromal cellsTumor cellsEndothelial cellsEpithelial counterpartsCancer cellsIntrahepatic variantCellular populationsMicroenvironmentCellsRecent studies
2013
Unveiling the role of tumor reactive stroma in cholangiocarcinoma: an opportunity for new therapeutic strategies.
Cadamuro M, Morton SD, Strazzabosco M, Fabris L. Unveiling the role of tumor reactive stroma in cholangiocarcinoma: an opportunity for new therapeutic strategies. Translational Gastroenterology And Hepatology 2013, 2: 130-144. PMID: 28989865, PMCID: PMC5627657, DOI: 10.3978/j.issn.2224-4778.2013.04.02.Peer-Reviewed Original ResearchTumor reactive stromaReactive stromaTime of diagnosisRegional lymph nodesPotential new treatmentSpecific therapeutic interventionsNew therapeutic strategiesPro-invasive propertiesNumber of carcinomasCurative intentSurgical resectionLymph nodesCurative treatmentAggressive neoplasmPancreatic cancerBreast cancerTumor stromaTherapeutic strategiesCholangiocarcinomaEpidemiological impactTherapeutic chanceTherapeutic interventionsTumor growthNew treatmentsParacrine communication