2003
Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population
Neri T, Cavestro G, Seghini P, Zanelli P, Zanetti A, Savi M, Podda M, Zuin M, Colombo M, Floreani A, Rosina F, Porro G, Strazzabosco M, Okolicsanyi L. Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population. Digestive And Liver Disease 2003, 35: 571-576. PMID: 14567462, DOI: 10.1016/s1590-8658(03)00274-3.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisHLA-DRB1PSC patientsSclerosing cholangitisFrequency of patientsFrequency of DRB1Tumor necrosis factorPolymerase chain reaction-based methodologyMHC region genesNecrosis factorHLA haplotypeHLA-DQB1T polymorphismNormal controlsPatientsDRB1CFTR geneMajor histocompatibility complex (MHC) genesHLA regionHaplotype frequenciesSouthern European populationsCystic fibrosis transmembrane conductance regulator (CFTR) geneCholangitisDNA levelsHomozygous genotype
2001
Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium
Spirlı̀ C, Nathanson M, Fiorotto R, Duner E, Denson L, Sanz J, Di Virgilio F, Okolicsanyi L, Casagrande F, Strazzabosco M. Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium. Gastroenterology 2001, 121: 156-169. PMID: 11438505, DOI: 10.1053/gast.2001.25516.Peer-Reviewed Original ResearchConceptsProinflammatory cytokinesFluorescein-labeled dextranIL-1Interferon gammaCAMP-dependent fluid secretionCystic fibrosis transmembrane conductance regulatorBile duct epitheliumRat bile duct epitheliaTumor necrosis factorCyclic adenosine monophosphate levelsSecretin receptorAdenosine monophosphate levelsBile duct unitsDuctular cholestasisPortal inflammationCholestatic disordersIL-6Inflammatory cytokinesTNF-alphaBiliary epitheliumNecrosis factorCellular cyclic adenosine monophosphate (cAMP) levelsDuct epitheliumPurinergic agonistsSR expression