Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation
Riva G, Cilibrasi C, Bazzoni R, Cadamuro M, Negroni C, Butta V, Strazzabosco M, Dalprà L, Lavitrano M, Bentivegna A. Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation. Genes 2018, 9: 522. PMID: 30373123, PMCID: PMC6267016, DOI: 10.3390/genes9110522.Peer-Reviewed Original ResearchGSC proliferationMethylation changesBioinformatics analysisGenome-wide dataStem cellsWnt/β-catenin signalingCell-signaling pathwaysWnt/β-catenin signaling activationWnt/β-cateninValproic acidΒ-catenin signalingVPA effectsHistone deacetylase inhibitorsGlioma stem cellsTrypan blue assayReal-time PCRLuciferase reporterN-cadherinSignaling ActivationPleiotropic effectsAnti-cancer effectsΒ-cateninE-cadherinCommon malignant brain tumorGSC invasion