Functional polarity of Na+/H+and Cl−/ HCO 3 − exchangers in a rat cholangiocyte cell line
Spirlì C, Granato A, Zsembery A, Anglani F, Okolicsànyi L, LaRusso N, Crepaldi G, Strazzabosco M. Functional polarity of Na+/H+and Cl−/ HCO 3 − exchangers in a rat cholangiocyte cell line. American Journal Of Physiology 1998, 275: g1236-g1245. PMID: 9843758, DOI: 10.1152/ajpgi.1998.275.6.g1236.Peer-Reviewed Original ResearchConceptsRat cholangiocyte cell lineCholangiocyte cell lineHOE 642Intrahepatic bile duct cellsCell linesNHE isoformsBile duct cellsAcid-base transportersPHi recoveryApical administrationBasolateral amilorideSeparate perfusionFirst functional descriptionAcid loadBasolateral aspectNHE3 gene expressionDuct cellsGene expressionRT-PCRApical amilorideElectrolyte transportAE2 mRNAAmilorideHCO-3Isoforms