1991
Effect of Silibinin on biliary lipid composition experimental and clinical study
Nassuato G, Iemmolo R, Strazzabosco M, Lirussi F, Deana R, Francesconi M, Muraca M, Passera D, Fragasso A, Orlando R, Csomós G, Okolicsányi L. Effect of Silibinin on biliary lipid composition experimental and clinical study. Journal Of Hepatology 1991, 12: 290-295. PMID: 1940257, DOI: 10.1016/0168-8278(91)90829-z.Peer-Reviewed Original ResearchConceptsBiliary lipid compositionBiliary cholesterol concentrationTotal bile salt concentrationBile salt concentrationBile flowBiliary cholesterolCholesterol concentrationsBody weightTotal liver cholesterol contentBile saturation indexSignificant dose-dependent inhibitionEffect of silymarinLiver cholesterol contentEffect of silibininDose-dependent inhibitionCoA reductase activitySilymarin treatmentLiver cholesterolPlacebo administrationCholecystectomized patientsControl ratsClinical studiesLipid compositionSilibinin doseSilibinin
1986
The Effect of Drugs on Bile Flow and Composition
Okolicsanyi L, Lirussi F, Strazzabosco M, Jemmolo R, Orlando R, Nassuato G, Muraca M, Crepaldi G. The Effect of Drugs on Bile Flow and Composition. Drugs 1986, 31: 430-448. PMID: 2872047, DOI: 10.2165/00003495-198631050-00003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBileBile Acids and SaltsCatsChlorpromazineCholagogues and CholereticsCholesterolClofibrateColchicineCricetinaeDehydrocholic AcidDiureticsDogsEnterohepatic CirculationEstrogensGlucagonGuinea PigsHumansInsulinLiverMacaca mulattaPhospholipidsRabbitsRatsRifampinRifamycinsSomatostatinTheophyllineUrsodeoxycholic AcidConceptsBile flowBile acidsBile acid sequestrant cholestyramineBiliary bile acid secretionBiliary cholesterol concentrationBiliary cholesterol saturationBiliary cholesterol secretionBile acid concentrationsBile acid secretionBiliary phospholipid concentrationDrug-induced changesComposition of bileUnconjugated bile acidsEffects of drugsVariety of drugsCholesterol secretionHepatic secretionDrug therapyCholesterol saturationUrsodeoxycholic acidBiliary lipidsAcid secretionCholesterol concentrationsD-thyroxineHepatobiliary route