2009
Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2−/− mice
Halilbasic E, Fiorotto R, Fickert P, Marschall H, Moustafa T, Spirli C, Fuchsbichler A, Gumhold J, Silbert D, Zatloukal K, Langner C, Maitra U, Denk H, Hofmann AF, Strazzabosco M, Trauner M. Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2−/− mice. Hepatology 2009, 49: 1972-1981. PMID: 19475687, PMCID: PMC3569724, DOI: 10.1002/hep.22891.Peer-Reviewed Original ResearchConceptsNorursodeoxycholic acidBile duct unitsUnique physiologicSerum bile acid levelsDuct unitsBile acid levelsCholestatic liver diseaseDramatic therapeutic effectsTherapeutic propertiesRelative resistanceCholehepatic shuntingCholestatic injuryPharmacologic featuresLiver histologyLiver diseaseRole of CFTRBile compositionPharmacologic propertiesCholeretic effectNorUDCATherapeutic effectExpression of MRP4Standard dietSerum biochemistryExperimental cholestasis
2001
Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium
Spirlı̀ C, Nathanson M, Fiorotto R, Duner E, Denson L, Sanz J, Di Virgilio F, Okolicsanyi L, Casagrande F, Strazzabosco M. Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium. Gastroenterology 2001, 121: 156-169. PMID: 11438505, DOI: 10.1053/gast.2001.25516.Peer-Reviewed Original ResearchConceptsProinflammatory cytokinesFluorescein-labeled dextranIL-1Interferon gammaCAMP-dependent fluid secretionCystic fibrosis transmembrane conductance regulatorBile duct epitheliumRat bile duct epitheliaTumor necrosis factorCyclic adenosine monophosphate levelsSecretin receptorAdenosine monophosphate levelsBile duct unitsDuctular cholestasisPortal inflammationCholestatic disordersIL-6Inflammatory cytokinesTNF-alphaBiliary epitheliumNecrosis factorCellular cyclic adenosine monophosphate (cAMP) levelsDuct epitheliumPurinergic agonistsSR expression