1995
Intracellular pH regulation in hep G2 cells: Effects of epidermal growth factor, transforming growth factor‐α, and insulinlike growth factor‐II on Na+/H+ exchange activity
Strazzabosco M, Poci C, Spirlì C, Zsembery A, Granato A, Massimino M, Crepaldi G. Intracellular pH regulation in hep G2 cells: Effects of epidermal growth factor, transforming growth factor‐α, and insulinlike growth factor‐II on Na+/H+ exchange activity. Hepatology 1995, 22: 588-597. PMID: 7635429, DOI: 10.1002/hep.1840220232.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAmilorideAmmonium ChlorideAnimalsCarcinoma, HepatocellularCarrier ProteinsCattleCell DivisionDNAEpidermal Growth FactorFetal BloodFluoresceinsFluorescent DyesHumansHydrogen-Ion ConcentrationInsulin-Like Growth Factor IILiver NeoplasmsSodium-Bicarbonate SymportersSodium-Hydrogen ExchangersTransforming Growth Factor alphaTumor Cells, CulturedConceptsInsulinlike growth factor IIEpidermal growth factorTGF-alphaGrowth factor IIHep G2 cellsGrowth factorFactor IIG2 cellsAdministration of EGFLiver growth factorCl/HCO3 exchangeExtrahepatic tumorsAcid/base homeostasisHepatic tumorsAcid loaderFetal calf serumAcid extrudersHepatoma cell linePresence of FCSAcid loadExchange activityMetabolic activationHCO3- exchangeProliferative stimulusAmilorideIntracellular pH regulation in hep G2 cells: Effects of epidermal growth factor, transforming growth factor-α, and insulinlike growth factor-II on Na+H+ exchange activity
Strazzabosco M, Poci C, Spirlì C, Zsembery A, Granato A, Massimino M, Crepaldi G. Intracellular pH regulation in hep G2 cells: Effects of epidermal growth factor, transforming growth factor-α, and insulinlike growth factor-II on Na+H+ exchange activity. Hepatology 1995, 22: 588-597. DOI: 10.1016/0270-9139(95)90584-7.Peer-Reviewed Original ResearchInsulinlike growth factor IIEpidermal growth factorGrowth factor IIHep G2 cellsGrowth factorFactor IIG2 cellsAdministration of EGFLiver growth factorCl/HCO3 exchangeExtrahepatic tumorsAcid/base homeostasisHepatic tumorsAcid loaderFetal calf serumAcid extrudersHepatoma cell linePresence of FCSAcid loadExchange activityMetabolic activationHCO3- exchangeProliferative stimulusTGFαAmiloride
1991
Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH
Benedetti A, Strazzabosco M, Corasanti J, Haddad P, Graf J, Boyer J. Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH. American Journal Of Physiology 1991, 261: g512-g522. PMID: 1887897, DOI: 10.1152/ajpgi.1991.261.3.g512.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAmmoniaAnimalsBariumBicarbonatesCarrier ProteinsCells, CulturedChloride-Bicarbonate AntiportersChloridesHydrogen-Ion ConcentrationIntracellular FluidKineticsLiverMaleRatsRats, Inbred StrainsConceptsAlkaline loadPH-sensitive dye BCECFMM H2DIDSPHi recoveryRegulation of intracellularRat hepatocyte monolayersAcid extrudersMM DIDSRat hepatocytesElectrophysiological techniquesDye BCECFHCO3- exchangerIsolated rat hepatocytesConstant pHoIntracellularMembrane potentialHepatocyte monolayersHepatocytesAcid loading