2011
Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury
Adhikary S, Li H, Heller J, Skarica M, Zhang M, Ganea D, Tuma R. Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury. Journal Of Neurotrauma 2011, 28: 2417-2427. PMID: 21970496, PMCID: PMC3235339, DOI: 10.1089/neu.2011.1853.Peer-Reviewed Original ResearchConceptsSpinal cord injuryInflammatory responseSpinal cordSelective CB2 agonistAutonomic functionCord injuryMotor functionCB2 agonistsToll-like receptor expressionChemokine/cytokine expressionIL-23p19 expressionCell invasionInflammatory cell invasionSignificant reductionContusion injuryPercentage of animalsCXCL-9Immunoreactive microgliaCXCL-11Cytokine expressionIL-23RReceptor expressionInflammatory reactionInjuryEntire study period
2010
Anti-inflammatory property of the cannabinoid receptor-2-selective agonist in spinal cord injury (35.11)
Adhikary S, Hongbo L, Skarica M, Tuma R, Ganea D. Anti-inflammatory property of the cannabinoid receptor-2-selective agonist in spinal cord injury (35.11). The Journal Of Immunology 2010, 184: 35.11-35.11. DOI: 10.4049/jimmunol.184.supp.35.11.Peer-Reviewed Original ResearchAcute spinal cord injurySpinal cord injuryAgonist treatmentImmune cellsCannabinoid receptor-2 selective agonistCord injurySpinal cordAnimal models of CNS disordersContusion model of spinal cord injuryInfiltration of immune cellsModels of CNS disordersT-cell-activating cytokinesTreat neuropathic painExpression of inflammatory moleculesModel of spinal cord injuryModel of acute spinal cord injuryInflammatory immune cellsToll-like receptorsO-1966Neuropathic painCannabinoid receptorsBladder functionRecovery of motorIL-23Anti-inflammatory properties