2012
Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction
Yan Y, Pushparaj A, Gamaleddin I, Steiner RC, Picciotto MR, Roder J, Le Foll B. Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction. Behavioural Brain Research 2012, 230: 34-39. PMID: 22326373, PMCID: PMC3310267, DOI: 10.1016/j.bbr.2012.01.042.Peer-Reviewed Original ResearchConceptsNose-poke behaviorPrior operant trainingFood restrictionDose-response curveNicotine-seeking behaviorC57BL/6J miceIntermittent footshockFlat dose-response curveNaive C57BL/6J miceInjections of nicotineOperant trainingNicotine self-administration paradigmSelf-administration paradigmCue presentationSelf-administered salineNicotine groupNicotine reinforcementLight cue presentationPriming injectionsFR2 scheduleSecond consecutive dayConsecutive daysMiceDaily sessionsNicotine
2005
Impaired Synaptic Plasticity and Learning in Mice Lacking β-Adducin, an Actin-Regulating Protein
Rabenstein RL, Addy NA, Caldarone BJ, Asaka Y, Gruenbaum LM, Peters LL, Gilligan DM, Fitzsimonds RM, Picciotto MR. Impaired Synaptic Plasticity and Learning in Mice Lacking β-Adducin, an Actin-Regulating Protein. Journal Of Neuroscience 2005, 25: 2138-2145. PMID: 15728854, PMCID: PMC1352335, DOI: 10.1523/jneurosci.3530-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAvoidance LearningCalmodulin-Binding ProteinsConditioning, ClassicalCytoskeletonDendritesElectroshockFearFemaleFreezing Reaction, CatalepticGyrus CinguliHippocampusLearning DisabilitiesMaleMaze LearningMemory DisordersMiceMice, Inbred C57BLMice, KnockoutMice, Neurologic MutantsNerve Tissue ProteinsNeuronal PlasticityNucleus AccumbensRNA, MessengerConceptsBeta-adducinActin regulating proteinsCAMP-dependent mannerSynaptic plasticityActin cytoskeletonΒ-adducinCytoskeletal organizationPlasma membraneAdducinCellular mechanismsActivity-dependent synaptic plasticitySitu hybridizationPostsynaptic densityProteinPlasticitySpine morphologyImportant roleCytoskeletonSynaptic stimulationFamilyImpaired synaptic plasticityLong-term potentiationMiceMRNAHybridization
2003
Conditional Expression in Corticothalamic Efferents Reveals a Developmental Role for Nicotinic Acetylcholine Receptors in Modulation of Passive Avoidance Behavior
King SL, Marks MJ, Grady SR, Caldarone BJ, Koren AO, Mukhin AG, Collins AC, Picciotto MR. Conditional Expression in Corticothalamic Efferents Reveals a Developmental Role for Nicotinic Acetylcholine Receptors in Modulation of Passive Avoidance Behavior. Journal Of Neuroscience 2003, 23: 3837-3843. PMID: 12736354, PMCID: PMC6742204, DOI: 10.1523/jneurosci.23-09-03837.2003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningBehavior, AnimalBinding, CompetitiveCerebral CortexElectroshockGene Expression Regulation, DevelopmentalMiceMice, Inbred C57BLMice, Inbred ICRMice, KnockoutMice, TransgenicNeurons, EfferentNicotineNicotinic AgonistsPresynaptic TerminalsReceptors, NicotinicTetracyclineThalamusTransgenesConceptsPrenatal nicotine exposureNicotinic acetylcholine receptorsPassive avoidanceLines of miceNicotine exposureTransgenic miceAcetylcholine receptorsHigh-affinity nicotinic acetylcholine receptorsTetracycline-regulated transgenic systemHigh-affinity nicotinic receptorsPotential neuroanatomical substratesRubidium efflux assaysHigh-affinity nAChRsEffects of nicotineSpecific neuronal populationsPassive avoidance behaviorAttention deficit hyperactivity disorderWild-type animalsDeficit hyperactivity disorderPresynaptic nAChRsCorticothalamic neuronsSite of actionNicotinic receptorsNeuronal populationsCognitive impairment
2000
Gender Differences in Learned Helplessness Behavior Are Influenced by Genetic Background
Caldarone B, George T, Zachariou V, Picciotto M. Gender Differences in Learned Helplessness Behavior Are Influenced by Genetic Background. Pharmacology Biochemistry And Behavior 2000, 66: 811-817. PMID: 10973520, DOI: 10.1016/s0091-3057(00)00271-9.Peer-Reviewed Original ResearchConceptsEscape latencyInescapable shockHelplessness behaviorGenetic backgroundInescapable shock pretreatmentControl miceMale C57BL/6JMixed genetic backgroundB6 xGender differencesNonshocked controlsB6 femalesMiceB6 malesEscape performanceCommon genetic backgroundKnockout modelsHelplessness modelShock pretreatmentMalesFemalesLatencyPain