2019
Perinatal nicotine exposure impairs learning of a skilled forelimb reaching task in male but not female adult mice
Lee AM, Picciotto MR. Perinatal nicotine exposure impairs learning of a skilled forelimb reaching task in male but not female adult mice. Behavioural Brain Research 2019, 367: 176-180. PMID: 30959127, PMCID: PMC6481625, DOI: 10.1016/j.bbr.2019.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsBehavior, AnimalDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMotor SkillsNeuronal PlasticityNicotineNicotinic AgonistsPregnancyPrenatal Exposure Delayed EffectsSex CharacteristicsConceptsNicotine exposureSingle-pellet reaching taskMotor tasksCortical synaptic plasticityPerinatal nicotine exposureDevelopmental nicotine exposureGross motor functionNicotine-treated animalsNicotine-induced changesFemale adult miceSkilled motor taskGross motor performanceAdverse outcomesMotor cortexFemale miceMale miceMotor functionSkilled forelimbPreclinical studiesControl animalsAdult miceImpaired learningSynaptic plasticityFemale pupsMorphologic changes
2017
Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
Jung Y, Lee AM, McKee SA, Picciotto MR. Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators. Scientific Reports 2017, 7: 4315. PMID: 28659613, PMCID: PMC5489536, DOI: 10.1038/s41598-017-04413-1.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderFemaleHumansMaternal ExposureOdds RatioPopulation SurveillancePregnancyPrenatal Exposure Delayed EffectsPublication BiasSmokingTobacco Smoke PollutionConceptsMale smoking prevalenceMaternal smokingNicotine exposureSmoking prevalenceAdult male smoking prevalenceSignificant associationPostnatal nicotine exposureUtero nicotine exposureAutism spectrum disorderRandom-effects modelWorld Health Organization dataMeta-regression analysisSmoking metricsSmoke exposureSecondhand smokingPooled ORsObservational studySpectrum disorderSmokingBrain developmentControl participantsPrevalenceASD riskExposureAssociation
2013
Mediating Role of Stress Reactivity in the Effects of Prenatal Tobacco Exposure on Childhood Mental Health Outcomes
Park A, O’Malley S, King SL, Picciotto MR. Mediating Role of Stress Reactivity in the Effects of Prenatal Tobacco Exposure on Childhood Mental Health Outcomes. Nicotine & Tobacco Research 2013, 16: 174-185. PMID: 23990474, PMCID: PMC3880234, DOI: 10.1093/ntr/ntt131.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildChild Behavior DisordersChild, PreschoolChi-Square DistributionConfounding Factors, EpidemiologicFemaleHumansLongitudinal StudiesMaleMental DisordersMothersPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsSmokingStress, PsychologicalSurveys and QuestionnairesUnited KingdomYoung AdultConceptsMental health outcomesStressful life eventsPrenatal tobacco exposureAdverse mental health outcomesStress reactivityLife eventsMothers' ratingsChildhood mental health outcomesTobacco exposureChildren's reactivityHealth outcomesMiddle childhoodEmotional problemsAvon Longitudinal StudyDifficulties QuestionnairePreschool ageAge 4Mental healthLongitudinal studyProspective population-based studyLarge prospective population-based studyPsychiatric symptomsEarly childhoodPopulation-based studyRatings
2010
Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence
Heath CJ, Horst NK, Picciotto MR. Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence. Physiology & Behavior 2010, 101: 764-769. PMID: 20826170, PMCID: PMC2975773, DOI: 10.1016/j.physbeh.2010.08.021.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnalysis of VarianceAnimalsBehavior, AnimalFemaleHyperkinesisMaternal BehaviorMiceMotor ActivityNicotinePregnancyPrenatal Exposure Delayed EffectsConceptsNicotine administrationMaternal behaviorNeuropharmacological effectsSignificant between-group differencesDrinking water administrationNicotine-exposed micePostnatal weight gainBetween-group differencesOral nicotine consumptionPersistent behavioral alterationsExposure-induced changesNursing miceTransient hyperactivityDrinking waterNicotine exposureEffects of exposureC57BL/6J miceHuman smokingBehavioral alterationsNicotine consumptionPassive nursingWeight gainMiceAdministrationMaternal careCortico-Thalamic Connectivity is Vulnerable to Nicotine Exposure During Early Postnatal Development through α4/β2/α5 Nicotinic Acetylcholine Receptors
Heath CJ, King SL, Gotti C, Marks MJ, Picciotto MR. Cortico-Thalamic Connectivity is Vulnerable to Nicotine Exposure During Early Postnatal Development through α4/β2/α5 Nicotinic Acetylcholine Receptors. Neuropsychopharmacology 2010, 35: 2324-2338. PMID: 20736992, PMCID: PMC2955839, DOI: 10.1038/npp.2010.130.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAvoidance LearningCerebral CortexFemaleMaleMiceMice, Inbred C57BLMice, TransgenicNeural PathwaysNicotinePregnancyPrenatal Exposure Delayed EffectsRadioligand AssayReceptors, NicotinicThalamusConceptsDevelopmental nicotine exposureNicotine exposureNicotinic acetylcholine receptorsAcetylcholine receptorsΑ5 nicotinic acetylcholine receptorConstituents of smokeEarly post-natal periodPrimary addictive componentΑ5 nAChR subunitTobacco smoke exposureCortico-thalamic connectivityPost-natal periodEarly postnatal developmentPassive avoidance behaviorCorticothalamic neuronsAddictive componentCorticothalamic projectionsSmoke exposureReceptor subtypesNAChR subtypesDevelopmental exposureMouse modelNeurodevelopmental periodAnimal modelsBehavioral alterations
2008
Allelic Variation of Calsyntenin 2 (CLSTN2) Modulates the Impact of Developmental Tobacco Smoke Exposure on Mnemonic Processing in Adolescents
Jacobsen LK, Picciotto MR, Heath CJ, Mencl WE, Gelernter J. Allelic Variation of Calsyntenin 2 (CLSTN2) Modulates the Impact of Developmental Tobacco Smoke Exposure on Mnemonic Processing in Adolescents. Biological Psychiatry 2008, 65: 671-679. PMID: 19058786, PMCID: PMC2864130, DOI: 10.1016/j.biopsych.2008.10.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAdolescent DevelopmentAllelic ImbalanceBrainCalcium-Binding ProteinsFemaleGenotypeHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMemory DisordersPhosphoproteinsPregnancyPrenatal Exposure Delayed EffectsProteinsTemporal LobeTobacco Smoke PollutionConceptsAdolescent exposureCalsyntenin-2Visuospatial memoryMedial temporal lobe functionRecall of wordsRecognition memory taskFunctional magnetic resonance imaging (fMRI) dataTemporal lobe functionEnhanced functional connectivityMemory taskVerbal recallMnemonic processingVerbal recognitionIndividual differencesAdolescent developmentLobe functionKIBRA genotypeDependent measuresMagnetic resonance imaging dataFunctional connectivityParahippocampal gyrusSubsequent deficitsBrain regionsMemoryAdolescents
2007
Prenatal and Adolescent Exposure to Tobacco Smoke Modulates the Development of White Matter Microstructure
Jacobsen LK, Picciotto MR, Heath CJ, Frost SJ, Tsou KA, Dwan RA, Jackowski MP, Constable RT, Mencl WE. Prenatal and Adolescent Exposure to Tobacco Smoke Modulates the Development of White Matter Microstructure. Journal Of Neuroscience 2007, 27: 13491-13498. PMID: 18057207, PMCID: PMC6673092, DOI: 10.1523/jneurosci.2402-07.2007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent DevelopmentFemaleHumansMaleNerve Fibers, MyelinatedNerve NetNicotinePregnancyPrenatal Exposure Delayed EffectsSmokingConceptsAuditory processingAdolescent exposureWhite matter microstructureAuditory attention taskSymptoms of inattentionAuditory processing deficitsNicotine-induced disruptionAuditory attentionAttention taskPrenatal exposureProcessing deficitsAuditory signalsAdolescent smokersAdolescent smokingTobacco smokeFractional anisotropyDiffusion tensor anisotropyMaternal smokingCorticofugal fibersInternal capsuleParent educationDevelopmental disruptionReaction timeInternal capsule fibersAnatomical magnetic resonance imagesPrenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: Role of autoreceptors
Elsworth JD, Morrow BA, Nguyen V, Mitra J, Picciotto MR, Roth RH. Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: Role of autoreceptors. Neuroscience 2007, 147: 419-427. PMID: 17543464, PMCID: PMC2855228, DOI: 10.1016/j.neuroscience.2007.04.036.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyAutoreceptorsClonidineCocaineFemaleGenes, fosImmunohistochemistryInjections, IntravenousLocus CoeruleusMaleNeuronsNorepinephrinePrefrontal CortexPregnancyPrenatal Exposure Delayed EffectsRadioligand AssayRatsRats, Sprague-DawleyStress, PsychologicalTyrosine 3-MonooxygenaseConceptsPrenatal cocaine exposureNorepinephrine neuronsCocaine exposurePrenatal cocaineTyrosine hydroxylase-positive neuronsLocus coeruleus norepinephrine neuronsPrenatal cocaine exposure resultsPrenatal saline controlsRole of autoreceptorsLocus coeruleus noradrenergic systemPrenatal treatment groupsCocaine exposure resultsAlpha2-adrenergic receptorsInjection of cocaineGestational day 10Pharmacology of cocaineDaily i.LC neuronsNorepinephrine turnoverPregnant ratsNeurobehavioral deficitsSaline controlsFos expressionNoradrenergic systemRat model