1997
In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR.
Rubenstein R, Egan M, Zeitlin P. In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR. Journal Of Clinical Investigation 1997, 100: 2457-2465. PMID: 9366560, PMCID: PMC508446, DOI: 10.1172/jci119788.Peer-Reviewed Original ResearchConceptsDelta F508-CFTRIB3-1 cellsCystic fibrosis epithelial cellsFunctional chloride channelChloride channelsHigh molecular mass formsModification of oligosaccharidesCF epithelial cellsEpithelial cellsMolecular mass formsTranscriptional regulatorsPlasma membraneGolgi apparatusEndoplasmic reticulumCystic fibrosis transmembrane conductance regulator (CFTR) mutationsCF phenotypeIB3-1Cell surfaceDelta F508 mutationWhole cellsMass formNasal polyp epitheliumRegulator mutationsCFTRF508 mutation
1992
Modulation of Ion Transport in Cultured Rabbit Tracheal Epithelium by Lipoxygenase Metabolites
Egan M, Wagner M, Zeitlin P, Guggino W. Modulation of Ion Transport in Cultured Rabbit Tracheal Epithelium by Lipoxygenase Metabolites. American Journal Of Respiratory Cell And Molecular Biology 1992, 7: 500-506. PMID: 1419026, DOI: 10.1165/ajrcmb/7.5.500.Peer-Reviewed Original ResearchConceptsNordihydroguaiaretic acidPresence of NDGALipoxygenase pathwayTracheal epithelial cellsLeukotriene releaseUnstimulated culturesEpithelial cellsCultured rabbit tracheal epitheliumMicroM nordihydroguaiaretic acidCultured tracheal epithelial cellsRabbit tracheal epitheliumExogenous LTD4NDGA inhibitionRabbit tracheal epithelial cellsFluid balanceCl(-) secretionLipoxygenase metabolitesAdult rabbitsTracheal epitheliumPrior inhibitionLTD4InhibitionLTC4Tracer flux experimentsCells