Elucidating Compound Mechanism of Action by Network Perturbation Analysis
Woo J, Shimoni Y, Yang W, Subramaniam P, Iyer A, Nicoletti P, Martínez M, López G, Mattioli M, Realubit R, Karan C, Stockwell B, Bansal M, Califano A. Elucidating Compound Mechanism of Action by Network Perturbation Analysis. Cell 2015, 162: 441-451. PMID: 26186195, PMCID: PMC4506491, DOI: 10.1016/j.cell.2015.05.056.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAntineoplastic AgentsEpistasis, GeneticGenome-Wide Association StudyMolecular Targeted TherapyNeoplasmsSmall Molecule LibrariesConceptsGenome-wide identificationRegulatory network analysisBind target proteinsCompound's mechanism of actionNovel proteinsTarget proteinsCompound perturbationGlobal dysregulationSmall molecule compoundsCompound similarityProteinNetwork-based approachRepair activityMolecular interactionsTested compoundsCompoundsMechanism of actionNetwork analysisCompound analysisActivity modulationAnticancer drugsCompound efficacyPerturbation profilesSimilarityEffector