2019
Network-based Biased Tree Ensembles (NetBiTE) for Drug Sensitivity Prediction and Drug Sensitivity Biomarker Identification in Cancer
Oskooei A, Manica M, Mathis R, Martínez M. Network-based Biased Tree Ensembles (NetBiTE) for Drug Sensitivity Prediction and Drug Sensitivity Biomarker Identification in Cancer. Scientific Reports 2019, 9: 15918. PMID: 31685861, PMCID: PMC6828742, DOI: 10.1038/s41598-019-52093-w.Peer-Reviewed Original ResearchConceptsMembrane receptor pathwayDrug sensitivity predictionProtein-protein interaction networkDrug sensitivityGenomics of Drug SensitivityDrug targetsGene expression dataIGFR signaling pathwaysAssignment of high weightsBiomarker identificationExpression dataInteraction networkSensitivity predictionSignaling pathwaySignaling pathway inhibitorsReceptor pathwayTree ensemblesPathway inhibitorPathwayGenomeGenesGDSCNeighborhoods of influenceIdentificationSynthetic datasets
2016
Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage–Induced Senescence Program in Gastric Cancer
Francica P, Nisa L, Aebersold D, Langer R, Bladt F, Blaukat A, Stroka D, Martínez M, Zimmer Y, Medová M. Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage–Induced Senescence Program in Gastric Cancer. Clinical Cancer Research 2016, 22: 5322-5336. PMID: 27185371, DOI: 10.1158/1078-0432.ccr-15-2987.Peer-Reviewed Original ResearchConceptsDNA damage-induced senescenceMET inhibitionMET targetingGastric tumorsNegative regulator of senescenceHuman gastric cancer cell linesGastric cancer cell linesInfliction of DNA damageAberrant MET expressionEctopic expression of FoxM1Tumor tissue microarraysCopy number alterationsRegulation of senescenceMET receptor tyrosine kinaseDepletion of FOXM1Receptor tyrosine kinasesGastric tumor cellsExpression of FoxM1Cancer cell linesCancer Genome AtlasDownregulation of FoxM1Deregulated signalingDownstream effectorsNegative regulatorTumor radiosensitivity