2019
A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer
Wagner J, Rapsomaniki M, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, Rees M, Ramaswamy A, Muenst S, Soysal S, Jacobs A, Windhager J, Silina K, van den Broek M, Dedes K, Martínez M, Weber W, Bodenmiller B. A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer. Cell 2019, 177: 1330-1345.e18. PMID: 30982598, PMCID: PMC6526772, DOI: 10.1016/j.cell.2019.03.005.Peer-Reviewed Original ResearchConceptsBreast cancerBreast cancer ecosystemsTumor-associated macrophagesResponse to therapyHuman breast tumorsTumor cell compositionHuman breast cancerNon-tumor tissue samplesPrecision medicine approachT cellsBreast tumorsImmune cellsPoor prognosisAntibody panelTumor cellsTumor ecosystemHeterogeneous diseaseClinical dataDisease progressionTumorSingle-cell atlasMass cytometryPhenotypic abnormalitiesMedicine approachImmune ecosystem
2016
Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage–Induced Senescence Program in Gastric Cancer
Francica P, Nisa L, Aebersold D, Langer R, Bladt F, Blaukat A, Stroka D, Martínez M, Zimmer Y, Medová M. Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage–Induced Senescence Program in Gastric Cancer. Clinical Cancer Research 2016, 22: 5322-5336. PMID: 27185371, DOI: 10.1158/1078-0432.ccr-15-2987.Peer-Reviewed Original ResearchConceptsDNA damage-induced senescenceMET inhibitionMET targetingGastric tumorsNegative regulator of senescenceHuman gastric cancer cell linesGastric cancer cell linesInfliction of DNA damageAberrant MET expressionEctopic expression of FoxM1Tumor tissue microarraysCopy number alterationsRegulation of senescenceMET receptor tyrosine kinaseDepletion of FOXM1Receptor tyrosine kinasesGastric tumor cellsExpression of FoxM1Cancer cell linesCancer Genome AtlasDownregulation of FoxM1Deregulated signalingDownstream effectorsNegative regulatorTumor radiosensitivity