2016
Dexmedetomidine for hyperactive delirium: worth further study
Knauert MP, Pisani MA. Dexmedetomidine for hyperactive delirium: worth further study. Journal Of Thoracic Disease 2016, 8: e999-e1002. PMID: 27747045, PMCID: PMC5059358, DOI: 10.21037/jtd.2016.08.14.Commentaries, Editorials and LettersRisk factorsIntensive care unit patientsLength of ICUHistory of hypertensionCare unit patientsManagement of painPre-existing dementiaSeverity of illnessClinical practice guidelinesCritical care issuesHigher healthcare costsHistory of alcoholismLong-term cognitionPoor ICU outcomesCritical care medicineICU incidenceICU medicationsIntravenous haloperidolHospital stayHyperactive deliriumICU deliriumAdult patientsUnit patientsMechanical ventilationICU outcomes
2015
Association of COPD With Risk for Pulmonary Infections Requiring Hospitalization in HIV-Infected Veterans
Attia EF, McGinnis KA, Feemster LC, Akgün KM, Butt AA, Graber CJ, Fine MJ, Goetz MB, Rodriguez-Barradas MC, Pisani MA, Tindle HA, Brown ST, Hoo G, Rimland D, Gibert CL, Huang L, Freiberg MS, Hough CL, Crothers K. Association of COPD With Risk for Pulmonary Infections Requiring Hospitalization in HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 70: 280-288. PMID: 26181820, PMCID: PMC4607625, DOI: 10.1097/qai.0000000000000751.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCommunity-acquired pneumoniaPneumocystis jirovecii pneumoniaIndependent risk factorIncidence rate ratiosPulmonary infectionRisk factorsAssociation of COPDBurden of COPDVeterans Aging Cohort Study Virtual CohortRisk of CAPMultivariable Poisson regression modelsBaseline comorbid conditionsDifferent pulmonary infectionsInfections Requiring HospitalizationCD4 cell countHIV viral loadChronic lung diseaseObstructive pulmonary diseaseMultivariable Poisson regressionUnadjusted incidence rateNinth Revision codesPoisson regression modelsJirovecii pneumoniaPulmonary tuberculosis
2013
The Safety of Thoracentesis in Patients with Uncorrected Bleeding Risk
Puchalski JT, Argento AC, Murphy TE, Araujo KL, Pisani MA. The Safety of Thoracentesis in Patients with Uncorrected Bleeding Risk. Annals Of The American Thoracic Society 2013, 10: 336-341. PMID: 23952852, PMCID: PMC3960907, DOI: 10.1513/annalsats.201210-088oc.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsBlood Coagulation DisordersClopidogrelCohort StudiesDrainageFemaleHepatic InsufficiencyHumansInternational Normalized RatioMaleMiddle AgedPlatelet Aggregation InhibitorsPleural EffusionPostoperative HemorrhageProspective StudiesRenal Insufficiency, ChronicRisk FactorsThrombocytopeniaTiclopidineWarfarinConceptsBleeding riskHematocrit levelsProspective observational cohort studySafety of thoracentesisWithholding of medicationsObservational cohort studyPotential bleeding riskElevated INRCohort studyRenal diseaseCommon etiologyPleural effusionRisk factorsObservational studyPatientsThoracentesisMedicationsHemothoraxTransfusionSignificant differencesRiskDiseasePhysiological factorsPhysiological parametersSafetyRisk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans
Akgün KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Risk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 62: 52-59. PMID: 23111572, PMCID: PMC4182723, DOI: 10.1097/qai.0b013e318278f3fa.Peer-Reviewed Original ResearchConceptsVACS Index scoreMedical intensive care unit admissionIntensive care unit admissionVeterans Aging Cohort StudyCare unit admissionMICU admissionIndex scoreRisk factorsHazardous alcohol useVACS IndexUnit admissionCurrent smokingChronic obstructive pulmonary diseaseAlcohol useNon-AIDS diseasesVA administrative databasesMultivariable Cox regressionSurvival of HIVObstructive pulmonary diseaseAging Cohort StudyElectronic medical recordsAntiretroviral therapyCause mortalityPrior AIDSPrior cancer
2012
ICU delirium
Jones SF, Pisani MA. ICU delirium. Current Opinion In Critical Care 2012, 18: 146-151. PMID: 22322260, DOI: 10.1097/mcc.0b013e32835132b9.Peer-Reviewed Original ResearchConceptsICU deliriumRisk factorsLong-term neurocognitive impairmentDelirium-related outcomesPreferred pharmacologic treatmentSignificant adverse outcomesUse of sedativesUse of protocolsPharmacologic treatmentAtypical antipsychoticsVentilator managementAdverse outcomesUnderdiagnosed problemDeliriumNeurocognitive impairmentSusceptible individualsAvailable evidenceRecent evidenceOutcomesLong-term impactTreatmentLimited studiesRobust evidenceNegative outcomesManagementEpidemiology and Management of Common Pulmonary Diseases in Older Persons
Akgün KM, Crothers K, Pisani M. Epidemiology and Management of Common Pulmonary Diseases in Older Persons. The Journals Of Gerontology Series A 2012, 67A: 276-291. PMID: 22337938, PMCID: PMC3297767, DOI: 10.1093/gerona/glr251.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma of LungAgedAged, 80 and overAnti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic AgentsAsthmaFemaleHumansIdiopathic Pulmonary FibrosisIncidenceLung DiseasesLung NeoplasmsMalePneumoniaPrevalencePulmonary Disease, Chronic ObstructiveRisk FactorsTreatment OutcomeConceptsOlder patientsPulmonary diseaseCommon pulmonary diseasesQuality of lifePulmonary symptomsChronic obstructive pulmonary diseaseCommon clinical presentationObstructive pulmonary diseaseIdiopathic pulmonary fibrosisCommon pulmonary disordersMedical comorbiditiesClinical presentationPulmonary fibrosisLung cancerMultiple etiologiesPulmonary disordersRisk factorsPrevalence increasesDisease prevalence increasesPatientsOlder personsDiseaseMortalityDyspneaComorbidities
2011
Pulmonary Embolism in Older Patients
Mathur A, Sauler M, Pisani M. Pulmonary Embolism in Older Patients. Respiratory Medicine 2011, 133-153. DOI: 10.1007/978-1-60761-727-3_7.ChaptersVenous thromboembolic diseaseDeep vein thrombosisPulmonary embolismThromboembolic diseaseComplications of treatmentMiddle-aged subjectsHospital deathOlder patientsVein thrombosisSignificant morbidityGeriatric populationRisk factorsMedical conditionsEmbolismPatientsDiseaseDiagnosisDeathAgeTreatmentMorbidityThrombosisComplicationsPathophysiologyMajor studies
2009
Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population*
Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population*. Critical Care Medicine 2009, 37: 177-183. PMID: 19050611, PMCID: PMC2700732, DOI: 10.1097/ccm.0b013e318192fcf9.Peer-Reviewed Original ResearchConceptsModifiable risk factorsICU deliriumDelirium durationOpioid useRisk factorsFirst episodeMedical intensive care unit patientsIntensive care unit deliriumMedical intensive care unitIntensive care unit patientsUrban university teaching hospitalConfusion Assessment MethodProspective cohort studyCare unit patientsSeverity of illnessIntensive care unitUniversity Teaching HospitalMain outcome measuresUse of benzodiazepinesChart review methodMultivariable regression modelsImpact of benzodiazepinesCohort studyMedian durationUnit patients
2008
Analytic Reviews: Considerations in Caring for the Critically Ill Older Patient
Pisani MA. Analytic Reviews: Considerations in Caring for the Critically Ill Older Patient. Journal Of Intensive Care Medicine 2008, 24: 83-95. PMID: 19114416, DOI: 10.1177/0885066608329942.Peer-Reviewed Original ResearchConceptsOlder patientsPhysiologic changesOlder intensive care unit patientsIntensive care unit admissionIntensive care unit patientsIll Older PatientsImportant physiologic changesOlder ICU patientsCare unit admissionCare unit patientsDevelopment of sepsisSeverity of illnessUnit admissionCritical illnessUnit patientsICU patientsPoor outcomeAdverse outcomesRisk factorsCritical careOutcome studiesChronologic agePatientsAge 65Sepsis
2007
Characteristics Associated With Delirium in Older Patients in a Medical Intensive Care Unit
Pisani MA, Murphy TE, Van Ness PH, Araujo KL, Inouye SK. Characteristics Associated With Delirium in Older Patients in a Medical Intensive Care Unit. JAMA Internal Medicine 2007, 167: 1629-1634. PMID: 17698685, DOI: 10.1001/archinte.167.15.1629.Peer-Reviewed Original ResearchConceptsAdmission risk factorsMedical record reviewIntensive care unitICU admissionRisk factorsOlder patientsRecord reviewCare unitMedical intensive care unitUrban university teaching hospitalOlder ICU patientsReceipt of benzodiazepinesConfusion Assessment MethodPatients 60 yearsProspective cohort studyLower arterial pHUniversity Teaching HospitalMain outcome measuresMultivariate logistic regressionDelirium durationICU deliriumCohort studyCreatinine levelsICU patientsArterial pH
2003
Underrecognition of Preexisting Cognitive Impairment by Physicians in Older ICU Patients
Pisani MA, Redlich C, McNicoll L, Ely EW, Inouye SK. Underrecognition of Preexisting Cognitive Impairment by Physicians in Older ICU Patients. CHEST Journal 2003, 124: 2267-2274. PMID: 14665510, DOI: 10.1378/chest.124.6.2267.Peer-Reviewed Original ResearchConceptsOlder ICU patientsCognitive impairmentICU patientsPhysician recognitionUrban university teaching hospitalCross-sectional comparative studyBlessed Dementia Rating ScalePreexisting Cognitive ImpairmentIndependent risk factorMedical record abstractionUniversity Teaching HospitalCognitive impairment increasesDementia Rating ScaleMajority of casesMedical ICUPatient factorsRecord abstractionICU physiciansIntensive carePhysician interviewsRisk factorsTeaching hospitalSerious illnessICUInformant QuestionnaireCognitive impairment in the intensive care unit
Pisani MA, McNicoll L, Inouye SK. Cognitive impairment in the intensive care unit. Clinics In Chest Medicine 2003, 24: 727-737. PMID: 14710700, DOI: 10.1016/s0272-5231(03)00092-3.Peer-Reviewed Original ResearchConceptsPre-existing cognitive impairmentCognitive impairmentICU stayICU settingRisk factorsPost-ICU stayRate of deliriumDevelopment of deliriumIntensive care unitPsychoactive medication usePersistence of deliriumDelirium preventionDelirium ratesMedical ICUOlder patientsFrequent complicationMedication useCare unitHigh prevalenceDeliriumICUOlder personsStayImpairmentPatients