2000
Significant interaction between clozapine and cocaine in cocaine addicts
Farren C, Hameedi F, Rosen M, Woods S, Jatlow P, Kosten T. Significant interaction between clozapine and cocaine in cocaine addicts. Drug And Alcohol Dependence 2000, 59: 153-163. PMID: 10891628, DOI: 10.1016/s0376-8716(99)00114-3.Peer-Reviewed Original ResearchConceptsSerum cocaine levelsCocaine levelsClozapine pretreatmentIntranasal cocaineBaseline pulse rateNear-syncopal eventsSignificant pressor effectSystolic blood pressureDoses of clozapinePossible therapeutic roleDose-dependent mannerMale cocainePressor effectSyncopal episodesBlood pressureOral challengeSingle doseBlood levelsTherapeutic roleClozapineCocaine addictionPulse rateCocaineDoseDependent manner
1999
Interactions of Cocaine with Nimodipine: A Brief Report
Kosten T, Woods S, Rosen M, Pearsall H. Interactions of Cocaine with Nimodipine: A Brief Report. American Journal On Addictions 1999, 8: 77-81. PMID: 10189518, DOI: 10.1080/105504999306117.Peer-Reviewed Original Research
1996
Acute cocaine effects on absolute cerebral blood flow
Wallace E, Wisniewski G, Zubal G, vanDyck C, Pfau S, Smith E, Rosen M, Sullivan M, Woods S, Kosten T. Acute cocaine effects on absolute cerebral blood flow. Psychopharmacology 1996, 128: 17-20. PMID: 8944401, DOI: 10.1007/s002130050104.Peer-Reviewed Original ResearchConceptsRelative cerebral blood flowCerebral blood flowBlood flowWhole-brain blood flowAbsolute cerebral blood flowBrain blood flowBlood flow changesAcute cocaine effectsRelative blood flow changesCocaine effectsMean decreaseCocaine useCocaine usersSignificant decreaseFlow changesMicrosphere modelVasoconstrictionStrokeGender differences in response to intranasal cocaine administration to humans
Kosten T, Kosten T, McDougle C, Hameedi F, McCance E, Rosen M, Oliveto A, Price L. Gender differences in response to intranasal cocaine administration to humans. Biological Psychiatry 1996, 39: 147-148. PMID: 8717615, DOI: 10.1016/0006-3223(95)00386-x.Peer-Reviewed Original Research
1995
Behavioral, physiological, and pharmacological interaction of cocaine and disulfiram in humans
Hameedi F, Rosen M, McCance-Katz E, McMahon T, Price L, Jatlow P, Woods S, Kosten T. Behavioral, physiological, and pharmacological interaction of cocaine and disulfiram in humans. Biological Psychiatry 1995, 37: 560-563. PMID: 7619981, DOI: 10.1016/0006-3223(94)00361-6.Peer-Reviewed Original ResearchDiscriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans.
Oliveto A, Rosen M, Woods S, Kosten T. Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans. Journal Of Pharmacology And Experimental Therapeutics 1995, 272: 231-41. PMID: 7815337.Peer-Reviewed Original ResearchConceptsDose-effect curve determinationsPlacebo-appropriate respondingDose-related increaseCocaine-appropriate respondingCocaine-abusing volunteersDose-effect curvesBlood pressureCardiovascular effectsOral doseIntranasal routeIntranasal cocaineCocaine dosesHeart rateTraining doseBenzodiazepine triazolamPlaceboCocaine HClBehavioral effectsCardiovascular measuresCocaineTriazolamSimilar increaseDiscriminative stimulusDoseSubjects
1993
Effects of Acute Buprenorphine on Responses to Intranasal Cocaine: A Pilot Study
Rosen M, Pearsall H, McDougle C, Price L, Woods S, Kosten T. Effects of Acute Buprenorphine on Responses to Intranasal Cocaine: A Pilot Study. The American Journal Of Drug And Alcohol Abuse 1993, 19: 451-464. PMID: 8273766, DOI: 10.3109/00952999309001634.Peer-Reviewed Original Research
1992
Use of cocaine to prevent opiate withdrawal
Rosen M, Wallace E, Sullivan M, Stine S, Kosten T. Use of cocaine to prevent opiate withdrawal. American Journal Of Psychiatry 1992, 149: 1609b-1609. PMID: 1415835, DOI: 10.1176/ajp.149.11.1609b.Peer-Reviewed Original ResearchA pilot trial of gepirone vs. placebo in the treatment of cocaine dependency.
Jenkins S, Warfield N, Blaine J, Cornish J, Ling W, Rosen M, Urschel H, Wesson D, Ziedonis D. A pilot trial of gepirone vs. placebo in the treatment of cocaine dependency. Psychopharmacology Bulletin 1992, 28: 21-6. PMID: 1609038.Peer-Reviewed Original ResearchConceptsGlobal Assessment ScaleAddiction Severity IndexClinical Global Impressions-Global Improvement ScaleCocaine useGlobal Improvement ScaleHamilton Rating ScaleHamilton Anxiety ScaleEvaluable patientsAdverse eventsMean dosePilot trialOpiate abuseImprovement ScaleInterim analysisTreatment groupsAssessment ScaleCocaine dependenceFavorable trendOlder ageCCS scoresStudy outcomesRating ScaleGepironeTreatment measuresSeverity IndexCocaine-Associated Panic Attacks in Methadone-Maintained Patients
Rosen M, Kosten T. Cocaine-Associated Panic Attacks in Methadone-Maintained Patients. The American Journal Of Drug And Alcohol Abuse 1992, 18: 57-62. PMID: 1314016, DOI: 10.3109/00952999209001611.Peer-Reviewed Original ResearchBuprenorphine for cocaine and opiate dependence.
Kosten T, Rosen M, Schottenfeld R, Ziedonis D. Buprenorphine for cocaine and opiate dependence. Psychopharmacology Bulletin 1992, 28: 15-9. PMID: 1609037.Peer-Reviewed Original ResearchConceptsCocaine abuseMixed opioid agonist/antagonistOpioid agonist/antagonistPreliminary human studiesAgonists/antagonistsBuprenorphine treatmentOpioid dependenceMethadone maintenanceClinical trialsConcurrent dependencePreclinical studiesCocaine effectsBuprenorphineHuman studiesPlace preferenceChallenge studiesCocaineMethadoneTreatmentTrialsAbuseDose dependenceOpioidsAntagonistDaily
1991
Buprenorphine: Beyond Methadone?
Rosen M, Kosten T. Buprenorphine: Beyond Methadone? Psychiatric Services 1991, 42: 347-349. PMID: 2050347, DOI: 10.1176/ps.42.4.347.Peer-Reviewed Original ResearchConceptsConnecticut Mental Health CenterHuman immunodeficiency virusPromising new treatmentMental health centersSubstance abuse treatmentDepartment of PsychiatryAbuse of cocaineIntravenous heroinImmunodeficiency virusHealth centersYale University SchoolNew treatmentsAbuse treatmentGuest authorsDrug addictsDr. RosenUniversity SchoolRisk-taking behaviorTreatmentMethadoneResearch UnitHeroinCocaine