2015
RNA ligation in neurons by RtcB inhibits axon regeneration
Kosmaczewski SG, Han SM, Han B, Meyer B, Baig HS, Athar W, Lin-Moore AT, Koelle MR, Hammarlund M. RNA ligation in neurons by RtcB inhibits axon regeneration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 8451-8456. PMID: 26100902, PMCID: PMC4500288, DOI: 10.1073/pnas.1502948112.Peer-Reviewed Original Research
2009
Axon Regeneration Requires a Conserved MAP Kinase Pathway
Hammarlund M, Nix P, Hauth L, Jorgensen EM, Bastiani M. Axon Regeneration Requires a Conserved MAP Kinase Pathway. Science 2009, 323: 802-806. PMID: 19164707, PMCID: PMC2729122, DOI: 10.1126/science.1165527.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAxonsAxotomyCaenorhabditis elegansCaenorhabditis elegans ProteinsGamma-Aminobutyric AcidGrowth ConesMAP Kinase Kinase 4MAP Kinase Kinase KinasesMAP Kinase Signaling SystemMitogen-Activated Protein KinasesModels, BiologicalMotor NeuronsMutationNerve RegenerationRNA InterferenceConceptsCell-intrinsic regeneration pathwaysKinase pathwayCaenorhabditis elegans motor neuronsMitogen-activated protein kinase pathwayMAP kinase cascadeMAP kinase pathwayProtein kinase pathwayGrowth cone migrationKinase cascadeRegeneration pathwayCone migrationLater stepsLack of activationDevelopment of therapiesMature neuronsPathwayAplastic statesMost neuronsRegenerationMotor neuronsAxon injuryAxon regenerationNeuron functionActivationNeurons
2000
Mutations in β-Spectrin Disrupt Axon Outgrowth and Sarcomere Structure
Hammarlund M, Davis W, Jorgensen E. Mutations in β-Spectrin Disrupt Axon Outgrowth and Sarcomere Structure. Journal Of Cell Biology 2000, 149: 931-942. PMID: 10811832, PMCID: PMC2174563, DOI: 10.1083/jcb.149.4.931.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAxonsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell MembraneCell PolarityDNA PrimersDNA, ComplementaryEpithelial CellsGenes, HelminthGenes, ReporterGreen Fluorescent ProteinsIntestinesIntracellular MembranesLuminescent ProteinsMolecular Sequence DataMutationSarcomeresSequence Homology, Amino AcidSpectrinSynaptic VesiclesConceptsCell polarityBeta spectrinMembrane skeletonCell membraneCaenorhabditis elegans homologueMost animal cellsSpecific membrane proteinsMembrane integrityAxon outgrowthNull mutantsMembrane proteinsAnimal cellsAbnormal axon outgrowthPlasma membraneSarcomere structureProteinDense bodiesMembraneOutgrowthMajor componentMyofilament latticeMutantsHomologuesGenesPolarity