2018
Loss of c-KIT expression in breast cancer correlates with malignant transformation of breast epithelium and is mediated by KIT gene promoter DNA hypermethylation
Janostiak R, Vyas M, Cicek AF, Wajapeyee N, Harigopal M. Loss of c-KIT expression in breast cancer correlates with malignant transformation of breast epithelium and is mediated by KIT gene promoter DNA hypermethylation. Experimental And Molecular Pathology 2018, 105: 41-49. PMID: 29852185, DOI: 10.1016/j.yexmp.2018.05.011.Peer-Reviewed Original ResearchConceptsC-kit expressionNormal breast tissueC-kitMalignant transformationReceptor tyrosine kinasesBreast tissueBreast cancer correlatesKIT proto-oncogene receptor tyrosine kinaseBreast cancer cell linesC-kit protein expressionBreast tumor developmentProto-oncogene receptor tyrosine kinaseBreast tumor samplesCancer cell linesNormal breast epithelial tissuesTyrosine kinaseBreast epithelial tissueCancer correlatesBreast malignancyC-kit mRNABreast epitheliumBreast tumorsTransmembrane receptor tyrosine kinaseCopy number alterationsTumor samples
2014
Methylation of Twelve CpGs in Human Papillomavirus Type 16 (HPV16) as an Informative Biomarker for the Triage of Women Positive for HPV16 Infection
Brandsma JL, Harigopal M, Kiviat NB, Sun Y, Deng Y, Zelterman D, Lizardi PM, Shabanova VS, Levi A, Yaping T, Hu X, Feng Q. Methylation of Twelve CpGs in Human Papillomavirus Type 16 (HPV16) as an Informative Biomarker for the Triage of Women Positive for HPV16 Infection. Cancer Prevention Research 2014, 7: 526-533. PMID: 24556390, DOI: 10.1158/1940-6207.capr-13-0354.Peer-Reviewed Original ResearchConceptsCervical intraepithelial neoplasiaCytology samplesCutoff scoreColposcopy of womenCervical cancer preventionManagement of womenDetection of CIN3Cervical cytology samplesHuman papillomavirus type 16Human papillomavirus type 16 DNAMethylation biomarkersPapillomavirus type 16Histologic severityIntraepithelial neoplasiaCervical cancerHPV16 infectionCancer preventionDNA bisulfite sequencingType 16Prognostic potentialAccurate biomarkersProspective biomarkersScreening testInformative biomarkersBiomarkers
2009
Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy
Brandsma JL, Sun Y, Lizardi PM, Tuck DP, Zelterman D, Haines GK, Martel M, Harigopal M, Schofield K, Neapolitano M. Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. Virology 2009, 389: 100-107. PMID: 19443004, PMCID: PMC2918277, DOI: 10.1016/j.virol.2009.03.029.Peer-Reviewed Original ResearchConceptsRoutine cervical cancer screeningCervical cellsCervical cancer screeningHigh-grade lesionsLow-grade lesionsHPV16-positive samplesCervical progressionNegative cytologyCervical lesionsCancer screeningCervical samplesPathologic diagnosisCervical carcinogenesisClinical significanceHuman papillomavirus gene expressionLow-level methylationLarger studyE6 geneL1 regionLesionsAbnormal patternsClinical samplesPattern ADistinct methylation patternsHigh-level methylation