High Expression of Mammalian Target of Rapamycin Is Associated with Better Outcome for Patients with Early Stage Lung Adenocarcinoma
Anagnostou VK, Bepler G, Syrigos KN, Tanoue L, Gettinger S, Homer RJ, Boffa D, Detterbeck F, Rimm DL. High Expression of Mammalian Target of Rapamycin Is Associated with Better Outcome for Patients with Early Stage Lung Adenocarcinoma. Clinical Cancer Research 2009, 15: 4157-4164. PMID: 19509151, DOI: 10.1158/1078-0432.ccr-09-0099.Peer-Reviewed Original ResearchConceptsLung cancer patientsMTOR expressionCancer patientsMammalian targetEarly-stage lung adenocarcinomaHigh mTOR expressionIndependent lower riskMedian overall survivalStage IA patientsProtein expressionSubgroup of patientsLung adenocarcinoma patientsStage lung adenocarcinomaMTOR protein expressionRole of mTOROverall survivalPathologic characteristicsPatient survivalValidation cohortAdenocarcinoma groupAdenocarcinoma patientsPrognostic stratificationLung cancerTraining cohortFavorable outcomeAssociation of expression of bcl-2 with outcome in non-small cell lung cancer
Anagnostou V, Lowery F, Syrigos K, Frangia K, Zolota V, Panagopoulos N, Dougenis D, Tanoue L, Detterbeck F, Homer R, Rimm D. Association of expression of bcl-2 with outcome in non-small cell lung cancer. Journal Of Clinical Oncology 2009, 27: e22039-e22039. DOI: 10.1200/jco.2009.27.15_suppl.e22039.Peer-Reviewed Original ResearchLung cancer patientsSquamous cell carcinomaBcl-2 expressionCancer patientsCell carcinomaBcl-2Non-small cell lung cancerYale-New Haven HospitalIndependent lower riskPatras University HospitalMedian overall survivalProtein expressionPotential prognostic parametersSubgroup of patientsCell lung cancerHigh Bcl-2 expressionNew Haven HospitalBcl-2 protein expressionAssociation of expressionBcl-2 protein levelsOverall survivalPatient survivalValidation cohortPathological characteristicsPrognostic parameters